ChemicalBook > CAS DataBase List > 2-Nitroimidazole

2-Nitroimidazole

Product Name: 2-Nitroimidazole
CAS No.: 527-73-1
Chemical Name: 2-Nitroimidazole
Synonyms: 2-nitro-1h-imidazole;AZOMYCIN;2-Nitroimidazole sulfate;11a;amicin;ro05-9129;AZOMYCINE;2-NITROMIDAZOLE;2-nitro-imidazo;2-Nitroimidaxole
CBNumber: CB0340968
Molecular Formula: C3H3N3O2
Formula Weight: 113.07
MOL File: 527-73-1.mol

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2-Nitroimidazole Property

Melting point:: 287 °C (dec.) (lit.)
Boiling point:: 211.75°C (rough estimate)
Density: 1.5988 (rough estimate)
refractive index: 1.4264 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: NH4OH: soluble50mg/mL, clear, yellow to orange
form: Powder
pka: 8.72±0.10(Predicted)
color: Light yellow to khaki-green
Water Solubility: insoluble
Merck: 14,921
BRN: 116444
InChIKey: YZEUHQHUFTYLPH-UHFFFAOYSA-N
CAS DataBase Reference: 527-73-1(CAS DataBase Reference)
EPA Substance Registry System: 1H-Imidazole, 2-nitro- (527-73-1)

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Safety

Hazard Codes: Xn,T
Risk Statements: 22-36/37/38-23/24/25-20/21/22
Safety Statements: 26-36-45-36/37/39
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: NI7875000
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29332990
Toxicity: LD50 i.v. in mice: 80 mg/kg (Maeda)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 195650
Product name: 2-Nitroimidazole
Purity: 98%
Packaging: 250mg
Price: $53.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 195650
Product name: 2-Nitroimidazole
Purity: 98%
Packaging: 1g
Price: $71.45
Updated: 2025/07/31

TCI Chemical

Product number: N0891
Product name: 2-Nitroimidazole
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $58
Updated: 2025/07/31

TCI Chemical

Product number: N0891
Product name: 2-Nitroimidazole
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $230
Updated: 2025/07/31

Cayman Chemical

Product number: 29395
Product name: Azomycin
Packaging: 500mg
Price: $33
Updated: 2024/03/01

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2-Nitroimidazole Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

2-Nitroimidazole, is used as an antibiotic in pharma industry.

Uses

2-Nitroimidazole is a antibiotic substance produced by an unidentified Streptomyces,it is used to prepare nitroimidazole substituted boronic acids as precursors for imaging hypoxic tissue 1.It is also used to prepare potential site-selective radiosensitizers for estrogen receptor-rich tumors.

Definition

ChEBI: An imidazole that is 1H-imidazole substituted at position 2 by a nitro group.

General Description

2-Nitroimidazole is a natural antibiotic.

Synthesis

42383-61-9

527-73-1

General procedure for the synthesis of 2-nitroimidazole from 2-aminoimidazole sulfate: 2-aminoimidazole sulfate (1.57 g, 6.01 mmol) was dissolved in water (10 mL) and 50% w/v fluoroboric acid (7 mL). The reaction solution was cooled to -20 °C in an acetone/dry ice bath and a solution of sodium nitrite (4.14 g, 59.6 mmol) in water (10 mL) was added slowly and dropwise. The reaction temperature was maintained at -10 °C and stirred for 30 min. Subsequently, the reaction solution was poured into a solution of copper sulfate (20.0 g, 119 mmol) in water (200 mL). Sodium nitrite (4.14 g, 59.6 mmol) was then added and the reaction mixture was stirred for 2 hours at room temperature. After completion of the reaction, the extract was carried out for 6 hours using a continuous extractor with ethyl acetate (200 mL) as the extractant. The organic phases were combined, concentrated under reduced pressure and the residue was recrystallized from ethanol to give the target compound 2-nitroimidazole as yellow needle-like crystals (870 mg, 65% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 17, p. 5102 - 5106

2-Nitroimidazole Preparation Products And Raw materials

Raw materials

Ethanol Sodium sulfate 2-Aminoimidazole Ethyl hydrazine Sodium nitrite Copper(II) sulfate pentahydrate Fluoroboric acid Diethyl ether Ethyl acetate Nitric acid 2-Aminoimidazole hemisulfate PETROLEUM ETHER 2,2-Diethoxyethylamine

Preparation Products

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View Lastest Price from 2-Nitroimidazole manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Nitroimidazole 527-73-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-16

HebeiShuoshengImportandExportco.,Ltd

Product: 2-Nitroimidazole 527-73-1
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-05

Hebei Longbang Technology Co., Ltd

Product: 2-Nitroimidazole 527-73-1
Price: US $6.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20TONS
Release date: 2024-05-27

527-73-1, 2-NitroimidazoleRelated Search:

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2-NitroiMidazole, 98% 250MG

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2-NitroiMidazole SynonyMs 2-nitro-1H-iMidazole, AzoMycin

Imidazole, 2-nitro-

NITRO-1H-IMIDAZOLE

WLN: T5M CNJ BNW

AZOMYCIN

AZOMYCINE

2-NITROIMIDAZOLE

11a

2-nitro-1h-imidazol

2-nitro-1h-imidazole

2-nitro-imidazol

amicin

2-Nitroimidazole, 98%, for synthesis

2-Nitroimidazole&gt

2-Nitroimidazole Basic information

2-nitro-1H-imidazole - [A37862]

527-73-1

527-3-1

N2C3H2NO2

Building Blocks

Heterocyclic Building Blocks

Imidazoles

Heterocycles

Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines

Imidazol&Benzimidazole

Heterocyclic Compounds

Imidaxoles

Building Blocks

C3 to C8

Chemical Synthesis

Heterocyclic Building Blocks

Imidazoles

OLED materials,pharm chemical,electronic

Pharmaceutical intermediates

Inhibitors

527-73-1