ChemicalBook > CAS DataBase List > 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE

2,3-DIFLUORO-6-METHOXYBENZALDEHYDE

Product Name
2,3-DIFLUORO-6-METHOXYBENZALDEHYDE
CAS No.
187543-87-9
Chemical Name
2,3-DIFLUORO-6-METHOXYBENZALDEHYDE
Synonyms
Zavegepant Impurity 56;5,6-Difluoro-o-anisaldehyde;5,6-Difluoro-o-anisaldehyde>2,3-Difluoro-6-methoxybezaldehyde;2,3-DIFLUORO-6-METHOXYBENZALDEHYDE;Benzaldehyde, 2,3-difluoro-6-methoxy-;2,3-Difluoro-6-methoxybenzaldehyde98%;2,3-Difluoro-6-methoxybenzaldehyde 98%;2,3-DIFLUORO-6-METHOXY-BENZALDEHYD, 98+%;3,4-Difluoro-2-formylanisole, 5,6-Difluoro-o-anisaldehyde
CBNumber
CB0357506
Molecular Formula
C8H6F2O2
Formula Weight
172.13
MOL File
187543-87-9.mol
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2,3-DIFLUORO-6-METHOXYBENZALDEHYDE Property

Melting point:
55-57
Boiling point:
233.0±35.0 °C(Predicted)
Density 
1.289±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
color 
White to Light yellow to Light orange
Sensitive 
Air Sensitive
InChI
InChI=1S/C8H6F2O2/c1-12-7-3-2-6(9)8(10)5(7)4-11/h2-4H,1H3
InChIKey
AKOJAYHBKACKNJ-UHFFFAOYSA-N
SMILES
C(=O)C1=C(OC)C=CC(F)=C1F
CAS DataBase Reference
187543-87-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37
Hazard Note 
Irritant/Air Sensitive
HS Code 
29130000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D3885
Product name
5,6-Difluoro-o-anisaldehyde
Purity
>97.0%(GC)
Packaging
1g
Price
$111
Updated
2025/07/31
TCI Chemical
Product number
D3885
Product name
5,6-Difluoro-o-anisaldehyde
Purity
>97.0%(GC)
Packaging
5g
Price
$412
Updated
2025/07/31
TRC
Product number
D448715
Product name
2,3-Difluoro-6-methoxybenzaldehyde
Packaging
500mg
Price
$130
Updated
2021/12/16
Matrix Scientific
Product number
116756
Product name
2,3-Difluoro-6-methoxybenzaldehyde
Packaging
5g
Price
$185
Updated
2021/12/16
SynQuest Laboratories
Product number
2615-3-36
Product name
2,3-Difluoro-6-methoxybenzaldehyde
Purity
98%
Packaging
5G
Price
$295
Updated
2021/12/16
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2,3-DIFLUORO-6-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production

Synthesis

68-12-2

115144-40-6

187543-87-9

a) General procedure for the synthesis of 2,3-difluoro-6-methoxybenzaldehyde: A 2 M solution of diisopropylaminolithium THF/n-heptane (171 mL, 341 mmol) was diluted with dry THF (250 mL) under nitrogen protection and cooled to -75°C. A solution of 3,4-difluoroanisole (46.8 g, 325 mmol) in anhydrous THF (100 mL) was added slowly dropwise and stirred for 1 hour keeping the temperature at -75 °C. Subsequently, dry N,N-dimethylformamide (27.6 mL, 358 mmol) was added slowly and stirring was continued at -70 °C for 10 min. After the reaction was completed, acetic acid (30 mL) and water (400 mL) were added and warmed to 10 °C. The reaction mixture was extracted with ether (2 x 300 mL). The organic phases were combined and washed sequentially with water (250 mL), 0.2N aqueous hydrochloric acid (400 mL) and brine (2 x 250 mL), dried with anhydrous magnesium sulfate, and the solvent was concentrated under reduced pressure to give a red to orange oil, which was allowed to stand and crystallized. Purification by recrystallization from ether/petroleum ether (40-60 °C) afforded the target product 2,3-difluoro-6-methoxybenzaldehyde (53.0 g, 95% yield).1H NMR (300 MHz, CDCl3) δ: 10.40 (1H, s, CHO), 7.37 (1H, q, ArH), 6.71 (1H, m, ArH), 3.93 ( 3H, s, OCH3).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 21, p. 5395 - 5399
[2] Patent: US2009/118546, 2009, A1. Location in patent: Page/Page column 5-6
[3] Patent: WO2004/43904, 2004, A1. Location in patent: Page 39 - 40
[4] Patent: US2011/124686, 2011, A1. Location in patent: Page/Page column 45
[5] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00142

2,3-DIFLUORO-6-METHOXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3-DIFLUORO-6-METHOXYBENZALDEHYDE Suppliers

Americas 1 China 122 Europe 1 France 1 Germany 2 India 4 Italy 1 Japan 2 The Netherlands 1 United Kingdom 16 United States 27 Global 178
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View Lastest Price from 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2,3-DIFLUORO-6-METHOXYBENZALDEHYDE 187543-87-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-03-29
SHAANXI LIGHTE OPTOELECTRONICS MATERIAL CO., LTD
Product
2,3-DIFLUORO-6-METHOXYBENZALDEHYDE 187543-87-9
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99%HPLC
Supply Ability
20 tons
Release date
2022-11-09
Shanghai Rlavie Technology Co ltd
Product
5,6-Difluoro-o-anisaldehyde 187543-87-9
Price
US $0.00-0.00/kg
Min. Order
0.0001kg
Purity
98%min
Supply Ability
100kgs/month
Release date
2022-05-10

187543-87-9, 2,3-DIFLUORO-6-METHOXYBENZALDEHYDERelated Search:

2,3-Difluoro-4-methoxybenzaldehyde 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE 2,5-DIFLUORO-4-METHOXYBENZALDEHYDE 4,5-DIFLUORO-2-METHOXYBENZALDEHYDE 3,5-Difluoro-4-methoxybenzaldehyde 99%,3,5-Difluoro-4-methoxybenzaldehyde99%,3,5-DIFLUORO-4-METHOXYBENZALDEHYDE R547 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE 2,3-DIFLUORO-4-METHOXYBENZOIC ACID 2,6-Difluoro-3-methoxyBenzaldehyde 3,5-DIFLUORO-2-METHOXYBENZALDEHYDE 2,4-DIFLUORO-3-METHOXYBENZALDEHYDE 2,3-DIFLUORO-6-METHOXYBENZOYL CHLORIDE 2,5-DIFLUORO-4-METHOXYBENZALDEHYDE 2,3-DIFLUORO-6-METHOXYBENZAMIDE 3,6-DIFLUORO-2-METHOXYBENZALDEHYDE 2,6-DIFLUORO-3-METHOXYBENZALDEHYDE 4,5-DIFLUORO-3-METHOXYBENZALDEHYDE RARECHEM AL BI 1275

  • 5,6-Difluoro-o-anisaldehyde
  • 2,3-Difluoro-6-methoxybezaldehyde
  • 3,4-Difluoro-2-formylanisole, 5,6-Difluoro-o-anisaldehyde
  • 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE
  • 2,3-Difluoro-6-methoxybenzaldehyde 98%
  • 2,3-Difluoro-6-methoxybenzaldehyde98%
  • 2,3-DIFLUORO-6-METHOXY-BENZALDEHYD, 98+%
  • 5,6-Difluoro-o-anisaldehyde&gt
  • Benzaldehyde, 2,3-difluoro-6-methoxy-
  • Zavegepant Impurity 56
  • 187543-87-9
  • Fluorine series
  • Benzaldehyde
  • Aromatic Aldehydes & Derivatives (substituted)