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(4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE

Product Name
(4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE
CAS No.
110859-47-7
Chemical Name
(4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE
Synonyms
BUTTPARK 85\12-11;Mosapride Impurity 22;2-Aminomethyl-4-benzylmorpholine;4-Benzyl-2-(aMinoMethyl)Morpholine;4-(Benzyl)-2-morpholinemethanamine;(4-BENZYLMORPHOLIN-2-YL)METHYLAMINE;(4-Benzyl-2-Morpholinyl)MethanaMine;(4-BENZYLMORPHOLIN-2-YL) METHANAMINE;1-(4-Benzylmorpholin-2-yl)methanamine;(4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE
CBNumber
CB0351791
Molecular Formula
C12H18N2O
Formula Weight
206.28
MOL File
110859-47-7.mol
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(4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE Property

Boiling point:
120-122°C 0,5mm
Density 
1.076
Flash point:
143℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
solid
pka
9.37±0.29(Predicted)
Appearance
Colorless to light yellow Viscous Liquid
optical activity
0.15°(C=1 g/100ml MEOH)
CAS DataBase Reference
110859-47-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
34
Safety Statements 
26-36/37/39
RIDADR 
2735
Hazard Note 
Irritant
HS Code 
2921199990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B130525
Product name
(4-Benzylmorpholin-2-yl)methanamine
Packaging
1g
Price
$275
Updated
2021/12/16
AK Scientific
Product number
X8960
Product name
(4-Benzylmorpholin-2-yl)methanamine
Packaging
250mg
Price
$117
Updated
2021/12/16
Apolloscientific
Product number
OR23186
Product name
(4-Benzylmorpholin-2-yl)methylamine
Purity
95+%
Packaging
500mg
Price
$149
Updated
2021/12/16
SynQuest Laboratories
Product number
4H30-1-06
Product name
(4-Benzylmorpholin-2-yl)methanamine
Purity
95%
Packaging
500mg
Price
$176
Updated
2021/12/16
AK Scientific
Product number
X8960
Product name
(4-Benzylmorpholin-2-yl)methanamine
Packaging
1g
Price
$191
Updated
2021/12/16
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(4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE Chemical Properties,Usage,Production

Synthesis

110859-48-8

110859-47-7

General procedure for the synthesis of (4-benzyl-2-morpholinyl)methanamine from 2-[[4-(benzyl)-2-morpholinyl]methyl]-1H-isoindole-1,3(2H)-dione: To a 50 mL single-necked round-bottomed flask was added 2-(4-benzylmorpholin-2-yl)methylphthalimide (1.3 g, 3.87 mmol) and hydrazine hydrate (0.38 g, 7.6 mmol) and ethanol (13 mL) was added. The mixture was heated to 80 °C and then stirred for 4 hours. After completion of the reaction, which was monitored by thin layer chromatography (TLC), the resulting solution was cooled to room temperature and filtered to separate the inorganic material. The filtrate was concentrated under vacuum, 10% sodium hydroxide solution (10 mL) was added and extracted twice with dichloromethane (20 mL). All extracted organic layers were combined, dried with anhydrous magnesium sulfate and filtered. The filtrate was concentrated under vacuum to give a solid product. The resulting solid was dried in an oven at 60 °C to give (4-benzylmorpholin-2-yl)methylamine (550 mg, 69% yield). The dried product was used directly in the subsequent reaction.

References

[1] Journal of Medicinal Chemistry, 1990, vol. 33, # 5, p. 1406 - 1413
[2] Journal of Medicinal Chemistry, 1993, vol. 36, # 10, p. 1356 - 1363
[3] Patent: WO2012/128582, 2012, A2. Location in patent: Page/Page column 110
[4] Patent: WO2007/71936, 2007, A1. Location in patent: Page/Page column 86

(4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE Suppliers

Belgium 1 Canada 1 China 96 Germany 3 India 1 Ukraine 2 United Kingdom 6 United States 20 Global 130
UkrOrgSynthesis Ltd.
Tel
--
Fax
--
Email
y.barysheva@ukrorgsynth.com
Country
Ukraine
ProdList
6230
Advantage
38
Enamine
Tel
--
Fax
--
Email
enamine@enamine.net
Country
Ukraine
ProdList
6216
Advantage
67
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View Lastest Price from (4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Mosapride Impurity 22
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-04-10
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Mosapride Impurity 22
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-04-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
(4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE 110859-47-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

110859-47-7, (4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINERelated Search:

(4-BENZYL-1,4-OXAZINAN-2-YL)METHANOL 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine Mosapride citrate (4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE Mosapride 4-BENZYL-2-((PYRROLIDIN-1-YL)METHYL) MORPHOLINE (4-BENZYL-MORPHOLIN-2-YLMETHYL)-DIMETHYL-AMINE (4-BENZYL-MORPHOLIN-2-YLMETHYL)-METHYL-AMINE 4-amino-N-((4-benzyl-2-morpholinyl)-methyl)-5-chloro-2-ethoxybenzamide BUTTPARK 121\16-92 (4-BENZYL-MORPHOLIN-2-YLMETHYL)-ETHYL-AMINE (4-BENZYL-MORPHOLIN-2-YLMETHYL)-DIETHYL-AMINE 4-BENZYL-2-((PIPERIDIN-1-YL)METHYL) MORPHOLINE (2-AMINOMETHYL-MORPHOLIN-4-YL)-PHENYL-METHANONE 4-amino-N-((4-benzyl-2-morpholinyl)methyl)-5-chloro-2-methoxybenzamide N-((4-benzyl-2-morpholinyl)methyl)-5-chloro-4-(dimethylamino)-2-methoxybenzamide BUTTPARK 121\16-91 N-(4-BENZYL-MORPHOLIN-2-YLMETHYL)-2-CHLORO-ACETAMIDE

  • BUTTPARK 85\12-11
  • C-(4-BENZYL-MORPHOLIN-2-YL)-METHYLAMINE
  • (4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE
  • N-methyl-1-(5-methyl-3-isoxazolyl)methanamine
  • 4-Benzyl-2-(aMinoMethyl)Morpholine
  • [[4-(Phenylmethyl)-2-morpholinyl]methyl]amine
  • 1-(4-Benzylmorpholin-2-yl)methanamine
  • (4-BENZYLMORPHOLIN-2-YL) METHANAMINE
  • (4-BENZYLMORPHOLIN-2-YL)METHYLAMINE
  • (4-Benzyl-1,4-oxazinan-2-yl)methylamine 90%
  • (4-Benzyl-1,4-oxazinan-2-yl)methylamine90%
  • 1-[4-(Phenylmethyl)-2-morpholinyl]methanamine
  • 2-Aminomethyl-4-benzylmorpholine
  • (4-benzyl-1,4-oxazinan-2-yl)MethanaMine
  • (4-Benzyl-2-Morpholinyl)MethanaMine
  • 2-MorpholineMethanaMine, 4-(phenylMethyl)-
  • 4-(Benzyl)-2-morpholinemethanamine
  • (4-Benzylmorpholin-2-yl)methylamine95+%
  • 4-(Phenylmethyl)-2-morpholinemethanamine
  • (4-Benzyl-1,4-oxazinan-2-yl)methylamine, 2-(Aminomethyl)-4-benzylmorpholine
  • (4-Benzylmorpholin-2-yl)methylamine 90%
  • Mosapride Impurity 22
  • 110859-47-7
  • pharmacetical
  • Aminomethyl's
  • Morpholines & Thiomorpholines
  • Morpholines & Thiomorpholines
  • DCP