7,8-DIHYDRO-L-BIOPTERIN

Product Name: 7,8-DIHYDRO-L-BIOPTERIN
CAS No.: 6779-87-9
Chemical Name: 7,8-DIHYDRO-L-BIOPTERIN
Synonyms: BH2;DIHYDROBIOPTERIN;7,8-dihydrobiopterin;Biopterin Impurity 1;Biopterin impurity 6;7,8-DIHYDRO-L-BIOPTERIN;Sapropterin Impurity 18;L-erythro-Dihydrobiopterin;L-erythro-7,8-Dihydrobiopterin;2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-1H-pteridin-4-one
CBNumber: CB0320957
Molecular Formula: C9H13N5O3
Formula Weight: 239.23
MOL File: 6779-87-9.mol

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7,8-DIHYDRO-L-BIOPTERIN Property

Melting point:: >300°C dec.
Boiling point:: 470.8±55.0 °C(Predicted)
Density: 1.88
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: Aqueous Acid (Slightly, Sonicated), Aqueous Base (Slightly), DMSO (Slightly)
pka: 10.47±0.20(Predicted)
form: Solid
color: Pale Yellow to Brown
BRN: 536551
Stability:: Hygroscopic
InChIKey: FEMXZDUTFRTWPE-AWFVSMACSA-N
CAS DataBase Reference: 6779-87-9

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Safety

WGK Germany: 3
F: 3-10

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 37272
Product name: 7,8-Dihydro-L-biopterin
Purity: ≥94% (HPLC)
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Sigma-Aldrich

Product number: 37272
Product name: 7,8-Dihydro-L-biopterin
Purity: ≥94% (HPLC)
Packaging: 50mg
Price: $470
Updated: 2024/03/01

Cayman Chemical

Product number: 81882
Product name: 7,8-dihydro-L-Biopterin
Purity: ≥97%
Packaging: 5mg
Price: $45
Updated: 2024/03/01

Cayman Chemical

Product number: 81882
Product name: 7,8-dihydro-L-Biopterin
Purity: ≥97%
Packaging: 10mg
Price: $72
Updated: 2024/03/01

Cayman Chemical

Product number: 81882
Product name: 7,8-dihydro-L-Biopterin
Packaging: 50mg
Price: $330
Updated: 2024/03/01

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7,8-DIHYDRO-L-BIOPTERIN Chemical Properties,Usage,Production

Description

BH₂ is a precursor of BH₄ synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a K_i of 14.4 μM.

Chemical Properties

Yellow Powder

Uses

An oxidation producct of tetrahydrobiopterin, a naturally occurring cofactor of the aromatic amino acid hydroxylase and is involved in the synthesis of tyrosine and the neurotransmitters dopamine and serotonin. It is a noncompetitive inhibitor of G

Uses

BH2 is a precursor of BH4 synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM.

Uses

The reduced form of Biopterin. An oxidation product of tetrahydrobiopterin, a naturally occurring cofactor of the aromatic amino acid hydroxylase and is involved in the synthesis of tyrosine and the neurotransmitters dopamine and serotonin. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM.

Definition

ChEBI: L-erythro-7,8-dihydrobiopterin is a 7,8-dihydrobiopterin in which the 1,2-dihydroxypropyl group has (1R,2S)-configuration; naturally occurring form. It is an enantiomer of a D-erythro-7,8-dihydrobiopterin.

References

[1] shen r, alam a, zhang y. inhibition of gtp cyclohydrolase i by pterins[j]. biochimica et biophysica acta (bba)-general subjects, 1988, 965(1): 9-15.
[2] sugiyama t, levy b d, michel t. tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells[j]. journal of biological chemistry, 2009, 284(19): 12691-12700.

7,8-DIHYDRO-L-BIOPTERIN Preparation Products And Raw materials

Raw materials

Preparation Products

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7,8-DIHYDRO-L-BIOPTERIN Suppliers

Canada 1 China 71 Germany 1 India 3 Switzerland 2 United Kingdom 4 United States 14 Global 96

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6779-87-9, 7,8-DIHYDRO-L-BIOPTERINRelated Search:

2,4-Diamino-6-hydroxypyrimidine 7,8-DIHYDRO-L-BIOPTERIN 4-Pyrimidinol Isocytosine 4-Hydroxy-6-aminopyrimidine 4,5-Diamino-6-hydroxypyrimidine

7,8-dihydrobiopterin

7,8-DIHYDRO-L-BIOPTERIN

2-AMINO-6-(1R,2S-DIHYDROXYPROPYL)-7,8-DIHYDRO-4(1H)-PTERIDINONE

1-(2-Amino-4-hydroxy-7,8-dihydropteridin-7-yl)propane-1,2-diol

BH2

DIHYDROBIOPTERIN

2-Amino-6-(1,2-dihydroxy-propyl)-7,8-dihydro-3H-pteridin-4-one

2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-7,8-dihydro-4(3H)-pteridinone

2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-1H-pteridin-4-one

4(1H)-pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-

L-erythro-7,8-Dihydrobiopterin

L-erythro-Dihydrobiopterin

2-aMino-6-((1S,2R)-1,2-dihydroxypropyl)-7,8-dihydropteridin-4(3H)-one

4(3H)-Pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-7,8-dihydro-

2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-7,8-dihydropteridin-4(1H)-one

Sapropterin Impurity 18

inhibit,7,8 Dihydro L biopterin,Inhibitor,7,8DihydroLbiopterin,Endogenous Metabolite

Biopterin Impurity 1

Biopterin impurity 6

6779-87-9

C9H13N5O3

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