DICHLORISONE ACETATE

Product Name: DICHLORISONE ACETATE
CAS No.: 79-61-8
Chemical Name: DICHLORISONE ACETATE
Synonyms: Sch 5005;DICHLORISONE ACETATE;dichlorisone 21-acetate;21-Acetyloxy-9,11β-dichloro-17-hydroxypregna-1,4-diene-3,20-dione;1, 4-PREGNADIEN-9α, 11β-DICHLORO-17, 21-DIOL-3, 20-DIONE 21-ACETATE;9α,11β-Dichloro-17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate;1,4-PREGNADIEN-9-ALPHA, 11-BETA-DICHLORO-17,21-DIOL-3,20-DIONE 21-ACETATE;inhibit,Inhibitor,Dichlorisone,Endogenous Metabolite,Dichlorisone Acetate;Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-9,11-dichloro-17-hydroxy-, (11b)-;Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9,11-dichloro-17-hydroxy-, (11β)-
CBNumber: CB0339584
Molecular Formula: C23H28Cl2O5
Formula Weight: 455.37
MOL File: 79-61-8.mol

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DICHLORISONE ACETATE Property

Melting point:: 246-253 °C (decomp)
Boiling point:: 596.2±50.0 °C(Predicted)
alpha: D25 +162° (dioxane)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 4.35 mg/mL (9.55 mM); Water: < 0.1 mg/mL (insoluble)
pka: 11.94±0.70(Predicted)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-7866
Product name: Dichlorisone acetate
Purity: 99.77%
Packaging: 10mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-7866
Product name: Dichlorisone acetate
Purity: 99.77%
Packaging: 50mg
Price: $108
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: SHG0000402
Product name: DICHLORISONE ACETATE
Purity: 95.00%
Packaging: 500MG
Price: $597.4
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: SHG0000402
Product name: DICHLORISONE ACETATE
Purity: 95.00%
Packaging: 1G
Price: $695.39
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: SHG0000402
Product name: DICHLORISONE ACETATE
Purity: 95.00%
Packaging: 5G
Price: $1050.24
Updated: 2021/12/16

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DICHLORISONE ACETATE Chemical Properties,Usage,Production

Originator

Diloderm ,Schering,US,1960

Uses

antipruretic

Definition

ChEBI: Dichlorisone is a corticosteroid hormone.

Manufacturing Process

A solution of 1.0 g of 1,4,9(11)-pregnatriene-17α,21-diol-3,20-dione-21- acetate and 5.0 g of lithium chloride in 40 ml of glacial acetic acid is treated
with 0.410 g of N-chlorosuccinimide, followed by 0.104 g of anhydrous hydrogen chloride dissolved in 2.5 ml of tetrahydrofuran. The reaction mixture is stirred for 2 hours and poured into ice water. The crude product is filtered and washed with water to give 1.12 g of solid material, which is recrystallized from acetone-hexane to give substantially pure 9α,11β-dichloro-1,4- pregnadiene-17α,21-diol-3,20-dione-21-acetate; MP 246°C to 253°C (dec.).

brand name

Diloderm (Schering).

Therapeutic Function

Antipruritic, Antihistaminic, Appetite stimulant

DICHLORISONE ACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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DICHLORISONE ACETATE Suppliers

China 21 Germany 1 India 1 Switzerland 1 United Kingdom 1 United States 8 Global 33

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79-61-8, DICHLORISONE ACETATERelated Search:

2-CHLORO-2,3-DIMETHYL BUTANE 6-Chlorohexanol 6-Chloro-2-hexanone 1-Chlorotetradecane 6-Chlorohex-1-ene 1-CHLORO-1-METHYLCYCLOHEXANE 1,6-Dichlorohexane (R)-5-CHLORO-2-PENTANOL 1,10-Dichlorodecane 1,9-DICHLORONONANE 2,3-DICHLOROBUTANE 9-chloronon-1-ene 1-CHLORO-3,3-DIMETHYLPENTANE 8-Chloro-1-octene 3-CHLORO-2,2,3-TRIMETHYLBUTANE 10-CHLORO-1-DECANOL CIS-6-CHLORO-2-HEXENE 7-CHLORO-1-HEPTENE

9ALPHA,11BETA-DICHLORO-17ALPHA,21-DIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE

1,4-PREGNADIEN-9-ALPHA, 11-BETA-DICHLORO-17,21-DIOL-3,20-DIONE 21-ACETATE

dichlorisone 21-acetate

9α,11β-Dichloro-17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate

21-Acetyloxy-9,11β-dichloro-17-hydroxypregna-1,4-diene-3,20-dione

Sch 5005

[2-[(9R,17R)-9,11-dichloro-17-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate

[2-[(9R,17R)-9,11-dichloro-17-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] ethanoate

acetic acid [2-[(9R,17R)-9,11-dichloro-17-hydroxy-3-keto-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-keto-ethyl] ester

DICHLORISONE ACETATE

Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9,11-dichloro-17-hydroxy-, (11β)-

Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-9,11-dichloro-17-hydroxy-, (11b)-

inhibit,Inhibitor,Dichlorisone,Endogenous Metabolite,Dichlorisone Acetate

1, 4-PREGNADIEN-9α, 11β-DICHLORO-17, 21-DIOL-3, 20-DIONE 21-ACETATE

79-61-8

C23H28Cl2O5

Inhibitors

DILODERM