2-CYANO-N-METHYL-ACETAMIDE
- Product Name
- 2-CYANO-N-METHYL-ACETAMIDE
- CAS No.
- 6330-25-2
- Chemical Name
- 2-CYANO-N-METHYL-ACETAMIDE
- Synonyms
- Entacapone Impurity 27;Entacapone Impurity 61;Methyl 2-Cyano Acetamide;N-Methyl-2-cyanoacetamide;2-Cyan-N-methyl-acetamide;N1-METHYL-2-CYANOACETAMIDE;N-(Cyanoacetyl)methylamine;2-CYANO-N-METHYL-ACETAMIDE;Acetamide, 2-cyano-N-methyl-;4-bromo-N-propan-2-yl-1-pentanamine
- CBNumber
- CB0348520
- Molecular Formula
- C4H6N2O
- Formula Weight
- 98.1
- MOL File
- 6330-25-2.mol
2-CYANO-N-METHYL-ACETAMIDE Property
- Melting point:
- 82 °C
- Boiling point:
- 335.3±25.0 °C(Predicted)
- Density
- 1.044±0.06 g/cm3(Predicted)
- vapor pressure
- 0.009Pa at 25℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO, Methanol
- form
- Solid
- pka
- 5.44±0.10(Predicted)
- color
- Pale Yellow
- LogP
- -1.96--0.445 at 25℃
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38-22
- Safety Statements
- 22-26-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M3781
- Product name
- 2-Cyano-N-methylacetamide
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $75
- Updated
- 2025/07/31
- Product number
- M3781
- Product name
- 2-Cyano-N-methylacetamide
- Purity
- min. 98.0 %
- Packaging
- 25G
- Price
- $225
- Updated
- 2025/07/31
- Product number
- C981860
- Product name
- 2-Cyano-N-methylacetamide
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- C981860
- Product name
- 2-Cyano-N-methylacetamide
- Packaging
- 5g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- C981860
- Product name
- 2-Cyano-N-methylacetamide
- Packaging
- 25g
- Price
- $425
- Updated
- 2021/12/16
2-CYANO-N-METHYL-ACETAMIDE Chemical Properties,Usage,Production
Uses
2-Cyano-N-methylacetamide is used in the synthesis of pyridone compounds and benzimidazoles, for various pharmaceutical application.
Synthesis
105-56-6
74-89-5
6330-25-2
1. General procedure for the synthesis of 2-cyano-N-methylacetamide: 20 g (176.8 mmol) of ethyl cyanoacetate was added slowly and dropwise at 0 °C to a tetrahydrofuran (THF) solution of 10.9 g (353.6 mmol) of methylamine, which had been cooled to 0 °C. The reaction was completed with stirring. After the dropwise addition was completed, the reaction mixture was kept at 0 °C with continued stirring. Subsequently, the reaction mixture was stirred at room temperature overnight. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by recrystallization with toluene to give 16.8 g of beige solid product in 96% yield with a melting point of 99 °C.
References
[1] Patent: US2011/251194, 2011, A1. Location in patent: Page/Page column 14
[2] Patent: US2011/124643, 2011, A1. Location in patent: Page/Page column 14
[3] Patent: US2013/178472, 2013, A1. Location in patent: Paragraph 0228
[4] Marine Drugs, 2012, vol. 10, # 6, p. 1412 - 1421
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 12, p. 5350 - 5366
2-CYANO-N-METHYL-ACETAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CYANO-N-METHYL-ACETAMIDE manufacturers
- Product
- 2-CYANO-N-METHYL-ACETAMIDE 6330-25-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 2000
- Release date
- 2025-04-27
- Product
- 2-Cyano-N-methylacetamide 6330-25-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09