ChemicalBook > CAS DataBase List > (+)-MAGNOFLORINE IODIDE

(+)-MAGNOFLORINE IODIDE

Product Name: (+)-MAGNOFLORINE IODIDE
CAS No.: 2141-09-5
Chemical Name: (+)-MAGNOFLORINE IODIDE
Synonyms: escholin;Esholine;escholine;THALICTRIN;Aids002649;Magflorine;THALICTRINE;Aids-002649;MAGNOFLORINE;(+)-Magnoflorine
CBNumber: CB0350572
Molecular Formula: C20H24INO4
Formula Weight: 469.31
MOL File: 2141-09-5.mol

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(+)-MAGNOFLORINE IODIDE Property

Melting point:: 252℃
storage temp.: 2-8°C(protect from light)
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00377
Product name: Magnoflorine
Purity: ≥98% (HPLC)
Packaging: 10 mg
Price: $180
Updated: 2025/07/31

Cayman Chemical

Product number: 25122
Product name: Magnoflorine
Purity: ≥98%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 25122
Product name: Magnoflorine
Purity: ≥98%
Packaging: 10mg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 25122
Product name: Magnoflorine
Purity: ≥98%
Packaging: 25mg
Price: $337
Updated: 2024/03/01

Cayman Chemical

Product number: 25122
Product name: Magnoflorine
Purity: ≥98%
Packaging: 50mg
Price: $625
Updated: 2024/03/01

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(+)-MAGNOFLORINE IODIDE Chemical Properties,Usage,Production

Description

A wide variety of species contain this quaternary alkaloid which is widespread among the families, Aquilegia, Magnolia and Michelia. It has been isolated and characterized as the iodide, m.p. 248-9°C (dec.); [0:11>5 + 200.1° (MeOH). The optically inactive base also yields an iodide which crystallizes with 1.5 H20, m.p. 243°C (dec.).

Description

Magnoflorine is an alkaloid and a major constituent of S. acutum that has diverse biological activities. It reduces hemolysis induced by lysophosphatidylcholine (LPC), but not NaCl, in a rat erythrocyte suspension when used at concentrations ranging from 0.01 to 10 μM. Magnoflorine (10 μM) induces intracellular chloride influx in neuroblastoma cells, an effect that is reversed by the GABA_A receptor antagonist bicuculline . It reduces TNF-α-induced NF-κB expression as well as production of IL-6 and IL-8 in BEAS-2B cells. In vivo, magnoflorine (20 mg/kg, i.p.) improves short- and long-term memory acquisition in a passive avoidance test in a mouse model of scopolamine-induced memory impairment.

Chemical Properties

Off-white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from magnolia, thrush, phellodendron, coptis root, celandine and magnolia.

Uses

Magnoflorine-d3 is the labelled analogue of Magnoflorine, an isoquinoline alkaloid from the Coptis japonica and it enhances the myoblast differentiation through activation of the p38 MAP kinase and Akt pathway.

Definition

ChEBI: (S)-magnoflorine is an aporphine alkaloid that is (S)-corytuberine in which the nitrogen has been quaternised by an additional methyl group. It has a role as a plant metabolite. It is an aporphine alkaloid and a quaternary ammonium ion. It is functionally related to a (S)-corytuberine.

References

Nakano., Chem. Pharm. Bull. (Tokyo), 2, 329 (1954) Tomita, Kikkawa.,J. Pharm. Soc., Japan, 77, 195 (1957) Gopinath et aI., J. Sci. Ind. Res., 18B, 444 (1959) Ishii, Harada.,J. Pharm. Soc., Japan, 81,238 (1961) Yang, Lu, Hsiao., ibid, 82,794,816 (1962) Yang, Lu, Hsiao., ibid, 83,216 (1963)

(+)-MAGNOFLORINE IODIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (+)-MAGNOFLORINE IODIDE manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: magnoflorine 2141-09-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-24

Shanghai Standard Technology Co., Ltd.

Product: Magnoflorine 2141-09-5
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-09

Career Henan Chemical Co

Product: (+)-MAGNOFLORINE IODIDE 2141-09-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 25kg
Release date: 2019-07-12

2141-09-5, (+)-MAGNOFLORINE IODIDERelated Search:

(-)-Syringaresinol (+)-PINORESINOL EUDESMINE Pinoresinol diMethyl ether galgravin Xanthiazone Homovanillic acid epiberberine Rhamnosylvitexin Nsc150443 magnolin MAGNOFLORINE IODIDE, (+)-(RG) GOSSAMPINI FLOS (+)-MAGNOFLORINE IODIDE (+)-MENISPERINE IODIDE (+)-MAGNOFLORINE IODINE AKOS 221-29 MAGNOFLORINE IODIDE, (+)-(PRIMARY STANDARD)

MAGNOFLORINE

(+)-MAGNOFLORINE IODIDE

MAGNOFLORINE IODIDE, (+)-

1,11-dihydroxy-2,10-dimethoxy-6-methyl-6a-alpha-aporphiniu

escholin

escholine

g)quinolinium,5,6,6a,7-tetrahydro-1,11-dihydroxy-2,10-dimethoxy-4h-dibenzo(d

THALICTRIN

THALICTRINE

(6aS)-1,11-Dihydroxy-2,10-dimethoxy-6,6-dimethyl-5,6,6aα,7-tetrahydro-4H-dibenzo[de,g]quinoline-6-ium

Corytuberine Methosalt

Esholine

(6aS)-5,6,6a,7-Tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium

[6aS,(+)]-5,6,6a,7-Tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium

5,6,6A(S),7-Tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-4H-dibenzo[de,G]quinolinium chloride

Aids002649

Aids-002649

Aporphine alkaloid

Magflorine

alpha-Magnoflorine

(+)-Magnoflorine

(6aS)-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-6-ium-1,11-diol

(S)-1,11-Dihydroxy-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium

(+)-Magnoflorine, 10 mM in DMSO

(+)-MAGNOFLORINE IODIDE

2141-09-5

2041-09-5

C33H45NO11I

C20H24NO4X

C16H24NO4

C20H24INO4

Alkaloids