ChemicalBook > CAS DataBase List > 3-Bromopyruvic acid

3-Bromopyruvic acid

Product Name
3-Bromopyruvic acid
CAS No.
1113-59-3
Chemical Name
3-Bromopyruvic acid
Synonyms
3-bromopyruvate;3-BROMOPYRUVIC ACID;3-BROMO-2-OXOPROPANOIC ACID;bromopyruvate;BROMOPYRUVIC ACID;3-BROMO-2-OXOPROPIONIC ACID;2-Oxo-3-bromopropanoic acid;beta-bromopyruvicacid;NSC 11731;NSC 62343
CBNumber
CB0380692
Molecular Formula
C3H3BrO3
Formula Weight
166.96
MOL File
1113-59-3.mol
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3-Bromopyruvic acid Property

Melting point:
77-82 °C
Boiling point:
223.4±23.0 °C(Predicted)
Density 
1.7314 (rough estimate)
refractive index 
1.4650 (estimate)
storage temp. 
2-8°C
solubility 
water: soluble1g/10 mL, clear, colorless
form 
White crystalline solid
pka
1.84±0.54(Predicted)
color 
White to Almost white
Water Solubility 
Soluble in water, dimethyl sulfoxide, ethyl acetate and water.
BRN 
1746786
InChIKey
PRRZDZJYSJLDBS-UHFFFAOYSA-N
CAS DataBase Reference
1113-59-3(CAS DataBase Reference)
EPA Substance Registry System
Propanoic acid, 3-bromo-2-oxo- (1113-59-3)
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Safety

Hazard Codes 
C
Risk Statements 
34-20/21/22
Safety Statements 
26-36/37/39-45-27
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
RTECS 
UZ0840000
19-21
Hazard Note 
Corrosive
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29183000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
16490
Product name
Bromopyruvic acid
Purity
≥98.0%
Packaging
10g
Price
$112
Updated
2024/03/01
Sigma-Aldrich
Product number
16490
Product name
Bromopyruvic acid
Purity
≥98.0%
Packaging
50g
Price
$399
Updated
2024/03/01
TCI Chemical
Product number
B1153
Product name
3-Bromopyruvic Acid
Purity
>98.0%(T)
Packaging
5g
Price
$96
Updated
2024/03/01
TCI Chemical
Product number
B1153
Product name
3-Bromopyruvic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$319
Updated
2024/03/01
Alfa Aesar
Product number
L00720
Product name
Bromopyruvic acid, 97%
Packaging
2g
Price
$39.2
Updated
2024/03/01
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3-Bromopyruvic acid Chemical Properties,Usage,Production

Chemical Properties

Off-white solid

Uses

Bromopyruvic Acid is a synthetic brominated derivative of pyruvic acid. Bromopyruvic Acid maybe a potential treatment for certain types of cancer as it has shown to be effective at eliminating aggress ive liver tumors.

Uses

Bromopyruvic acid is used as an affinity label for cysteine residues and a potential anti-cancer agent. It is involved in the synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids and substituted pyranones. It plays a vital role as a cross-linker between nucleic acids and proteins. It is used as an anticancer agent for lung tumors.

Uses

3-Bromopyruvic acid is an intermediate of the fungicide thiabendazole. It was also used in the synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids.

Preparation

Synthesis method of 3-bromopyruvic acid: add a little concentrated sulfuric acid and solvent dichloromethane to pyruvic acid in a reaction flask, add bromine dropwise for about 3.5h and stir, a white precipitate is produced, then continue to stir for 1h, dilute with cyclohexane and petroleum ether, then cool the reaction mixture to get crystals, filter, wash with petroleum ether and dry to get the finished product of 3-bromopyruvic acid.

Definition

ChEBI: 3-bromopyruvic acid is a 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is replaced by bromine. Synthetic brominated derivative and structural analog of pyruvic acid. Highly reactive alkylating agent. Anti-cancer drug It has a role as an alkylating agent and an antineoplastic agent. It is a 2-oxo monocarboxylic acid and an organobromine compound. It derives from a pyruvic acid. It is a conjugate acid of a 3-bromopyruvate.

General Description

Bromopyruvic acid is an affinity label for cysteine residues?. It acts as cross-linker between nucleic acids and proteins. Kinetics of inactivation of pancreatic ribonuclease A by bromopyruvic acid has been investigated.

storage

Store at -20°C

Purification Methods

Dry it by azeotropic distillation (with toluene), and then recrystallise it from dry CHCl3. Dry for 48hours at 20o (0.5 torr) over P2O5. Store it at 0o. [Labandiniere et al. J Org Chem 52 157 1987, Beilstein 3 III 1167.]

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View Lastest Price from 3-Bromopyruvic acid manufacturers

Shandong Deshang Chemical Co., Ltd.
Product
3-Bromopyruvic acid 1113-59-3
Price
US $8.90-5.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 tons
Release date
2024-06-26
Hebei Weibang Biotechnology Co., Ltd
Product
3-Bromopyruvic acid 1113-59-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-29
Hebei Mojin Biotechnology Co.,Ltd
Product
Bromopyruvic acid 1113-59-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-09-24

1113-59-3, 3-Bromopyruvic acidRelated Search:


  • BROMOPYRUVIC ACID
  • 3-BROMOPYRUVIC ACID
  • 3-BROMO-2-OXOPROPANOIC ACID
  • 3-BROMO-2-OXOPROPIONIC ACID
  • 3-Bromopyruvic acid ,97%
  • 2-Oxo-3-bromopropanoic acid
  • 2-Oxo-3-bromopropionic acid
  • beta-bromopyruvicacid
  • bromopyruvate
  • Hexokinase II Inhibitor II, 3-BP
  • 3-bromo-2-oxo-propanoicaci
  • 3-bromopyruvate
  • Bromopyruvic acid, 3-Bromo-2-oxopropionic acid
  • NSC 11731
  • NSC 62343
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  • BroMopyruvic acid >=97.0% (T)
  • 3-bromo-2-keto-propionic acid
  • 3-Bromopyruvic acid (Bromopyruvic acid
  • Hexokinase II Inhibitor II, 3-BP - CAS 1113-59-3 - Calbiochem
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  • 4-Amino-5-(aminocarbonyl)imidazole H
  • 3-Bromopyruvic acid (3-BP)
  • Hexokinase II Inhibitor II
  • 3-Brom-2-oxopropionsure
  • 3-Bromopyruvic Acid &gt
  • Bromopyruvic acid,98%
  • Bromopyruvic acid (3-bromopyruvic acid)
  • 3-Bromopyruvic Acid, ≥ 98.0%
  • 1113-59-3
  • BrCH2COCOOH
  • C3H3BrO3
  • C3H3O3Br
  • Building Blocks
  • Carboxylic Acids
  • Carbonyl Compounds
  • C1 to C5
  • Organic Building Blocks
  • Aliphatics
  • Carboxylic Acids
  • Organic acids
  • Carboxylic Acids
  • Piperidines