Dothiepin

Product Name: Dothiepin
CAS No.: 113-53-1
Chemical Name: Dothiepin
Synonyms: iz914;Dothep;IZ 914;dosulepin;Methiaden;DOTHIEPIN;Dosulepine;Prothiaden;Prothiadene;Dolsulepine
CBNumber: CB0378413
Molecular Formula: C19H21NS
Formula Weight: 295.44
MOL File: 113-53-1.mol

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Dothiepin Property

Melting point:: 55-57°
Boiling point:: bp0.05 171-172°
Density: 1.1022 (rough estimate)
refractive index: 1.5300 (estimate)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Thick Oil to Low-Melting Solid
pka: 9.35±0.28(Predicted)
color: Off-White to Light Yellow

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Safety

RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 113-53-1(Hazardous Substances Data)
Toxicity: LD50 oral in rat: 450mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

H362May cause harm to breast-fed children

Precautionary statements

P201Obtain special instructions before use.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001965
Product name: Dosulepin for system suitability
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: Y0001965
Price: $147
Updated: 2023/01/07

TRC

Product number: D536500
Product name: Dothiepin
Packaging: 50mg
Price: $1355
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007912
Product name: DOSULEPIN
Purity: 95.00%
Packaging: 2MG
Price: $300
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 9808
Product name: Dothiepin
Packaging: 5mg
Price: $490
Updated: 2021/12/16

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Dothiepin Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Low Melting Solid

History

Described in the 1960s by the Czech company Sdruzeni Podniku pro Zdravotnickon Vyrobu; SPOFA (Spofa, 1962)

Uses

A tricyclic antidepressant.

Definition

ChEBI: Dothiepin is a dibenzothiepine. It has a role as an antidepressant and an anticoronaviral agent.

Synthesis Reference(s)

Synthesis (Spofa, 1962): S-Benzylthiosalicylic acid is treated with polyphosphoric acid and the resulting cyclic ketone is reacted with 3-dimethylaminopropyl magnesium chloride to afford an alcohol which is dehydrated with sulfuric acid.

Synthesis of dosulepin

Clinical Use

Dosulepin (also referred to as dothiepin) is a member of the TCA family and has similar clinical uses as amitrip- tyline, thus providing effective treatment of depression (Goldstein and Claghorn, 1980; Lancaster and Gonzales, 1989; Donovan et al., 1991) and also against pain (Feinmann et al., 1984; Caruso et al., 1987) and tinnitus. Like amitriptyline it has sedative properties, however its anti-muscarinic side-effects are less pronounced. Dosulepin is readily absorbed from the GI tract and extensively demethylated while undergoing a first-pass effect. Metabolic pathways include next to hydroxylation and N-oxidation steps, S-oxidation. Elimination half-lifes vary from 14 to 24 hours interindividually (Maguire et al., 1982; Yu et al., 1986; Ilett et al., 1993).

Dothiepin Preparation Products And Raw materials

Raw materials

Preparation Products

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Dothiepin Suppliers

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113-53-1, DothiepinRelated Search:

Citalopram Trazodone CIS,TRANS-DOTHIEPIN-D3,100/MLINMETHANOL dothiepin sulfoxide,Dothiepin S-oxide DOTHIEPIN HYDROCHLORIDE,DOTHIEPIN HCL,Dothiepin·hydrochloric acid,DOSULEPIN HYDROCHLORIDE (DOTHIEPIN HYDROCHLORIDE) DOSULEPIN (DOTHIEPIN) HYDROCHLORIDE DOTHIEPIN-D3 11-(1-Methyl-4-piperidylidene)-6,11-dihydrodibenzo(b,e)thiepine-9-carb oxylic acid HCl (E)-9-Fluoro-11-(3-dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)t hiepin hydrogen maleate Dothiepin 3-dibenzo[b,e]thiepin-11(6H)-ylidene-8-methyl-8-azabicyclo[3.2.1]octane hydrochloride Tropatepine

(3E)-3-Dibenzo[b,E]thiepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepin

1-Propanamine, 3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-

3-Dibenzo(b,e)thiepin-11(6H)-ylidene-N,N-dimethyl-1-propamine

3-dibenzo(b,e)thiepin-11(6h)-ylidene-n,n-dimethyl-1-propanamin

3-Dibenzo[b,e]thiepin-11(6H)-ylidine-N,N-dimethyl-propanamine

Dibenzo[b,e]thiepin, 1-propanamine deriv.

Dibenzo[b,e]thiepin-delta11(6H),gamma-propylamine, N,N-dimethyl-

dosulepin

Dosulepine

Dothep

IZ 914

iz914

n,n-dimethyl-3-(dibenzo(b,e)thiepin-delta-sup(11(6h),gamma))-propylamin

N,N-Dimethyldibenzo(b,e)thiepin-delta-sup(11(6H),gamma)propylamine

Propylamine, N,N-dimethyl-3-(dibenzo(b,e)thiepin-delta-sup(11(6H),gamma))-

Prothiaden

Prothiaden spofa

Prothiadene

3-DIBENZO[B,E] THIEPIN-11-(6H)-YLIDENE-N,N-DIMETHYL-PROPONAMINE

(E)-3-[Dibenzo[b,e]thiepin-11(6H)-ylidene]-N,N-dimethyl-1-propanamine

(E)-3-[Dibenzo[b,e]thiepin-11(6H)-ylidene]-N,N-dimethylpropane-1-amine

Dothiepin (cis/trans)

3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-diMethyl-

DOTHIEPIN,3-DIBENZO[B,E] THIEPIN-11-(6H)-YLIDENE-N,N-DIMETHYL-PROPONAMINE

Dolsulepine

Methiaden

CIS,TRANS-DOTHIEPIN,1.0MG/MLINMETHANOL

3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine

N,N-Dimethyl- dibenzo[b,e]thiepin-11(6H),-propylamine

DOTHIEPIN

3-(6,11-dihydrodibenzo(b,e)thiepin-11-ylidene)propyldimethylamine

Dothiepin-d3 Maleate

113-53-1

Chemical Amines

Amines

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds