Saikosaponin D

Product Name: Saikosaponin D
CAS No.: 20874-52-6
Chemical Name: Saikosaponin D
Synonyms: Saikoside d;saikosaponin;saikosaponins;SAIKOSAPONIN D;SAILKOSAPONIN D;Saikosaponian D;SAILKOSAPONINS D;Saikosaponin D(P);Saikosaponin D-RM;SAIKOSAPONIN D(RG)
CBNumber: CB0329374
Molecular Formula: C42H68O13
Formula Weight: 780.99
MOL File: 20874-52-6.mol

More

Less

Saikosaponin D Property

Melting point:: 212～218℃
Boiling point:: 893.7±65.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Hygroscopic, Refrigerator, Under inert atmosphere
solubility: Methanol (Slightly), Pyridine (Slightly)
form: Solid
pka: 12.83±0.70(Predicted)
color: White to Off-White
Stability:: Hygroscopic
LogP: 3.756 (est)
CAS DataBase Reference: 20874-52-6

More

Less

Safety

Safety Statements: 24/25
RTECS: VN3099000
HS Code: 29389090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More

Less

N-Bromosuccinimide Price

TRC

Product number: S083915
Product name: SaikosaponinD
Packaging: 2.5mg
Price: $50
Updated: 2021/12/16

TRC

Product number: S083915
Product name: SaikosaponinD
Packaging: 10mg
Price: $80
Updated: 2021/12/16

Usbiological

Product number: 297731
Product name: Saikosaponin D
Packaging: 5mg
Price: $319
Updated: 2021/12/16

Usbiological

Product number: 300910
Product name: Saikosaponin D
Packaging: 20mg
Price: $390
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb594260
Product name: Saikosaponin D
Packaging: 100mg
Price: $418.2
Updated: 2021/12/16

More

Less

Saikosaponin D Chemical Properties,Usage,Production

Description

Saikosaponin D is a triterpene saponin found in Bupleurum that exhibits antioxidative, immunomodulatory, anti-fibrotic, anti-angiogenic, anticancer, and chemopreventive activities. Saikosaponin D increases activity of superoxide dismutase, catalase, and glutathione peroxidase and decreases activity of malondialdehyde in cellular models of oxidative damage. In other in vitro models, saikosaponin D increases secretion of IL-12, maturation of dendritic cells, and proliferation of lymphocytes. Saikosaponin D inhibits SERCA, increasing intracellular Ca2+ and inducing autophagy. In vivo, this compound decreases severity of fibrosis. In embryos, saikosaponin D decreases microvessel formation. Additionally, this compound decreases tumor formation in DEN-treated animal models and suppresses expression of CEBP-β and COX-2. Saikosaponin D also induces apoptosis and activation of caspases 3 and 7 in hepatocellular carcinoma cells. Saikosaponin D is a Glucocorticoid receptor agonist. It is a COX-2 and iNOS inhibitor.

Uses

Saikosaponin d (SSd) is an important active component of Bupleurum scorzonerifolium Willd., a traditional Chinese medicinal herb. Saikosaponins such as Saikosaponin D are used to help analyse and resolve the activities of herbal medicines such as Sho-saiko-to.

Uses

Saikosaponin D is an inhibitor of proliferation of human prostate cancer cells through arresting the cell cycle.

Biological Activity

Saikosaponin D inhibits cell growth of human cancer cells by inducing apoptosis and blocking cell cycle progression in the G1 phase. Saikosaponin D was found to stimulate corticotropin-releasing factor (CRF) gene expression and CRF release.

Clinical claims and research

We have previously identified a small-molecule, saikosaponin-d (Ssd), that exhibits anti-inflammatory effect via the suppression of NF-κB, NF-AT and AP-1 signaling. We recently showed that Ssd potentiated the anti-cancer potency of TNF-α through NF-κB inhibition. Ssd is one of the major triterpenoid saponins derived from Bupleurum falcatum L. (Umbelliferae), which is commonly prescribed for inflammatory and infectious diseases, and its active component Ssd was reported to have immuno-modulatory, anti-inflammatory, anti-bacterial, anti-viral and anti-cancer activities.

Saikosaponin D Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Saikosaponin D Suppliers

China 236 Germany 2 India 1 Japan 2 Switzerland 1 United Kingdom 8 United States 28 USA 1 Global 279

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

BOC Sciences

Tel: 16314854226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 9713
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Protheragen-ING

Tel: +16313385890
Email: info@protheragen-ing.com
Country: United States
ProdList: 3868
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Wilshire Chemical Company Inc.

Tel: --
Fax: --
Email: WilshrChem@AOL.COM
Country: United States
ProdList: 3498
Advantage: 58

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

FortopChem Technology Limited

Tel: --
Fax: --
Email: sales@fortopchem.com
Country: United States
ProdList: 1099
Advantage: 50

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

Ivy Fine Chemicals

Tel: --
Fax: --
Email: sales@ivychem.com
Country: United States
ProdList: 6493
Advantage: 58

ChemPacific Corporation

Tel: --
Fax: --
Email: sales@chempacific.com
Country: United States
ProdList: 6891
Advantage: 51

BOSCHE SCIENTIFIC, LLC

Tel: --
Fax: --
Email: Sales@BoscheSci.com
Country: United States
ProdList: 6477
Advantage: 55

Sinova Inc.

Tel: --
Fax: --
Email: sales@sinovainc.com
Country: United States
ProdList: 4009
Advantage: 58

QVENTAS INC.

Tel: --
Fax: --
Email: mike@qventas.com
Country: United States
ProdList: 383
Advantage: 47

ChromaDex

Tel: --
Fax: --
Email: sales@chromadex.com
Country: United States
ProdList: 2501
Advantage: 76

AvaChem Scientific LLC

Tel: --
Fax: --
Email: Info@avachem.com
Country: United States
ProdList: 315
Advantage: 30

Beta Pharma, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 6226
Advantage: 60

LKT Laboratories, Inc.

Tel: --
Fax: --
Email: info@lktlabs.com
Country: United States
ProdList: 2164
Advantage: 64

More

Less

View Lastest Price from Saikosaponin D manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Saikosaponin D 20874-52-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 95%; 98% HPLC
Supply Ability: 1000kg
Release date: 2022-10-14

Shaanxi Haibo Biotechnology Co., Ltd

Product: Saikosaponin D 20874-52-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000ton
Release date: 2023-08-21

Shanghai Standard Technology Co., Ltd.

Product: Saikosaponin D 20874-52-6
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-09-29

20874-52-6, Saikosaponin DRelated Search:

Resin epoxy Saponin Ginsenoside Rh2 Saikosaponin B2 Saikosaponin a Saikosaponin C Saikosaponin B1 SAGITTATOSIDE A Sagittatosdie B 2-CYCLOHEXEN-1-OL 2,2,4,4,6,8,8-HEPTAMETHYLNONANE Ginsenosides Escin sodium TETRAHYDRO-3-FURANMETHANOL N-OCTYL-BETA-D-GLUCOPYRANOSIDE cis-9-Tricosene HEXAMETHYLENE OXIDE EPOXY

(3b,4a,16a)-13,28-Epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-beta-D-glucopyranosyl beta-D-galactopyranoside

SAIKOSAPONIN D

Saikosaponin D, 98%, from Bupleurum chinense DC.

saikosaponin

saikosaponins

Saikosaponian D

SAIKOSAPONIN D 98+% BY HPLC

SAILKOSAPONINS D

Saikosaponin d std.

SAILKOSAPONIN D

SAIKOSAPONIN D(RG)

Saikoside d

SAIKOSAPONIN B2(P)

Saikosaponin D 20874-52-6

b-D-Galactopyranoside, (3b,4a,16a)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-b-D-glucopyranosyl-

Bupleurum saikosaponin D

β-D-Galactopyranoside, (3β,4α,16α)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-

(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-3,5-Dihydroxy-2-(((3S,4R,4aR,6aR,6bS,8R,8aS,12aR,12bS,14aR,14bS)-8-hydroxy-4-(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,9,10,11,12,12a,14a,14b-octadecahydro-12b,8a-(epoxymethano)picen-3-yl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Saikosaponin D(P)

Saikosaponin D-RM

20874-52-6

20736-52-6

C48H78O18

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Aromatic Phenols