ARG-GLY-ASP
- Product Name
- ARG-GLY-ASP
- CAS No.
- 99896-85-2
- Chemical Name
- ARG-GLY-ASP
- Synonyms
- RGD;F-336;H2N-RGD-OH;ARG-GLY-ASP;L-ARG-GLY-ASP;H-ARG-GLY-ASP-OH;RGD (Arg-Gly-Asp);Arg-Gly-Asp (TLC);RGD PEPTIDE (CORE);Arg-Gly-Asp acetate
- CBNumber
- CB0364876
- Molecular Formula
- C12H22N6O6
- Formula Weight
- 346.34
- MOL File
- 99896-85-2.mol
ARG-GLY-ASP Property
- Melting point:
- 153-155℃ (ethyl ether )
- Density
- 1.61±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in 0.1N acetic acid at 20mg/ml
- pka
- 2.85±0.10(Predicted)
- form
- Powder
- color
- White to off-white
- Water Solubility
- Soluble to 12 mg/mL (34.64 mM) in Water
- InChIKey
- IYMAXBFPHPZYIK-BQBZGAKWSA-N
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A8052
- Product name
- Arg-Gly-Asp
- Purity
- ≥97% (TLC)
- Packaging
- 1mg
- Price
- $34.7
- Updated
- 2024/03/01
- Product number
- A8052
- Product name
- Arg-Gly-Asp
- Purity
- ≥97% (TLC)
- Packaging
- 5mg
- Price
- $101
- Updated
- 2024/03/01
- Product number
- J65468
- Product name
- Arg-Gly-Asp
- Packaging
- 5mg
- Price
- $164
- Updated
- 2023/06/20
- Product number
- A8052
- Product name
- Arg-Gly-Asp
- Purity
- ≥97% (TLC)
- Packaging
- 10mg
- Price
- $182
- Updated
- 2024/03/01
- Product number
- 260168
- Product name
- Arg-Gly-Asp
- Packaging
- 50mg
- Price
- $305
- Updated
- 2021/12/16
ARG-GLY-ASP Chemical Properties,Usage,Production
Chemical Properties
White to off-white powder
Uses
Arg-Gly-Asp has been used:
- to saturate the cell surface Arg-Gly-Asp (RGD) receptors and inhibit marrow stromal cell (MSC) attachment to peptide modified hydrogel
- in adhesion assay
- in inhibition assay to confirm the β1-integrin-dependency of cell adhesion
- in textile fabrication and RGD textile functionalization
- to engineer a population of human dermal fibroblasts with impaired migration
- to modify glass substrate and evaluate the behavior of human bone marrow mesenchymal stem cells (hBM-MSCs)
- in the cell culture of human mammary epithelial cells
Definition
ChEBI: Arg-Gly-Asp is an oligopeptide.
General Description
Arg-Gly-Asp (RGD) is an integrin binding site, which belongs to the class of adhesive proteins. It functions as a brain tumor targeting ligand.
Biological Activity
synthetic peptides containing the arginine-glycine-aspartate (rgd) were extensively used as inhibitors of integrin-ligand interactions in studies of cell adhesion, migration, growth and differentiation, since the rgd motif is an integrin-recognition motif found in many ligands.
Biochem/physiol Actions
Primary sequence involved with the binding of proteins to cell surfaces
in vitro
rgd peptide can induce apoptosis in the absence of signals and integrin-mediated cell clustering. previous study demonstrates that rgd peptides promote apoptosis through activation of conformation changes enhancing pro-caspase-3 activation and autoprocessing [1].
in vivo
anima study suggested that the rgd-4c-fitc-peptide bound to both endothelial and tumor cells in vivo and that peptide targeting should allow the delivery of therapeutic drugs to both endothelial and tumor cells [2].
target
integrin-ligand interaction
storage
Store at -20°C
References
[1] nature. 1999 feb 11;397(6719):534-9.rgd peptides induce apoptosis by direct caspase-3 activation. buckley cd1, pilling d, henriquez nv, parsonage g, threlfall k, scheel-toellner d, simmons dl, akbar an, lord jm, salmon m.
[2] cancer res. 2002 sep 15;62(18):5139-43. arginine-glycine-aspartic acid (rgd)-peptide binds to both tumor and tumor-endothelial cells in vivo. zitzmann s1, ehemann v, schwab m.
ARG-GLY-ASP Preparation Products And Raw materials
Raw materials
Preparation Products
ARG-GLY-ASP Suppliers
- Tel
- --
- Fax
- --
- neo@neomps.com
- Country
- France
- ProdList
- 2083
- Advantage
- 71
View Lastest Price from ARG-GLY-ASP manufacturers
- Product
- Arg-Gly-Asp 99896-85-2
- Price
- US $40.00-35.00/Box
- Min. Order
- 1Box
- Purity
- 99%
- Supply Ability
- 1000 boxs
- Release date
- 2024-07-04
- Product
- Arginyl-glycyl-aspartic acid 99896-85-2
- Price
- US $90.00-900.00/KG
- Min. Order
- 1KG
- Purity
- 0.98
- Supply Ability
- 20 tons
- Release date
- 2023-10-25
- Product
- ARG-GLY-ASP 99896-85-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-13