PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE

Product Name: PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE
CAS No.: 207671-42-9
Chemical Name: PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE
Synonyms: LUTIDINIC ACID MONOHYDRATE;PYRIDINE-2,4-DICARBOXYLIC ACID HYDRATE;2,4-PYRIDINECARBOXYLIC ACID MONOHYDRATE;2,4-PYRIDINEDICARBOXYLIC ACID MONOHYDRATE;PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE;2,4-Pyridinedicarboxylicacid, hydrate (1:1);2,4-Pyridinedicarboxylic acid Monohydrate 98%
CBNumber: CB0356837
Molecular Formula: C7H7NO5
Formula Weight: 185.13
MOL File: 207671-42-9.mol

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PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE Property

Melting point:: 246-248 °C (dec.)(lit.)
storage temp.: Store at -20°C
solubility: DMSO: 1.4 mg/ml; PBS (pH 7.2): 0.2 mg/ml
form: A crystalline solid
BRN: 131631

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P63395
Product name: 2,4-Pyridinedicarboxylic acid monohydrate
Purity: 98%
Packaging: 5g
Price: $58.45
Updated: 2025/07/31

Cayman Chemical

Product number: 11138
Product name: 2,4-Pyridinedicarboxylic Acid (hydrate)
Packaging: 1g
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 11138
Product name: 2,4-Pyridinedicarboxylic Acid (hydrate)
Packaging: 5g
Price: $122
Updated: 2024/03/01

TRC

Product number: P992035
Product name: 2,4-Pyridinedicarboxylic acid monohydrate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

TRC

Product number: P992035
Product name: 2,4-Pyridinedicarboxylic acid monohydrate
Packaging: 100mg
Price: $75
Updated: 2021/12/16

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PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE Chemical Properties,Usage,Production

Description

2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl). 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations. Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC₅₀ = 1.5 μM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation. It can inhibit zinc-dependent enzymes, like metallo-β-lactamase. 2,4-PDCA also affects and is translocated by organic anion transporters.

References

[1] Y KIDANI J H. Coordination chemical studies on metalloenzymes. II. Kinetic behavior of various types of chelating agents towards bovine carbonic anhydrase.[J]. Journal of biochemistry, 1977, 81 5: 1383-1391.
[2] M KRISTIAN KOSKI. The active site of an algal prolyl 4-hydroxylase has a large structural plasticity.[J]. The Journal of Biological Chemistry, 2007: 37112-37123. DOI: 10.1074/jbc.m706554200
[3] MUKRAM M. MACKEEN. Small-Molecule-Based Inhibition of Histone Demethylation in Cells Assessed by Quantitative Mass Spectrometry[J]. Journal of Proteome Research, 2010, 9 8: 4082-4092. DOI: 10.1021/pr100269b
[4] ULRIKE LEURS. Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C)[J]. Bioorganic & Medicinal Chemistry Letters, 2012, 22 18: Pages 5811-5813. DOI: 10.1016/j.bmcl.2012.07.091
[5] OLIVER N F KING. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.[J]. PLoS ONE, 2010: e15535. DOI: 10.1371/journal.pone.0015535
[6] LINE H. KRISTENSEN. Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor[J]. The FEBS journal, 2012, 279 11: 1905-1914. DOI: 10.1111/j.1742-4658.2012.08567.x
[7] SHOHEI HAMADA. Design, Synthesis, Enzyme-Inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors[J]. Journal of Medicinal Chemistry, 2010, 53 15: 5629-5638. DOI: 10.1021/jm1003655
[8] L E HORSFALL. Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila.[J]. Antimicrobial Agents and Chemotherapy, 2007: 2136-2142. DOI: 10.1128/aac.00866-06
[9] YOHANNES HAGOS. α-Ketoglutarate-related inhibitors of HIF prolyl hydroxylases are substrates of renal organic anion transporters 1 (OAT1) and 4 (OAT4).[J]. Pflugers Archiv?: European journal of physiology, 2012, 464 4: 367-374. DOI: 10.1007/s00424-012-1140-9

PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE Suppliers

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207671-42-9, PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATERelated Search:

2,2'-Bipyridine-5,5'-dicarboxylic acid 3,4-Pyridinedicarboxylic acid Pyridine-2,4,6-tricarboxylic acid 4,5-Dioxo-4,5-dihydro-1H-pyrrol[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester 7,9-DIMETHOXYCARBONYL-2-ETHOXYCARBONYL-5-METHOXY-1H-PYRROLO-[2,3-F]QUINOLINE 7,9-DIMETHOXYCARBONYL-2-ETHOXYCARBONYL-1H-PYRROLO-[2,3-F]QUINOLINE-4,5-DIONE 4,5-DIHYDRO-4,5-DIOXO-1H-PYRROLO[2,3-F]QUINOLINE-2,7,9-TRICARBOXYLIC ACID, 5,5-DIMETHYL KETAL PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE Pyrroloquinoline quinone TRIMETHYL 5-HYDROXY-2,3,4-PYRIDINETRICARBOXYLATE Pyrroloquinoline quinone disodium salt

PYRIDINE-2,4-DICARBOXYLIC ACID HYDRATE

2,4-PYRIDINEDICARBOXYLIC ACID MONOHYDRATE

2,4-PYRIDINECARBOXYLIC ACID MONOHYDRATE

PYRIDINE-2,4-DICARBOXYLIC ACID MONOHYDRATE

LUTIDINIC ACID MONOHYDRATE

2,4-Pyridinedicarboxylicacid, hydrate (1:1)

2,4-Pyridinedicarboxylic acid Monohydrate 98%

207671-42-9

C7H5NO4H2O

Building Blocks

C7 and C8

Heterocyclic Building Blocks

Pyridines

Building Blocks

C7

Chemical Synthesis

Heterocyclic Building Blocks

C7 and C8

Heterocyclic Building Blocks

Pyridines