3-Bromopyruvic acid
- Product Name
- 3-Bromopyruvic acid
- CAS No.
- 1113-59-3
- Chemical Name
- 3-Bromopyruvic acid
- Synonyms
- 3-bromopyruvate;3-BROMOPYRUVIC ACID;3-BROMO-2-OXOPROPANOIC ACID;bromopyruvate;BROMOPYRUVIC ACID;3-BROMO-2-OXOPROPIONIC ACID;2-Oxo-3-bromopropanoic acid;beta-bromopyruvicacid;NSC 11731;NSC 62343
- CBNumber
- CB0380692
- Molecular Formula
- C3H3BrO3
- Formula Weight
- 166.96
- MOL File
- 1113-59-3.mol
3-Bromopyruvic acid Property
- Melting point:
- 77-82 °C
- Boiling point:
- 223.4±23.0 °C(Predicted)
- Density
- 1.7314 (rough estimate)
- refractive index
- 1.4650 (estimate)
- storage temp.
- 2-8°C
- solubility
- water: soluble1g/10 mL, clear, colorless
- form
- White crystalline solid
- pka
- 1.84±0.54(Predicted)
- color
- White to Almost white
- Water Solubility
- Soluble in water, dimethyl sulfoxide, ethyl acetate and water.
- BRN
- 1746786
- InChIKey
- PRRZDZJYSJLDBS-UHFFFAOYSA-N
- CAS DataBase Reference
- 1113-59-3(CAS DataBase Reference)
- EPA Substance Registry System
- Propanoic acid, 3-bromo-2-oxo- (1113-59-3)
Safety
- Hazard Codes
- C
- Risk Statements
- 34-20/21/22
- Safety Statements
- 26-36/37/39-45-27
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- RTECS
- UZ0840000
- F
- 19-21
- Hazard Note
- Corrosive
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29183000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 16490
- Product name
- Bromopyruvic acid
- Purity
- ≥98.0%
- Packaging
- 10g
- Price
- $112
- Updated
- 2024/03/01
- Product number
- 16490
- Product name
- Bromopyruvic acid
- Purity
- ≥98.0%
- Packaging
- 50g
- Price
- $399
- Updated
- 2024/03/01
- Product number
- B1153
- Product name
- 3-Bromopyruvic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $96
- Updated
- 2024/03/01
- Product number
- B1153
- Product name
- 3-Bromopyruvic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $319
- Updated
- 2024/03/01
- Product number
- L00720
- Product name
- Bromopyruvic acid, 97%
- Packaging
- 2g
- Price
- $39.2
- Updated
- 2024/03/01
3-Bromopyruvic acid Chemical Properties,Usage,Production
Chemical Properties
Off-white solid
Uses
Bromopyruvic Acid is a synthetic brominated derivative of pyruvic acid. Bromopyruvic Acid maybe a potential treatment for certain types of cancer as it has shown to be effective at eliminating aggress ive liver tumors.
Uses
Bromopyruvic acid is used as an affinity label for cysteine residues and a potential anti-cancer agent. It is involved in the synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids and substituted pyranones. It plays a vital role as a cross-linker between nucleic acids and proteins. It is used as an anticancer agent for lung tumors.
Uses
3-Bromopyruvic acid is an intermediate of the fungicide thiabendazole. It was also used in the synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids.
Preparation
Synthesis method of 3-bromopyruvic acid: add a little concentrated sulfuric acid and solvent dichloromethane to pyruvic acid in a reaction flask, add bromine dropwise for about 3.5h and stir, a white precipitate is produced, then continue to stir for 1h, dilute with cyclohexane and petroleum ether, then cool the reaction mixture to get crystals, filter, wash with petroleum ether and dry to get the finished product of 3-bromopyruvic acid.
Definition
ChEBI: 3-bromopyruvic acid is a 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is replaced by bromine. Synthetic brominated derivative and structural analog of pyruvic acid. Highly reactive alkylating agent. Anti-cancer drug It has a role as an alkylating agent and an antineoplastic agent. It is a 2-oxo monocarboxylic acid and an organobromine compound. It derives from a pyruvic acid. It is a conjugate acid of a 3-bromopyruvate.
General Description
Bromopyruvic acid is an affinity label for cysteine residues?. It acts as cross-linker between nucleic acids and proteins. Kinetics of inactivation of pancreatic ribonuclease A by bromopyruvic acid has been investigated.
storage
Store at -20°C
Purification Methods
Dry it by azeotropic distillation (with toluene), and then recrystallise it from dry CHCl3. Dry for 48hours at 20o (0.5 torr) over P2O5. Store it at 0o. [Labandiniere et al. J Org Chem 52 157 1987, Beilstein 3 III 1167.]
3-Bromopyruvic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Bromopyruvic acid manufacturers
- Product
- Bromopyruvic acid 1113-59-3
- Price
- US $20.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 Ton
- Release date
- 2023-03-02
- Product
- 3-Bromopyruvic acid 1113-59-3
- Price
- US $80.00-800.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-13
- Product
- 3-Bromopyruvic acid 1113-59-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2022-10-24