ChemicalBook > CAS DataBase List > ARG-GLY-ASP

ARG-GLY-ASP

Product Name
ARG-GLY-ASP
CAS No.
99896-85-2
Chemical Name
ARG-GLY-ASP
Synonyms
RGD;F-336;H2N-RGD-OH;ARG-GLY-ASP;L-ARG-GLY-ASP;H-ARG-GLY-ASP-OH;RGD (Arg-Gly-Asp);Arg-Gly-Asp (TLC);RGD PEPTIDE (CORE);Arg-Gly-Asp acetate
CBNumber
CB0364876
Molecular Formula
C12H22N6O6
Formula Weight
346.34
MOL File
99896-85-2.mol
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ARG-GLY-ASP Property

Melting point:
153-155℃ (ethyl ether )
Density 
1.61±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in 0.1N acetic acid at 20mg/ml
pka
2.85±0.10(Predicted)
form 
Powder
Water Solubility 
Soluble to 12 mg/mL (34.64 mM) in Water
InChIKey
IYMAXBFPHPZYIK-BQBZGAKWSA-N
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A8052
Product name
Arg-Gly-Asp
Purity
≥97% (TLC)
Packaging
1mg
Price
$34.7
Updated
2024/03/01
Sigma-Aldrich
Product number
A8052
Product name
Arg-Gly-Asp
Purity
≥97% (TLC)
Packaging
5mg
Price
$101
Updated
2024/03/01
Alfa Aesar
Product number
J65468
Product name
Arg-Gly-Asp
Packaging
5mg
Price
$164
Updated
2023/06/20
Sigma-Aldrich
Product number
A8052
Product name
Arg-Gly-Asp
Purity
≥97% (TLC)
Packaging
10mg
Price
$182
Updated
2024/03/01
Usbiological
Product number
260168
Product name
Arg-Gly-Asp
Packaging
50mg
Price
$305
Updated
2021/12/16
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ARG-GLY-ASP Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

Arg-Gly-Asp has been used:

  • to saturate the cell surface Arg-Gly-Asp (RGD) receptors and inhibit marrow stromal cell (MSC) attachment to peptide modified hydrogel
  • in adhesion assay
  • in inhibition assay to confirm the β1-integrin-dependency of cell adhesion
  • in textile fabrication and RGD textile functionalization
  • to engineer a population of human dermal fibroblasts with impaired migration
  • to modify glass substrate and evaluate the behavior of human bone marrow mesenchymal stem cells (hBM-MSCs)
  • in the cell culture of human mammary epithelial cells

Definition

ChEBI: Arg-Gly-Asp is an oligopeptide.

General Description

Arg-Gly-Asp (RGD) is an integrin binding site, which belongs to the class of adhesive proteins. It functions as a brain tumor targeting ligand.

Biological Activity

synthetic peptides containing the arginine-glycine-aspartate (rgd) were extensively used as inhibitors of integrin-ligand interactions in studies of cell adhesion, migration, growth and differentiation, since the rgd motif is an integrin-recognition motif found in many ligands.

Biochem/physiol Actions

Primary sequence involved with the binding of proteins to cell surfaces

in vitro

rgd peptide can induce apoptosis in the absence of signals and integrin-mediated cell clustering. previous study demonstrates that rgd peptides promote apoptosis through activation of conformation changes enhancing pro-caspase-3 activation and autoprocessing [1].

in vivo

anima study suggested that the rgd-4c-fitc-peptide bound to both endothelial and tumor cells in vivo and that peptide targeting should allow the delivery of therapeutic drugs to both endothelial and tumor cells [2].

target

integrin-ligand interaction

storage

Store at -20°C

References

[1] nature. 1999 feb 11;397(6719):534-9.rgd peptides induce apoptosis by direct caspase-3 activation. buckley cd1, pilling d, henriquez nv, parsonage g, threlfall k, scheel-toellner d, simmons dl, akbar an, lord jm, salmon m.
[2] cancer res. 2002 sep 15;62(18):5139-43. arginine-glycine-aspartic acid (rgd)-peptide binds to both tumor and tumor-endothelial cells in vivo. zitzmann s1, ehemann v, schwab m.

ARG-GLY-ASP Preparation Products And Raw materials

Raw materials

Preparation Products

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ARG-GLY-ASP Suppliers

China 151 China Hong Kong 1 France 1 Germany 3 India 1 Japan 2 Switzerland 1 United Kingdom 4 United States 21 Global 185
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View Lastest Price from ARG-GLY-ASP manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
ARG-GLY-ASP 99896-85-2
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-13
Hebei Xinsheng New Material Technology Co., LTD.
Product
Arg-Gly-Asp
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20tons
Release date
2023-08-22
Zibo Hangyu Biotechnology Development Co., Ltd
Product
Arginyl-glycyl-aspartic acid 99896-85-2
Price
US $90.00-900.00/KG
Min. Order
1KG
Purity
0.98
Supply Ability
20 tons
Release date
2023-10-25

99896-85-2, ARG-GLY-ASPRelated Search:

L-Glutamic acid, N-(N-L-arginylglycyl)- H-ARG-GLY-ASP-VAL-OH L-ARG-GLY-ASP-SER,H-ARG-GLY-ASP-SER-OH THYMOPOIETIN II (32-34) H-GLY-ARG-GLY-ASP-SER-PRO-LYS-OH H-GLY-ARG-GLY-ASP-SER-PRO-CYS-OH H-GLY-ARG-GLY-ASP-SER-OH GLY-PEN-GLY-ARG-GLY-ASP-SER-PRO-CYS-ALA H-ALA-CYS-ASP-CYS-ARG-GLY-ASP-CYS-PHE-CYS-GLY-OH (DISULFIDE BRIDGE: 2-10 AND 4-8) H-ARG-GLY-ASP-CYS-OH H-ARG-ARG-GLY-ASP-MET-GLU-OH H-GLY-ARG-GLY-ASP-THR-PRO-OH,GLY-ARG-GLY-ASP-THR-PRO H-GLY-ARG-GLY-ASP-ASN-PRO-OH SAR-ARG-GLY-ASP-SER-PRO,SAR-ARG-GLY-ASP-SER-PRO-OH TRP-ASN-ARG-GLN-LEU-TYR-PRO-GLU-TRP-THR-GLU-ALA-GLN-ARG-LEU-ASP ARG-GLY-ASP HIS-GLN-VAL-SER-LEU-SER-LYS-GLN-PRO-THR-SER-GLN-PRO-ARG-GLY-ASP H-GLY-ARG-GLY-ASP-OH

  • H2N-RGD-OH
  • H-ARG-GLY-ASP-OH
  • L-ARG-GLY-ASP
  • ARGINYL-GLYCYL-ASPARTIC ACID
  • ARG-GLY-ASP
  • ARG-GLY-ASP PEPTIDE
  • Arg-Gly-Asp acetate
  • Arginyl-glycyl-asparagilin
  • F-336
  • L-Aspartic acid, N-(N-L-arginylglycyl)-
  • N-(N-L-Arginylglycyl)-L-aspartic acid
  • Rgd tripeptide sequence
  • RGD (Arg-Gly-Asp) Peptides
  • Arginyl - glycyl - aspartate
  • L-Arginylglycyl-L-aspartic acid
  • RGD
  • RGD PEPTIDE (CORE)
  • L-Aspartic acid, L-arginylglycyl-
  • H-Arg-Gly-Asp-OH≥ 98% (HPLC)
  • Arg-Gly-Asp, ≥97% (HPLC)
  • Arg-Gly-Asp >=97% (TLC)
  • ARG-GLY-ASP USP/EP/BP
  • (S)-2-(2-((S)-2-Amino-5-guanidinopentanamido)acetamido)succinic acid
  • RGD (Arg-Gly-Asp)
  • Arg-Gly-Asp (TLC)
  • Integrin,RGD,inhibit,Inhibitor
  • 99896-85-2
  • C12H22N6O6
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Extracellular Matrix
  • Extracellular Matrix Peptides and Proteins
  • Cytoskeleton and Extracellular Matrix
  • BioChemical
  • Peptide
  • Cell Signaling Enzymes
  • ECM ProteinsCytoskeleton and Extracellular Matrix
  • Extracellular Matrix
  • Extracellular Matrix Peptides (ECM)
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