(R)-2-(+)-AMINO-1,1,2-TRIPHENYLETHANOL
- Product Name
- (R)-2-(+)-AMINO-1,1,2-TRIPHENYLETHANOL
- CAS No.
- 79868-79-4
- Chemical Name
- (R)-2-(+)-AMINO-1,1,2-TRIPHENYLETHANOL
- Synonyms
- (R)-1,1,2-Triphenyl-2-aminoethanol;(2R)-1,1,2-Triphenyl-2-aminoethanol;(R)-2-(+)-AMINO-1,1,2-TRIPHENYLETHANOL;R-N-Boc-2-Amino-1,1-diphenyl-1-propanol;(S)-2-Amino-1,1-diphenyl-1-propanol,99%e.e.;Benzeneethanol, β-amino-α,α-diphenyl-, (βR)-;Benzeneethanol, b-amino-a,a-diphenyl-, (bR)-;(R)-2-(+)-AMINO-1,1,2-TRIPHENYLETHANOL USP/EP/BP;(R)-2-Amino-1,1,2-triphenylethanol(R)-2-Amino-1,1,2-triphenylethanol
- CBNumber
- CB0379142
- Molecular Formula
- C20H19NO
- Formula Weight
- 289.37
- MOL File
- 79868-79-4.mol
(R)-2-(+)-AMINO-1,1,2-TRIPHENYLETHANOL Property
- Melting point:
- 130-131℃
- Boiling point:
- 456.0±40.0 °C(Predicted)
- Density
- 1.162±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 10.89±0.50(Predicted)
Safety
- HS Code
- 2922190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 4656-1-RJ
- Product name
- (R)-2-(+)-Amino-1,1,2-triphenylethanol
- Packaging
- 100mg
- Price
- $184
- Updated
- 2021/12/16
- Product number
- FA140896
- Product name
- (R)-2-Amino-1,1,2-triphenylethanol
- Packaging
- 250mg
- Price
- $245
- Updated
- 2021/12/16
- Product number
- 4656-1-RJ
- Product name
- (R)-2-(+)-Amino-1,1,2-triphenylethanol
- Packaging
- 250mg
- Price
- $314
- Updated
- 2021/12/16
- Product number
- CCH0013249
- Product name
- (R)-2-(+)-AMINO-1,1,2-TRIPHENYLETHANOL
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $396.9
- Updated
- 2021/12/16
- Product number
- FA140896
- Product name
- (R)-2-Amino-1,1,2-triphenylethanol
- Packaging
- 500mg
- Price
- $430
- Updated
- 2021/12/16
(R)-2-(+)-AMINO-1,1,2-TRIPHENYLETHANOL Chemical Properties,Usage,Production
Synthesis
1395342-04-7
60539-17-5
Amino alcohol (S,R)-3n (64 mg, 0.15 mmol) was used as a raw material, and Pd(OH)2 (16 mg, 0.023 mmol, 20% Pd (dry basis) loaded on carbon, containing ~50% water) was mixed in a solvent mixture of acetic acid/ dichloromethane/ methanol (0.15 mL/0.45 mL/1.5 mL) under hydrogen atmosphere (1 atm) at 30 °C with stirring overnight. Upon completion of the reaction, 1.0 M NaOH solution was added to the reaction mixture, at which time a white solid precipitated. The solid was removed by filtration and the filtrate was extracted with dichloromethane. The combined organic phases were washed sequentially with water, brine and dried with anhydrous Na2SO4. The solvent was removed by concentration under reduced pressure and the residue was purified by silica gel column chromatography (eluent: methanol/dichloromethane = 1/50) to afford amino alcohol (R)-4 as a white solid (28 mg, 66% yield). The enantiomeric excess (ee) of the product was 100%. Specific optical rotation [α]D20 was +246.4 (c 1.0, CHCl3).1H NMR (400 MHz, CDCl3) δ 1.60 (broad peak, 2H), 4.68 (broad peak, 1H), 5.00 (single peak, 1H), 6.99-7.05 (multiple peaks, 3H), 7.10-7.13 (multiple peaks, 7H), 7.27 (triple peak) J=7.2 Hz, 1H), 7.39 (triple peaks, J=8.0 Hz, 2H), 7.74 (double peaks, J=7.6 Hz, 2H); 13C NMR (100 MHz, CDCl3) δ 61.72, 79.51, 125.98, 126.19, 126.50, 126.98, 127.19, 127.32 123.39, 128.50, 128.62, 140.02, 143.83, 146.46. The spectral data were in agreement with those reported in the literature. HPLC analysis (chiral column Chiralpak OD-H, mobile phase: hexane/isopropanol = 90/10, flow rate = 1.0 mL/min, detection wavelength λ = 214 nm): retention time of main peak tmajor=16.31 min.
References
[1] Tetrahedron Letters, 2012, vol. 53, # 38, p. 5084 - 5087
(R)-2-(+)-AMINO-1,1,2-TRIPHENYLETHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-2-(+)-AMINO-1,1,2-TRIPHENYLETHANOL manufacturers
- Product
- (R)-2-(+)-AMINO-1,1,2-TRIPHENYLETHANOL 79868-79-4
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2020-01-09