Description
ChemicalBook > CAS DataBase List > (R)-(+)-PROPRANOLOL

(R)-(+)-PROPRANOLOL

Description
Product Name
(R)-(+)-PROPRANOLOL
CAS No.
13071-11-9
Chemical Name
(R)-(+)-PROPRANOLOL
Synonyms
AY 20694;ICI 47319;R-PROPANOLOL;d-Anapriline;R-PROPRANOLOL;(+)-Anapriline;(R)-(+)-PROPRANOLOL;R-(+)-PROPANOLOL HCL;expropranololhydrochloride;d-Propranolol hydrochloride
CBNumber
CB0327608
Molecular Formula
C16H21NO2.ClH
Formula Weight
295.81
MOL File
13071-11-9.mol
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(R)-(+)-PROPRANOLOL Property

Melting point:
196-198 °C(lit.)
storage temp. 
Store below +30°C.
solubility 
ethanol: 10 mg/mL
form 
Solid
color 
White to Off-White
Water Solubility 
Soluble to 100 mM in water
BRN 
5780490
CAS DataBase Reference
13071-11-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
2922 19 00
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P0689
Product name
(R)-(+)-Propranolol hydrochloride
Purity
≥98% (TLC)
Packaging
100mg
Price
$106
Updated
2024/03/01
Sigma-Aldrich
Product number
P0689
Product name
(R)-(+)-Propranolol hydrochloride
Purity
≥98% (TLC)
Packaging
500mg
Price
$424
Updated
2024/03/01
Tocris
Product number
0835
Product name
(R)-(+)-Propranolol hydrochloride
Packaging
100
Price
$87
Updated
2021/12/16
TRC
Product number
P831790
Product name
(R)-(+)-Propranolol hydrochloride
Packaging
5g
Price
$1190
Updated
2021/12/16
ChemScene
Product number
CS-0021023
Product name
(R)-(+)-Propranolol hydrochloride
Purity
≥97.0%
Packaging
100mg
Price
$80
Updated
2021/12/16
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(R)-(+)-PROPRANOLOL Chemical Properties,Usage,Production

Description

(R)-Propranolol hydrochloride is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.

Physical properties

(R)-Propranolol's solubility:ethanol: 10 mg/mLDMSO: <14.5 mg/mLH2O: 50 mg/mL (With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.)

Uses

less active enantiomer

Uses

The R-enantiomer of Propranolol (P831800). β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).

Biochem/physiol Actions

Less active enantiomer of propranolol.

Mechanism of action

Pronolol hydrochloride is a non-selective beta-receptor blocker that blocks beta receptors in the myocardium and has antagonistic effects on beta1 and beta2 receptors. Slow down the heart rate, inhibit cardiac contractility and conduction, reduce circulating blood volume, and reduce myocardial oxygen consumption.

storage

Store at RT

Purification Methods

The hydrochloride is recrystallised from n-PrOH or Me2CO. It is soluble in H2O and EtOH but is insoluble in Et2O, *C6H6 or EtOAc. The racemate has m 163-164o, and the free base recrystallises from cyclohexane with m 96o. [Howe & Shanks Nature 210 1336 1966.] The S-isomer (below) is the physiologically active isomer.

(R)-(+)-PROPRANOLOL Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(+)-PROPRANOLOL Suppliers

Canada 2 China 68 Germany 4 India 4 South Korea 1 Switzerland 1 Ukraine 1 United Kingdom 6 United States 14 Global 101
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
Merck Schuchardt OHG
Tel
--
Fax
--
Email
schuchardt-vertrieb@merck.de
Country
Germany
ProdList
5827
Advantage
74
ENDOTHERM GmbH
Tel
--
Fax
--
Email
dr.kattner@endotherm.de
Country
Germany
ProdList
78
Advantage
42
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View Lastest Price from (R)-(+)-PROPRANOLOL manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
(R)-(+)-PROPRANOLOL 13071-11-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
(R)-(+)-PROPRANOLOL 13071-11-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1lg; 2kg; 5kg; 10kg; 100kg
Release date
2019-08-31

13071-11-9, (R)-(+)-PROPRANOLOLRelated Search:

(R)-4-Hydroxy Propranolol Hydrochloride,(S)-4-Hydroxy Propranolol Hydrochloride (R)-(+)-PROPRANOLOL PROPRANOLOL H+D409CL USP,DL-Propranolol hydrochloride, (±)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride Propranolol Hydrochloride for pharmaceutical raw materials L-(-)-Propranolol hydrochloride,l-Propranolol chlorhydrate,l-Propranolol hydrochloride Propanolol 4-Hydroxy Propranolol b-D-Glucuronide,4-Hydroxy Propranolol -D-Glucuronide rac Propranolol -D-Glucuronide Sodium Salt,propranolol glucuronide,rac Propranolol b-D-Glucuronide Sodium Salt (S)-4-Hydroxy Propranolol (+/-)-4Hydroxy Propranolol-d7 Sulfate 5-Hydroxy Propranolol-d5 rac 7-Hydroxy Propranolol O-isovaleryl propranolol (2S)-Propranolol,l-Propranolol Propranolol hydrochloride for performance test (R)-4-Hydroxy Propranolol 4-HYDROXY PROPRANOLOL-D5 GLUCURONIDE rac 4-Hydroxy Propranolol-d7 -D-Glucuronide

  • R-PROPANOLOL
  • R-(+)-PROPANOLOL HCL
  • 2R-(+)-Propanolol hydrochloride≥ 95% (GCMS)
  • (R)-(+)-Propanolol hydrochloride for synthesis
  • 2R-(+)-PROPANOLOL HYDROCHLORIDE
  • 2-Propanol, 1-(1-methylethyl)amino-3-(1-naphthalenyloxy)-, hydrochloride, (2R)-
  • (+)-Anapriline
  • 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)-, hydrochloride, (+)- (8CI)
  • 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (2R)- (9CI)
  • 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (R)-
  • AY 20694
  • d-Anapriline
  • d-Propranolol hydrochloride
  • ICI 47319
  • R-(+)-1-Isopropylamino-3-(1-naphthoxy)-2-propanol hydrochloride
  • (R)-(+)-PROPANOLOL HYDROCHLORIDE
  • (R)-(+)-PROPRANOLOL
  • R-PROPRANOLOL
  • (R)-(+)-PROPRANOLOL HYDROCHLORIDE
  • (R)-PROPRANOLOL HYDROCHLORIDE
  • (R)-(+)-1-[(1-METHYLETHYL)AMINO]-3-(1-NAPHTHALENYLOXY)-2-PROPANOL HYDROCHLORIDE
  • (R)-(+)-1-(ISOPROPYLAMINO)-3-(1-NAPHTHYLOXY)-2-PROPANOL HYDROCHLORIDE
  • (R)-1-ISOPROPYLAMINO-3-(1-NAPHTHYLOXY)-2-PROPANOL HYDROCHLORIDE
  • Dexpropranolol hydrochloride
  • (R)-(+)-Propranolol hydrochloride,(R)-1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride
  • (R)-[2-hydroxy-3-(naphthyloxy)propyl]isopropylammonium chloride
  • (R)-(+)-PROPANOLOL HYDROCHLORIDE 99+%
  • (R)-1-(isopropylaMino)-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride
  • (2R)-1-(1-naphthalenyloxy)-3-(propan-2-ylamino)-2-propanol hydrochloride
  • (R)-(+)-PROPANOLOL HYDROCHLORIDE FOR SYN
  • expropranololhydrochloride
  • Inhibitor,enantiomer,Beta Receptor,(R)-Propranolol,Adrenergic Receptor,β-adrenoceptor,cardiac arrhythmias,(R)Propranolol hydrochloride,(R) Propranolol hydrochloride,inhibit
  • Flumiclorac-pentyl Impurity 11
  • 13071-11-9
  • C16H21NOSHCl
  • C10H7OCH2CHOHCH2NHCHCH32HCl
  • Organic Building Blocks
  • Amino Alcohols
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals