ChemicalBook > CAS DataBase List > (+)-MAGNOFLORINE IODIDE

(+)-MAGNOFLORINE IODIDE

Product Name
(+)-MAGNOFLORINE IODIDE
CAS No.
2141-09-5
Chemical Name
(+)-MAGNOFLORINE IODIDE
Synonyms
escholin;Esholine;escholine;THALICTRIN;Aids002649;Magflorine;THALICTRINE;Aids-002649;MAGNOFLORINE;(+)-Magnoflorine
CBNumber
CB0350572
Molecular Formula
C20H24INO4
Formula Weight
469.31
MOL File
2141-09-5.mol
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(+)-MAGNOFLORINE IODIDE Property

Melting point:
252℃
storage temp. 
2-8°C(protect from light)
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25122
Product name
Magnoflorine
Purity
≥98%
Packaging
5mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
25122
Product name
Magnoflorine
Purity
≥98%
Packaging
10mg
Price
$145
Updated
2024/03/01
Cayman Chemical
Product number
25122
Product name
Magnoflorine
Purity
≥98%
Packaging
25mg
Price
$337
Updated
2024/03/01
Cayman Chemical
Product number
25122
Product name
Magnoflorine
Purity
≥98%
Packaging
50mg
Price
$625
Updated
2024/03/01
Usbiological
Product number
300608
Product name
Magnoflorine Iodide
Packaging
10mg
Price
$448
Updated
2021/12/16
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(+)-MAGNOFLORINE IODIDE Chemical Properties,Usage,Production

Description

A wide variety of species contain this quaternary alkaloid which is widespread among the families, Aquilegia, Magnolia and Michelia. It has been isolated and characterized as the iodide, m.p. 248-9°C (dec.); [0:11>5 + 200.1° (MeOH). The optically inactive base also yields an iodide which crystallizes with 1.5 H20, m.p. 243°C (dec.).

Description

Magnoflorine is an alkaloid and a major constituent of S. acutum that has diverse biological activities. It reduces hemolysis induced by lysophosphatidylcholine (LPC), but not NaCl, in a rat erythrocyte suspension when used at concentrations ranging from 0.01 to 10 μM. Magnoflorine (10 μM) induces intracellular chloride influx in neuroblastoma cells, an effect that is reversed by the GABAA receptor antagonist bicuculline . It reduces TNF-α-induced NF-κB expression as well as production of IL-6 and IL-8 in BEAS-2B cells. In vivo, magnoflorine (20 mg/kg, i.p.) improves short- and long-term memory acquisition in a passive avoidance test in a mouse model of scopolamine-induced memory impairment.

Uses

Magnoflorine-d3 is the labelled analogue of Magnoflorine, an isoquinoline alkaloid from the Coptis japonica and it enhances the myoblast differentiation through activation of the p38 MAP kinase and Akt pathway.

Definition

ChEBI: (S)-magnoflorine is an aporphine alkaloid that is (S)-corytuberine in which the nitrogen has been quaternised by an additional methyl group. It has a role as a plant metabolite. It is an aporphine alkaloid and a quaternary ammonium ion. It is functionally related to a (S)-corytuberine.

References

Nakano., Chem. Pharm. Bull. (Tokyo), 2, 329 (1954) Tomita, Kikkawa.,J. Pharm. Soc., Japan, 77, 195 (1957) Gopinath et aI., J. Sci. Ind. Res., 18B, 444 (1959) Ishii, Harada.,J. Pharm. Soc., Japan, 81,238 (1961) Yang, Lu, Hsiao., ibid, 82,794,816 (1962) Yang, Lu, Hsiao., ibid, 83,216 (1963)

(+)-MAGNOFLORINE IODIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (+)-MAGNOFLORINE IODIDE manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
magnoflorine 2141-09-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-24
Shanghai Standard Technology Co., Ltd.
Product
Magnoflorine 2141-09-5
Price
US $0.00/mg
Min. Order
20mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-03-09
Career Henan Chemical Co
Product
(+)-MAGNOFLORINE IODIDE 2141-09-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-12

2141-09-5, (+)-MAGNOFLORINE IODIDERelated Search:

(-)-Syringaresinol (+)-PINORESINOL EUDESMINE Pinoresinol diMethyl ether galgravin Xanthiazone Homovanillic acid epiberberine Rhamnosylvitexin Nsc150443 magnolin MAGNOFLORINE IODIDE, (+)-(RG) GOSSAMPINI FLOS (+)-MAGNOFLORINE IODIDE (+)-MENISPERINE IODIDE (+)-MAGNOFLORINE IODINE AKOS 221-29 MAGNOFLORINE IODIDE, (+)-(PRIMARY STANDARD)

  • MAGNOFLORINE
  • (+)-MAGNOFLORINE IODIDE
  • MAGNOFLORINE IODIDE, (+)-
  • 1,11-dihydroxy-2,10-dimethoxy-6-methyl-6a-alpha-aporphiniu
  • escholin
  • escholine
  • g)quinolinium,5,6,6a,7-tetrahydro-1,11-dihydroxy-2,10-dimethoxy-4h-dibenzo(d
  • THALICTRIN
  • THALICTRINE
  • (6aS)-1,11-Dihydroxy-2,10-dimethoxy-6,6-dimethyl-5,6,6aα,7-tetrahydro-4H-dibenzo[de,g]quinoline-6-ium
  • Corytuberine Methosalt
  • Esholine
  • (6aS)-5,6,6a,7-Tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium
  • [6aS,(+)]-5,6,6a,7-Tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium
  • 5,6,6A(S),7-Tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-4H-dibenzo[de,G]quinolinium chloride
  • Aids002649
  • Aids-002649
  • Aporphine alkaloid
  • Magflorine
  • alpha-Magnoflorine
  • (+)-Magnoflorine
  • (6aS)-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-6-ium-1,11-diol
  • (S)-1,11-Dihydroxy-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium
  • (+)-MAGNOFLORINE IODIDE
  • 2141-09-5
  • 2041-09-5
  • C33H45NO11I
  • C20H24NO4X
  • C16H24NO4
  • C20H24INO4
  • Alkaloids