L-Camphorsulfonic acid Uses Production method
ChemicalBook > CAS DataBase List > (1R)-(-)-10-Camphorsulfonic acid

(1R)-(-)-10-Camphorsulfonic acid

L-Camphorsulfonic acid Uses Production method
Product Name
(1R)-(-)-10-Camphorsulfonic acid
CAS No.
35963-20-3
Chemical Name
(1R)-(-)-10-Camphorsulfonic acid
Synonyms
(-)-CSA;(1R)-(-)-CAMPHOR-10-SULFONIC ACID;((1R,4S)-7,7-DiMethyl-2-oxobicyclo[2.2.1]heptan-1-yl)Methanesulfonic acid;(-)-10-CSA;L-(-)-CAMPHORSULFONIC ACID;(-)-10-CAMPHORSULFONIC ACID;d-Camphor-10-sulphonic acid;(-)-10-Camphorsulfonic Acid;(1R)-CAMPHOR-10-SULFONIC ACID;L-10-(-)-CAMPHOR SULFONIC ACID
CBNumber
CB0365888
Molecular Formula
C10H16O4S
Formula Weight
232.3
MOL File
35963-20-3.mol
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(1R)-(-)-10-Camphorsulfonic acid Property

Melting point:
198 °C (dec.)(lit.)
alpha 
-22 º (c=20,H2O)
Boiling point:
344.46°C (rough estimate)
Density 
1.2981 (rough estimate)
refractive index 
-21.5 ° (C=5, H2O)
storage temp. 
Store below +30°C.
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
pka
1.17±0.50(Predicted)
form 
Crystalline Powder
color 
White to slightly beige
PH
1.2-1.4 (20g/l, H2O)
optical activity
[α]20/D 21°, c = 2 in H2O
Water Solubility 
soluble
Sensitive 
Hygroscopic
BRN 
2809676
Stability:
Stable. Hygroscopic. Incompatible with strong bases, strong oxidizing agents.
InChIKey
MIOPJNTWMNEORI-XVKPBYJWSA-N
CAS DataBase Reference
35963-20-3(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45-24/25-27
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
F 
3-10
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29147090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.40094
Product name
(1R)-(-)-Camphor-10-sulfonic acid
Purity
for synthesis
Packaging
100g
Price
$177
Updated
2024/03/01
Sigma-Aldrich
Product number
21365
Product name
(?)-Camphor-10-sulfonic acid
Purity
purum,≥98.0%(T)
Packaging
50g
Price
$99.5
Updated
2024/03/01
Sigma-Aldrich
Product number
21365
Product name
(?)-Camphor-10-sulfonic acid
Purity
purum,≥98.0%(T)
Packaging
250g
Price
$344
Updated
2024/03/01
TCI Chemical
Product number
C0972
Product name
(-)-10-Camphorsulfonic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$30
Updated
2024/03/01
TCI Chemical
Product number
C0972
Product name
(-)-10-Camphorsulfonic Acid
Purity
>98.0%(T)
Packaging
100g
Price
$71
Updated
2024/03/01
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(1R)-(-)-10-Camphorsulfonic acid Chemical Properties,Usage,Production

L-Camphorsulfonic acid

Camphor sulfonic acid includes L-camphor sulfonic acid, D-camphor sulfonic acid and racemic camphor sulfonic acid these three isomers.
It is a kind of white columnar crystals with the melting point of 193°C (decomposition). [α]D20+24° (water). It is Slightly soluble in ethanol, insoluble in ether, soluble in sodium hydroxide and sodium carbonate solution. L-camphor sulfonic acid could be produced from reaction between camphor, sulfuric acid and acetic anhydride.It has a lot of functions such as exciting the respiratory center, the vascular movement center and myocardium. Its sodium salt plays pharmaceutical role in medicine.
Camphor sulfonic acid sodium salt is a kind of white crystalline powder. It is odorless and tastes bitter and then sweet. It is easily absorb moisture and easily dissolve in the water and hot ethanol. So it should be shading confined preservation. it can Directly excite the medulla oblongata respiratory center and vascular movement center, and quicken and deepen the breath, rise the blood pressure; it also can directly excite the myocardium and strength the contraction of cardiac muscle as well as could increase the output.
It is applied the treatment of infectious disease, as well as the disease like central inhibition of poisoning caused by respiratory depression, fatigue, high fever, poisoning, heat stroke and other acute heart failure.

Uses

(1) It is also used for the racemization of optical isomers.
(2) It can be applied to the resolution of intermediate or isomer in medicine.
(3) It also could play a role as organic synthesis intermediates and resolving agent.

Production method

Camphor sulfonic acid is obtained from camphor and sulfuric acid by irradiation.
This method involves:
1) Adding the camphor and acetic anhydride to the pot.
2) Mixing it and making it dissolved.
3) Dripping sulfuric acid after cooling. And the reaction should be maintained at 44-45 °C for 48 hours. Then cool it to 6-7 °C.
4) Crystallizing, filtrating, washing with a small amount of acetic acid crystals, and dry it to get camphor sulfonic acid.

Physical properties

(1R)-(-)-10-Camphorsulfonic acid is a kind of prismatic crystals and its melting point is 193-195 ° C (decompose). It is Insoluble in ether and slightly soluble in glacial acetic acid and ethyl acetate. And it is and moisture in wet air.

Uses

(1R)-(-)-Camphor-10-sulfonic acid, is used as a pharamaceutical intermediate and also used as a chiral derivative of Camp. It can also be used as resolving agents for chiral amines and other cations.

Uses

1R)-(-)-10-Camphorsulfonic acid is a chiral derivative of Camphor.It has the following uses:
(1)It is also used for the racemization of optical isomers.
(2) It can be applied to the resolution of intermediate or isomer in medicine.
(3) It also could play a role as organic synthesis intermediates and resolving agent.

Definition

ChEBI: The R enantiomer of camphorsulfonic acid.

General Description

(1R)-(-)-10-Camphorsulfonic acid is an HPLC derivatization reagent for UV/Vis detection. It is mainly employed for the resolution of bases.

Purification Methods

It forms prisms from AcOH or EtOAc, and is deliquescent in moist air. Store it in tightly stoppered bottles. The NH4 salt forms needles from H2O [] D ±20.5o (c 5, H2O). [Burgess & Lowry J Chem Soc 127 279 1925, Marsi et al. J Am Chem Soc [ 78 3063 1956.] The RS-acid recrystallises from AcOH. [60g of (±)-acid in 60mL of AcOH at 105o gave 40g of crystals has m 202-203o [Bartlett & Knox Org Synth 45 12 1965.] [Beilstein 11 IV 642.]

(1R)-(-)-10-Camphorsulfonic acid Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-(-)-3-Quinuclidinol GERANYL BUTYRATE (R)-4-Boc-Piperazine-3-carboxylic acid polyaniline composite film (R)-PIPERAZINE-2-CARBOXYLIC ACID (R)-3-Quinuclidinol hydrochloride
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View Lastest Price from (1R)-(-)-10-Camphorsulfonic acid manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
(1R)-(-)-10-Camphorsulfonic acid 35963-20-3
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-22
airuikechemical co., ltd.
Product
l-10-camphorsulfonic acid 35963-20-3
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-03-28
Hebei Chuanghai Biotechnology Co,.LTD
Product
CAMPHORSULFONIC ACID 35963-20-3
Price
US $8.00/kg
Min. Order
10kg
Purity
99%
Supply Ability
10000kg
Release date
2024-08-22

35963-20-3, (1R)-(-)-10-Camphorsulfonic acidRelated Search:

Dimethyl ether ETHANE Camphor Sodium 1-heptanesulfonate Dimethyl sulfide Dimethyl sulfoxide Taurine Heptane N,N-Dimethylformamide Sulfamic acid 1-DODECANESULFONIC ACID SODIUM SALT p-Toluenesulfonic acid Pefloxacin mesylate Citric acid Methanesulfonic acid Folic acid Glycine Dimethyl fumarate

  • (-)-CAMPHOR-10-SULPHONIC ACID
  • (-)-CAMPHOR-10-SULFONIC ACID
  • L-10-(-)-CAMPHOR SULFONIC ACID
  • L-(-)-CAMPHORSULFONIC ACID
  • L-(+)-CAMPHOR SULFONIC ACID
  • L(+)-CAMPHORSULPHONIC ACID
  • L-CAMPHORSULPHONIC ACID
  • L-(-)-CAMPHOR-10-SULFONIC ACID
  • (1R)-(-)-CAMPHOR-10-SULPHONIC ACID
  • (1R)-(-)-CAMPHOR-10-SULFONIC ACID
  • (1R)-CAMPHOR-10-SULFONIC ACID
  • (1R)-(-)-CAMPHORSULFONIC ACID
  • (1r)-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulphonic acid
  • (1R)-(-)-10-CAMPHORSULFONIC ACID
  • (-)-10-CAMPHORSULFONIC ACID
  • Voriconazole Related Compound 11
  • 2-Oxo-10-bornane-sulfonicacid
  • 7,7-Dimethyl-2-oxobicyclo[2,2,1]heptane-1-methane-sulfonicacid
  • Camphor-sulphonicacid
  • Voriconazole Related CoMpound F
  • (1R)-(-)-10-Camphosulfonic acid
  • L - Campho 10 Sulphonic Acid
  • (1R)-(-)-Camphor-10-sulfonic acid, 98+%
  • CLOPIDOGREL INTERMEDIATES
  • d-Camphor-10-sulphonic acid
  • (1R)-(-)-CAMPHOR-10-SULPHONIC ACID 99%
  • S-(-)-CAMPHORSULFONIC ACID
  • (1R)-(-)-CAMPHER-10-SULFONSURE
  • Voriconazole EP Impurity E (1R)-Isomer
  • )-Camphor-10-sulfonic acid (1R)-Camphor-10-sulfonic acid L(-)-Camphorsulfonic acid
  • (1R)-(-)-Camphor-10-sulfonic acid for synthesis
  • [(1S,4R)-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid
  • (1R)-(-)-10-CaMphorsulfonic acid 98%
  • L- caMphor sulfonic acid (L-caMphor sulfonic acid)
  • L(-)-Camphorsulfonic acid 1R-(-)-10-Camphorsulfonic acid
  • (-)-10-CSA
  • [(4R)-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid
  • Camphor Impurity 3（(1R)-10-Camphorsulfonic Acid）
  • (-)-CamphorsuL
  • (-)-Camphor-10-sulfonic acid, (1R)-(-)-Camphor-10-sulfonic acid, (1R)-Camphor-10-sulfonic acid
  • (-)-(1R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid
  • Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1R,4S)-
  • (1R,4S)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid
  • (1R,4S)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptane-1α-methanesulfonic acid
  • [1R,4S,(-)]-2-Oxobornane-10-sulfonic acid
  • [1R,4S,(-)]-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid
  • (1R)-Camphor-10-sulfonic acid L(-)-Camphorsulfonic acid
  • (-)-10-Camphorsulfonic acid ,99%
  • ()-Camphor-10-sulfonic acid,(1R)-()-Camphor-10-sulfonic acid
  • (1R)-()-10-Camphorsulfonic acid,()-Camphor-10-sulfonic acid, (1R)-()-Camphor-10-sulfonic acid, (1R)-Camphor-10-sulfonic acid
  • L(-)-Camphorsulfonic
  • L(-)-Camphorsulfonic acid,98%
  • (1R)-(-)-CAMPHOR-10-SULPHONIC ACIDCaMphorSulfonic Acid
  • L(-)-CaMphorsulfonic acid, 98% 5GR
  • ((1R,4S)-7,7-DiMethyl-2-oxobicyclo[2.2.1]heptan-1-yl)Methanesulfonic acid
  • (R)-()-10-CaMphorsulfonic acid
  • (-)-10-Camphorsulfonic acid, 99%, reagent grade
  • (-)-10-Camphorsulfonic Acid &gt