PSMA-11

PSMA-11 Property

storage temp. 

-20°C, protect from light

solubility 

To be determined:100.0(Max Conc. mg/mL);105.6(Max Conc. mM)

form 

Solid

color 

White to off-white

InChIKey

QJUIUFGOTBRHKP-DPMCXAKDNA-N

SMILES

C(C(O)=O)C[C@@H](C(O)=O)NC(=O)N[C@H](C(O)=O)CCCCNC(=O)CCCCCNC(=O)CCC1=CC=C(O)C(CN(CCN(CC2=CC(CCC(O)=O)=CC=C2O)CC(O)=O)CC(O)=O)=C1 |&1:5,13,r|

Hazard and Precautionary Statements (GHS)

PSMA-11 Chemical Properties,Usage,Production

Description

PSMA-11 is a small molecule ligand that targets prostate-specific membrane antigen (PSMA) and has the ability to inhibit PSMA activity. PSMA-11 can be used to synthesize 68Ga-PSMA-11, a positron emission tomography (PET) tracer that can be used to image advanced prostate cancer.

Uses

The prostate-specific membrane antigen (PSMA) has received increased consideration during the past few years as an excellent target for both imaging and therapy of prostate cancer. ?After many years of outstanding preclin.

References

[1] Demirci E, et al. Normal distribution pattern and physiological variants of 68Ga-PSMA-11 PET/CT imaging. Nucl Med Commun. 2016 Nov;37(11):1169-79.
[2] Eder M, et al. 68Ga-complex lipophilicity and the targeting property of a urea-based PSMA inhibitor for PET imaging[J]. Bioconjugate chemistry, 2012, 23(4): 688-697.
[3] Bois F, et al. [68Ga] Ga-PSMA-11 in prostate cancer: a comprehensive review[J]. American Journal of Nuclear Medicine and Molecular Imaging, 2020, 10(6): 349.
[4] ANDREI GAFITA. qPSMA: Semiautomatic Software for Whole-Body Tumor Burden Assessment in Prostate Cancer Using 68Ga-PSMA11 PET/CT.[J]. Journal of Nuclear Medicine, 2019, 60 9: 1277-1283. DOI:10.2967/jnumed.118.224055.