ChemicalBook > CAS DataBase List > (R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam

(R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam

Product Name
(R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam
CAS No.
116195-15-4
Chemical Name
(R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam
Synonyms
(R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam;2-Propen-1-one, 2-methyl-1-[(3aS,6R,7aR)-tetrahydro-8,8-dimethyl-2,2-dioxido-3H-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-
CBNumber
CB03161933
Molecular Formula
C14H21NO3S
Formula Weight
283.39
MOL File
116195-15-4.mol
More
Less

(R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam Property

Melting point:
145 °C
Boiling point:
397.5±25.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-14.95±0.40(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

AK Scientific
Product number
4356CS
Product name
(R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam
Packaging
250mg
Price
$80
Updated
2021/12/16
AK Scientific
Product number
4356CS
Product name
(R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam
Packaging
5g
Price
$212
Updated
2021/12/16
Chemenu
Product number
CM247929
Product name
1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)-2-methylprop-2-en-1-one
Purity
97%
Packaging
5g
Price
$449
Updated
2021/12/16
Ambeed
Product number
A544363
Product name
(R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam
Purity
97%
Packaging
5g
Price
$90
Updated
2021/12/16
Chemenu
Product number
CM247929
Product name
1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)-2-methylprop-2-en-1-one
Purity
97%
Packaging
1g
Price
$163
Updated
2021/12/16
More
Less

(R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam Chemical Properties,Usage,Production

Synthesis

94594-90-8

920-46-7

116195-15-4

Example 2: Synthesis of (R)-5-methyl-4,5-dihydro-pyrazole-1,5-dicarboxylic acid 1-[(4-chloro-phenyl)-amido]5-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amido} Step 1. Synthesis of (3aS,6R,7aR)-1-methacryloyl-8,8-dimethylhexahydro-3a,6-methylene-2,1-benzisothiazole-2,2-dioxide (1S)-(-)-2,10-camphorsulfonate To a solution of (1S)-(-)-2,10-camphorsulfonamide (1.160 g, 5.388 mmol) in toluene (10 ml) was added sodium hydride (60% oil, 0.323 g, 8.08 mmol). After stirring for 1.5 h, methacryloyl chloride (1.126 g, 10.78 mmol) was added directly to the reaction mixture. The mixture was stirred overnight at room temperature, followed by evaporation of the solvent. The residue was extracted into ethyl acetate, washed with 1N HCl, dried with MgSO4, evaporated in vacuum and purified by chromatography (0-20% EtOAc in hexane solution) to afford the target compound (1.240 g, 81%). 1H NMR (400MHz, DMSO-D6) δ ppm: 0.90 (s, 3H), 1.08 (s, 3H), 1.23 (m, 1H), 1.42 (m, 1H), 1.78 (m, 5H), 1.81 (m, 3H), 3.26 (s, 4H), 3.56 (d, J = 14.04Hz, 1H), 3.77 (d , J = 14.04Hz, 1H), 3.91 (m, 1H), 5.48 (s, 1H), 5.60 (s, 1H).

References

[1] Journal of Organic Chemistry, 2008, vol. 73, # 8, p. 3218 - 3227
[2] Patent: WO2008/65503, 2008, A1. Location in patent: Page/Page column 36
[3] Tetrahedron Asymmetry, 1991, vol. 2, # 12, p. 1359 - 1370

(R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam Suppliers

China 24 India 1 Global 25
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Beijing Taiya Jie Technology Development Co., Ltd.
Tel
021-33690831-8001 13552411790
Fax
021-33690831
Email
postmaster@tyjchem.cn
Country
China
ProdList
1542
Advantage
55
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5674
Advantage
50
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Henan Anky Chemical Technology Co., Ltd.
Tel
17836913271
Fax
0374-8348899
Email
3224305243@qq.com
Country
China
ProdList
2944
Advantage
58
Aikon International Limited
Tel
025-66061636 18013972705
Fax
(3)02557626880
Email
qqyang@aikonchem.com
Country
China
ProdList
15814
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25356
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
Advantage
58
More
Less

View Lastest Price from (R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam manufacturers

Career Henan Chemical Co
Product
((R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam 116195-15-4
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10t
Release date
2019-12-20

116195-15-4, (R)-(-)-(2-Methylacryloyl)-2,10-camphorsultamRelated Search:

(1R)-(-)-(10-Camphorsulfonyl)oxaziridine (2R)-Bornane-10,2-sultam (1S)-(-)-CAMPHORSULFONYLIMINE N-Acryloyl-(2S)-bornane-10,2-sultam N-PROPIONYL-(2R)-BORNANE- 10,2-SULTAM Oppolzer's caMphor sultaM N-PROPIONYL-(2S)-BORNANE- 10,2-SULTAM (S)-(+)-(2-Methylacryloyl)-2,10-camphorsultam (N-Acetyl)-(2S)-bornane-10,2-sultaM (1S)-(+)-(Camphorylsulfonyl)oxaziridine (2S)-Bornane-10,2-sultam (N-CROTONYL)-(2R)-BORNANE-10,2-SULTAM (S)-(+)-(2-BUTENOYL)-2 10-CAMPHORSULTAM (+)-10-CAMPHORSULFONIMINE N-ACETYL-(2S)-BORNANE 10,2-SULTAM

  • (R)-(-)-(2-Methylacryloyl)-2,10-camphorsultam
  • 2-Propen-1-one, 2-methyl-1-[(3aS,6R,7aR)-tetrahydro-8,8-dimethyl-2,2-dioxido-3H-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-
  • 116195-15-4