CFTRinh-172
- Product Name
- CFTRinh-172
- CAS No.
- 307510-92-5
- Chemical Name
- CFTRinh-172
- Synonyms
- CS-1067;CFTR(INH)-172;CFTR INHIBITOR-172;CFTRinh-172 USP/EP/BP;InSolution? CFTR Inhibitor-172;CFTR INHIBITOR-172;CFTRINH-172;CFTRinh 172 (CFTR Inhibitor-172);CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem;InSolution CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem;4-[[4-Oxo-2-Thioxo-3-[3-(Trifluoromethyl)Phenyl]Thiazolidin-
- CBNumber
- CB0364629
- Molecular Formula
- C18H10F3NO3S2
- Formula Weight
- 409.4
- MOL File
- 307510-92-5.mol
CFTRinh-172 Property
- Melting point:
- 181-183 °C
- Boiling point:
- 555.7±60.0 °C(Predicted)
- Density
- 1.61±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥10mg/mL
- form
- Yellow solid
- pka
- 3.88±0.10(Predicted)
- color
- yellow
- CAS DataBase Reference
- 307510-92-5
Safety
- Hazard Codes
- Xi,N
- Risk Statements
- 36/37/38-43-50/53
- Safety Statements
- 26-36/37-60-61
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 219670
- Product name
- CFTR Inhibitor-172
- Packaging
- 5mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- 219674
- Product name
- InSolution? CFTR Inhibitor-172
- Packaging
- 5mg
- Price
- $195
- Updated
- 2023/01/07
- Product number
- 15545
- Product name
- CFTR Inhibitor-172
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 15545
- Product name
- CFTR Inhibitor-172
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- C2992
- Product name
- CFTR(inh)-172
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $191
- Updated
- 2024/03/01
CFTRinh-172 Chemical Properties,Usage,Production
Uses
The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). CFTR Inhibitor-172 is a thiazolidinone that selectively blocks the CFTR channel (Ki = 300 nM) in a voltage-independent manner. It appears to directly modulate the gating of chloride at the channel and does not prevent elevation of cAMP or inhibit other pumps or channels. In mice, CFTR inhibitor-172 prevents cholera toxin-induced fluid secretion in the small intestine, when given by intraperitoneal injection. It slows cyst growth in animal models of polycystic kidney disease. As CFTR also modulates glutathione (GSH) efflux, CFTR inhibitor-172 can affect intracellular GSH concentration and reactive oxygen species balance.
Uses
CFTR(inh)-172 has been used to specifically inhibit cystic fibrosis transmembrane conductance regulator (CFTR) activity. It is also used as a CFTR inhibitor Inh-172 to treat forskolin and IBMX.
Definition
ChEBI: A thiazolidinone that is 2-thioxo-4-thiazolidinone which is substituted at position 3 by a (m--trifluoromethyl)phenyl group and at position 5 by a p-carboxybenzylidene group. It is an inhibitor of cystic fibrosis transmembrane con uctance regulator, a membrane protein and chloride channel in vertebrates that is encoded by the CFTR gene.
Biological Activity
Voltage-independent, selective CFTR chloride channel blocker (K i = 300 nM) that alters channel gating. Blocks intestinal fluid secretion induced by cholera toxin and Escherichia coli and suppresses cyst growth in animal models of polycystic kidney disease. Orally active. Inhibits mitochondrial respiration and increases reactive oxygen species (ROS) production independently of CFTR in several cell lines.
Biochem/physiol Actions
CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR). With a Ki = 300 nM,. CFTR(inh)-172 leads to rapid, reversible and voltage-independent inhibition; it is an antidiarrheal agent in animals. CTFR(inh)-172 may be a useful tool to study animal models of cystic fibrosis and intestinal fluid loss in cholera and other secretory diarrheas. CTFR(inh)-172 is structurally-unrelated to known, but non-specific CFTR inhibitors DPC, NPPB (Cat. No. N4779) and Glibenclamide.
in vitro
cftrinh-172 could reversibly inhibit cftr short-circuit current in less than 2 minutes in a voltage-independent manner. moreover, at concentrations fully inhibiting cftr, cftrinh-172 did not prevent elevation of cellular camp or inhibit non-cftr cl–channels, multidrug resistance protein-1, atp-sensitive k+ channels, or a series of other transporters [2].
in vivo
a single ip injection of cftrinh-172 (250 μg/kg) in mice reduced by more than 90% cholera toxin–induced fluid secretion in the small intestine over 6 hours. cftrinh-172 may be useful in developing large-animal models of cystic fibrosis and reducing intestinal fluid loss in cholera and other secretory diarrheas [3].
storage
Store at +4°C
References
[1] ma t, thiagarajah jr, yang h, sonawane nd, folli c, galietta lj, verkman as. thiazolidinone cftr inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. j clin invest. 2002 dec;110(11):1651-8.
CFTRinh-172 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CFTRinh-172 manufacturers
- Product
- CFTRinh-172 307510-92-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23