Dothiepin
- Product Name
- Dothiepin
- CAS No.
- 113-53-1
- Chemical Name
- Dothiepin
- Synonyms
- iz914;Dothep;IZ 914;dosulepin;Methiaden;DOTHIEPIN;Dosulepine;Prothiaden;Prothiadene;Dolsulepine
- CBNumber
- CB0378413
- Molecular Formula
- C19H21NS
- Formula Weight
- 295.44
- MOL File
- 113-53-1.mol
Dothiepin Property
- Melting point:
- 55-57°
- Boiling point:
- bp0.05 171-172°
- Density
- 1.1022 (rough estimate)
- refractive index
- 1.5300 (estimate)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Thick Oil to Low-Melting Solid
- pka
- 9.35±0.28(Predicted)
- color
- Off-White to Light Yellow
Safety
- RIDADR
- 3249
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 113-53-1(Hazardous Substances Data)
- Toxicity
- LD50 oral in rat: 450mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H361Suspected of damaging fertility or the unborn child
H362May cause harm to breast-fed children
- Precautionary statements
-
P201Obtain special instructions before use.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P263Avoid contact during pregnancy/while nursing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- Y0001965
- Product name
- Dosulepin for system suitability
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- Y0001965
- Price
- $147
- Updated
- 2023/01/07
- Product number
- D536500
- Product name
- Dothiepin
- Packaging
- 50mg
- Price
- $1355
- Updated
- 2021/12/16
- Product number
- API0007912
- Product name
- DOSULEPIN
- Purity
- 95.00%
- Packaging
- 2MG
- Price
- $300
- Updated
- 2021/12/16
- Product number
- 9808
- Product name
- Dothiepin
- Packaging
- 5mg
- Price
- $490
- Updated
- 2021/12/16
Dothiepin Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Low Melting Solid
History
Described in the 1960s by the Czech company Sdruzeni Podniku pro Zdravotnickon Vyrobu; SPOFA (Spofa, 1962)
Uses
A tricyclic antidepressant.
Definition
ChEBI: Dothiepin is a dibenzothiepine. It has a role as an antidepressant and an anticoronaviral agent.
Synthesis Reference(s)
Synthesis (Spofa, 1962): S-Benzylthiosalicylic acid is treated with polyphosphoric acid and the resulting cyclic ketone is reacted with 3-dimethylaminopropyl magnesium chloride to afford an alcohol which is dehydrated with sulfuric acid.
Synthesis of dosulepin
Clinical Use
Dosulepin (also referred to as dothiepin) is a member of the TCA family and has similar clinical uses as amitrip- tyline, thus providing effective treatment of depression (Goldstein and Claghorn, 1980; Lancaster and Gonzales, 1989; Donovan et al., 1991) and also against pain (Feinmann et al., 1984; Caruso et al., 1987) and tinnitus. Like amitriptyline it has sedative properties, however its anti-muscarinic side-effects are less pronounced. Dosulepin is readily absorbed from the GI tract and extensively demethylated while undergoing a first-pass effect. Metabolic pathways include next to hydroxylation and N-oxidation steps, S-oxidation. Elimination half-lifes vary from 14 to 24 hours interindividually (Maguire et al., 1982; Yu et al., 1986; Ilett et al., 1993).
Dothiepin Preparation Products And Raw materials
Raw materials
Preparation Products
Dothiepin Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71