5-Bromo-2-iodo-3-methylpyridine
- Product Name
- 5-Bromo-2-iodo-3-methylpyridine
- CAS No.
- 376587-52-9
- Chemical Name
- 5-Bromo-2-iodo-3-methylpyridine
- Synonyms
- 5-bromo-2-indo-methylpyridine;5-BROMO-2-IODO-3-METHYLPYRIDINE;Pyridine, 5-bromo-2-iodo-3-methyl-;2-Iodine-3-Methyl-5-Bromo Pyridine;5-Bromo-2-iodo-3-methylpyridine ISO 9001：2015 REACH
- CBNumber
- CB0374879
- Molecular Formula
- C6H5BrIN
- Formula Weight
- 297.92
- MOL File
- 376587-52-9.mol
5-Bromo-2-iodo-3-methylpyridine Property
- Boiling point:
- 279.9±35.0 °C(Predicted)
- Density
- 2.171±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -0.22±0.20(Predicted)
- Appearance
- Colorless to light yellow Solid-Liquid Mixture
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FB151282
- Product name
- 5-Bromo-2-iodo-3-methylpyridine
- Packaging
- 50mg
- Price
- $51
- Updated
- 2021/12/16
- Product number
- FB151282
- Product name
- 5-Bromo-2-iodo-3-methylpyridine
- Packaging
- 100mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- Z0555
- Product name
- 5-Bromo-2-iodo-3-picoline
- Packaging
- 100mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- FB151282
- Product name
- 5-Bromo-2-iodo-3-methylpyridine
- Packaging
- 250mg
- Price
- $177.5
- Updated
- 2021/12/16
- Product number
- FB151282
- Product name
- 5-Bromo-2-iodo-3-methylpyridine
- Packaging
- 500mg
- Price
- $310
- Updated
- 2021/12/16
5-Bromo-2-iodo-3-methylpyridine Chemical Properties,Usage,Production
Uses
5-Bromo-2-iodo-3-methylpyridine can be used as NADPH oxidase inhibitors useful in treatment and prophylaxis of NOX-mediated diseases.
Synthesis
3430-18-0
376587-52-9
2,5-Dibromo-3-methylpyridine (M-12) (5.02 g, 20.0 mmol) was used as a raw material and dissolved in acetonitrile (50 mL). Subsequently, sodium iodide (12.0 g, 80.0 mmol) and acetyl chloride (2.85 mL, 40.0 mmol) were sequentially added to this solution. The reaction mixture was heated and stirred under reflux conditions for 24 hours. Upon completion of the reaction, it was cooled to room temperature, diluted with an appropriate amount of water and the pH was adjusted to 8 with saturated aqueous sodium bicarbonate solution to neutralize the reaction mixture. Extraction was carried out with ethyl acetate, the organic layer was collected and dried over anhydrous sodium sulfate, and the desiccant was removed by filtration. The solvent was removed by concentration under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent ratio: n-hexane/ethyl acetate=98:2→70:30) to afford the target product 5-bromo-2-iodo-3-methylpyridine (M-13) (5.76 g, 97% yield) as a red oil.
References
[1] Patent: EP3351533, 2018, A1. Location in patent: Paragraph 0321; 0322
[2] Patent: JP2018/145180, 2018, A. Location in patent: Paragraph 0315; 0316; 0317
[3] Patent: WO2014/39484, 2014, A1. Location in patent: Page/Page column 40; 41
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2016, vol. 55B, # 9, p. 1117 - 1130
[5] Journal of the American Chemical Society, 2017, vol. 139, # 49, p. 18016 - 18023
5-Bromo-2-iodo-3-methylpyridine Preparation Products And Raw materials
Raw materials
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View Lastest Price from 5-Bromo-2-iodo-3-methylpyridine manufacturers
- Product
- 5-Bromo-2-iodo-3-methylpyridine 376587-52-9
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 5-Bromo-2-iodo-3-methylpyridine 376587-52-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-23
- Product
- 5-Bromo-2-iodo-3-methylpyridine 376587-52-9
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-12