3-Picolyl chloride hydrochloride
- Product Name
- 3-Picolyl chloride hydrochloride
- CAS No.
- 6959-48-4
- Chemical Name
- 3-Picolyl chloride hydrochloride
- Synonyms
- 3-(CHLOROMETHYL)PYRIDINE HYDROCHLORIDE;nci-c03838;3-pyridine. HCl;WLN: T6NJ C1G &GH;3-PicolylChlorideHcl;3-Picolyl chloride h;Rupatadine impurity 10;Rupatadine Impurity 7 HCl;Rupatadine Impurity 4 HCl;Rupatadine Impurity 2 HCl
- CBNumber
- CB0374970
- Molecular Formula
- C6H7Cl2N
- Formula Weight
- 164.03
- MOL File
- 6959-48-4.mol
3-Picolyl chloride hydrochloride Property
- Melting point:
- 137-143 °C(lit.)
- storage temp.
- Inert atmosphere,2-8°C
- form
- Crystalline Needles or Powder
- color
- White to beige
- Water Solubility
- >=10 g/100 mL at 19 ºC
- Sensitive
- Hygroscopic
- BRN
- 3689156
- InChI
- InChI=1S/C6H6ClN.ClH/c7-4-6-2-1-3-8-5-6;/h1-3,5H,4H2;1H
- InChIKey
- UZGLOGCJCWBBIV-UHFFFAOYSA-N
- SMILES
- C1(CCl)C=NC=CC=1.Cl
- CAS DataBase Reference
- 6959-48-4(CAS DataBase Reference)
- EPA Substance Registry System
- 3-(Chloromethyl)pyridine hydrochloride (6959-48-4)
Safety
- Hazard Codes
- Xn,C,T
- Risk Statements
- 22-36/37/38-45-20/21/22-34
- Safety Statements
- 26-36-53-45-36/37/39
- RIDADR
- 2811
- WGK Germany
- 3
- RTECS
- US7000000
- F
- 3-10
- Hazard Note
- Corrosive
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29333999
- Hazardous Substances Data
- 6959-48-4(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H341Suspected of causing genetic defects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P43602
- Product name
- 3-(Chloromethyl)pyridine hydrochloride
- Purity
- 96%
- Packaging
- 5g
- Price
- $31.8
- Updated
- 2024/03/01
- Product number
- P43602
- Product name
- 3-(Chloromethyl)pyridine hydrochloride
- Purity
- 96%
- Packaging
- 25g
- Price
- $110
- Updated
- 2024/03/01
- Product number
- C0825
- Product name
- 3-(Chloromethyl)pyridine Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $64
- Updated
- 2024/03/01
- Product number
- C0825
- Product name
- 3-(Chloromethyl)pyridine Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 100g
- Price
- $255
- Updated
- 2024/03/01
- Product number
- A13279
- Product name
- 3-(Chloromethyl)pyridine hydrochloride, 97%
- Packaging
- 5g
- Price
- $26.65
- Updated
- 2024/03/01
3-Picolyl chloride hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White to pale brown solid
Uses
3-(Chloromethyl)pyridine Hydrochloride has been used as a reactant for the synthesis of (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-one derivatives as Polo-like kinase 4 (PLK4) inhibitors.
Application
3-Picolyl chloride hydrochloride is an organic synthetic reagent for the preparation of N,N-bis(pyridin-2-ylmethyl)aniline ligands, 2-oxodihydroquinoline-3-carboxamide derivatives, and 3β-amino-tropane arylamide derivatives with atypical antipsychotic profiles. It is also used in the preparation of novel bifunctional anion exchange resins for nuclear waste treatment.
General Description
Yellow powder or yellow-tan solid with an irritating odor.
Air & Water Reactions
Hygroscopic. Water soluble.
Reactivity Profile
3-Picolyl chloride hydrochloride is incompatible with strong oxidizing agents and strong bases.
Fire Hazard
Flash point data for 3-Picolyl chloride hydrochloride are not available; however, 3-Picolyl chloride hydrochloride is probably combustible.
Safety Profile
Suspected carcinogen with experimental carcinogenic data. Poison by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and Cl-.
Synthesis
Chloromethyl pyridine hydrochloride is the important industrial chemicals of various agricultural chemicals, medicine intermediate, Insecticides (tech) & Herbicides (tech), sterilant. A synthetic method of 3-(chloromethyl)pyridine hydrochloride (also known as 3-Picolyl chloride hydrochloride) comprises steps as follows: (1) 3-methylpyridine is taken as a raw material, water is taken as a solvent, and the 3-methylpyridine is oxidized into 3-picolinic acid with potassium permanganate, wherein the molar ratio of the 3-methylpyridine to the potassium permanganate is 1:(2.1-2.3), the oxidizing temperature is kept at 85-90 DEG C, heating is performed for 30 min, a reaction solution is adjusted to be acid after the reaction, and 3-picolinic acid is obtained after cooling and filtration; (2) the 3-picolinic acid and methanol react to produce methyl pyridine-3-carboxylate under the acid condition, and the molar ratio of the 3-picolinic acid to the methanol is 1:1.3; (3) the methyl pyridine-3-carboxylate is reduced to 3-pyridinemethanol; (4) the 3-pyridinemethanol reacts with thionyl chloride to produce a target product, namely, 3-(chloromethyl)pyridine hydrochloride, and the molar ratio of the 3-pyridinemethanol to the thionyl chloride is 1:(1.1-1.3).
3-Picolyl chloride hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Picolyl chloride hydrochloride manufacturers
- Product
- 3-Picolyl chloride hydrochloride 6959-48-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-09
- Product
- 3-Picolyl chloride hydrochloride 6959-48-4
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-12-02
- Product
- 3-Picolyl chloride hydrochloride 6959-48-4
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.9
- Supply Ability
- 1 ton
- Release date
- 2024-08-21