2-Amino-5-nitro-4-picoline
- Product Name
- 2-Amino-5-nitro-4-picoline
- CAS No.
- 21901-40-6
- Chemical Name
- 2-Amino-5-nitro-4-picoline
- Synonyms
- 2-AMINO-5-NITRO-4-PICOLINE;2-Amino-5-nitro-4-picoline,98%;4-Methyl-5-nitro-2-pyridinamine;4-methyl-5-nitropyridin-2-amine;2-AMiono-4Methyl-5Nitropyridine;2-Amino-4-Mythyl-5-NitroPyridine;2-Amino-5-nitro-4-methylpyridine;4-Methyl-5-nitropyridine-2-amine;2-Pyridinamine,4-methyl-5-nitro-;2-AMINO-4-METHYL-5-NITROPYRIDINE
- CBNumber
- CB0349709
- Molecular Formula
- C6H7N3O2
- Formula Weight
- 153.14
- MOL File
- 21901-40-6.mol
2-Amino-5-nitro-4-picoline Property
- Melting point:
- 223-225 °C (lit.)
- Boiling point:
- 276.04°C (rough estimate)
- Density
- 1.3682 (rough estimate)
- refractive index
- 1.6500 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Soluble in DMSO.
- pka
- 3.44±0.24(Predicted)
- form
- Powder
- color
- Orange to yellow-brown
- BRN
- 137695
- InChI
- InChI=1S/C6H7N3O2/c1-4-2-6(7)8-3-5(4)9(10)11/h2-3H,1H3,(H2,7,8)
- InChIKey
- GRBBNZYMXKTQAI-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C([N+]([O-])=O)C(C)=C1
- CAS DataBase Reference
- 21901-40-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-37/39-36/37/39-22-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 290092
- Product name
- 2-Amino-4-methyl-5-nitropyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $38.2
- Updated
- 2025/07/31
- Product number
- A1638
- Product name
- 2-Amino-4-methyl-5-nitropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- A1638
- Product name
- 2-Amino-4-methyl-5-nitropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $127
- Updated
- 2025/07/31
- Product number
- M325180
- Product name
- 4-Methyl-5-nitro-2-pyridinamine
- Packaging
- 2.5g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- M325180
- Product name
- 4-Methyl-5-nitro-2-pyridinamine
- Packaging
- 10g
- Price
- $250
- Updated
- 2021/12/16
2-Amino-5-nitro-4-picoline Chemical Properties,Usage,Production
Chemical Properties
orange to yellow-brown powder
Uses
2-Amino-4-methyl-5-nitropyridine was used in the preparation of matrix mixture required to study new technical developments for the direct tissue analysis of peptides.
General Description
The crystal structure of 2-amino-4-methyl-5-nitropyridine was elucidated.
Synthesis
695-34-1
21901-40-6
Example 9: Synthesis of 2-(1-aziridinyl)-4-carbamoyl-5-nitropyridine (Compound VI) Reagents and conditions: (i) HNO3/H2SO4; (ii) NaNO2; (iii) POCl3; (iv) Na2Cr2O7; (v) SOCl2/DMF, followed by NH4OH treatment; (vi) aziridine. Synthesis steps for compound 30: 1. cool concentrated sulfuric acid (240 mL) in an ice bath and slowly add raw compound 29 (2-amino-4-methylpyridine, 50 g, 0.462 mol), keeping the temperature at 0°C. 2. slowly add acid mixture prepared from concentrated sulfuric acid (98%, 55 mL) and concentrated nitric acid (72%, 55 mL) in a 1:1 volume ratio. 3. slowly heat to 50°C and react for 24 hours to ensure complete reaction. 4. Pour the reaction solution into 2 L of ice water, adjust the pH to 7 with a strong base, and filter to collect the precipitate. 5. Dry the filter cake to give 54 g of crude product. 6. The by-product 4-methyl-3-nitro-2-aminopyridine was removed by wet distillation and subsequently recrystallized in 95% ethanol to give 33 g of Compound 30 (2-amino-4-methyl-5-nitropyridine) with a melting point of 220-222 °C (Literature value: 220-222 °C). Yield: 46.6%.
References
[1] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 12-13
[2] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0044
[3] Patent: WO2005/97129, 2005, A2. Location in patent: Page/Page column 176
[4] Patent: WO2012/103806, 2012, A1. Location in patent: Page/Page column 43
2-Amino-5-nitro-4-picoline Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-5-nitro-4-picoline Suppliers
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- 03-36680489
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View Lastest Price from 2-Amino-5-nitro-4-picoline manufacturers
- Product
- 2-Amino-5-nitro-4-picoline 21901-40-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
- Product
- 2-Amino-5-nitro-4-picoline 21901-40-6
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 2-Amino-5-nitro-4-picoline 21901-40-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-07