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ISOXAFLUTOLE

Product Name
ISOXAFLUTOLE
CAS No.
141112-29-0
Chemical Name
ISOXAFLUTOLE
Synonyms
MERLIN;BALANCE;Ift cpd;Hsdb 7275;Isoxautole;Exp 31130a;SOXAFLUTOLE;ISOXAFLUTOLE;Isoxaflutole 0;Isoxaflutole [iso]
CBNumber
CB0382227
Molecular Formula
C15H12F3NO4S
Formula Weight
359.32
MOL File
141112-29-0.mol
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ISOXAFLUTOLE Property

Melting point:
138-138.5° (Cain); mp 140°
Boiling point:
575.1±50.0 °C(Predicted)
Density 
1.59
Flash point:
>130 °C
storage temp. 
Sealed in dry,2-8°C
solubility 
Chloroform, DCM, Ethyl Acetate, Methanol
pka
-4.29±0.50(Predicted)
color 
White
BRN 
8344543
LogP
2.320
CAS DataBase Reference
141112-29-0
EPA Substance Registry System
Isoxaflutole (141112-29-0)
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Safety

Hazard Codes 
Xn,N
Risk Statements 
50/53-63
Safety Statements 
36/37-60-61
RIDADR 
UN3077 9/PG 3
WGK Germany 
3
Hazardous Substances Data
141112-29-0(Hazardous Substances Data)
Toxicity
LD50 in rats, quails, mallard ducks (mg/kg): >5000, >2150, >2150 orally; in rabbits (mg/kg): >2000 dermally (Luscombe)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
46437
Product name
Isoxaflutole
Purity
PESTANAL?, analytical standard
Packaging
100mg
Price
$147
Updated
2024/03/01
TRC
Product number
I918140
Product name
Isoxaflutole
Packaging
10mg
Price
$580
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
71008
Product name
Isoxaflutole
Packaging
2.5mg
Price
$675
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
AGR0000257
Product name
ISOXAFLUTOLE
Purity
95.00%
Packaging
5MG
Price
$496
Updated
2021/12/16
Crysdot
Product number
CD11263309
Product name
(5-Cyclopropylisoxazol-4-yl)(2-(methylsulfonyl)-4-(trifluoromethyl)phenyl)methanone
Purity
95+%
Packaging
1g
Price
$89
Updated
2021/12/16
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ISOXAFLUTOLE Chemical Properties,Usage,Production

Description

Isoxaflutole is a 4-benzoyl isoxazole molecule and is used as a pre- and early post-emergence herbicide for the control of a wide range of important broadleaf and grass weeds in maize (Zea mays), both in Europe and in North America. It is also registered for use in sugarcane in Central and South America (2–4). It causes characteristic bleaching of newly developed tissues of susceptible species followed by growth cessation and necrosis. Marketed as Balance for corn (maize) in the United States, and Merlin for corn in Europe; and in sugarcane, it mixes well with metolachlor, acetochlor, dimethenamid, and atrazine to complete the weed spectrum and to reduce the application rates of the latter compounds (2). Isoxaflutole also controls triazineresistant weeds in the field (4).

Uses

Isoxaflutole is an pesticide used to selectively control both grass and broad-leaved weeds in maize and sugar cane. Isoxaflutole is known to work by inhibiting the enzyme 4-Hydroxyphenylpyruvate dioxygenase (HPPD) which results in the disruption of pigment biosynthesis.

Uses

Herbicide.

Definition

ChEBI: Isoxaflutole is a member of the class of isoxazoles that is 1,2-oxazole substituted by a 2-(methanesulfonyl)-4-(trifluoromethyl)benzoyl group and a cyclopropyl group at positions 4 and 5, respectively. It is a 4-hydroxyphenylpyruvate dioxygenase inhibitor which is used as a herbicide for weed control in maize and sugarcane. It has a role as an EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor, a proherbicide and an agrochemical. It is a member of cyclopropanes, a member of isoxazoles, an aromatic ketone, a member of (trifluoromethyl)benzenes and a sulfone.

Pharmacology

Isoxaflutole is readily taken up by roots and foliar tissues and then rapidly degraded to a diketonitrile derivative (2-cyclopropyl-3-(2-mesyl-4-trifluoromethylphenyl)- 3-oxo propanenitrile) , which is translocated throughout the plant via xylem and phloem (2,3,6,8). It is this metabolite that inhibits HPPD (7), thereby depleting the plastoquinone pools in developing leaves. Plastoquinone is a cofactor in the desaturation of phytoene, levels of which increase in bleached leaves, concomitant with decreases in colored carotenoids (6). Although bleaching is the primary symptom associated with HPPD inhibition, subsequent growth suppression and necrosis are also believed to be a consequence (8).
Isoxaflutole also degrades to the diketonitrile derivative in the soil (3,8). The half-life of isoxaflutole in soil is dependent on soil type, pH, and moisture, ranging from 12 hours to 3 days under laboratory conditions (8). The physicochemical properties of isoxaflutole and of diketonitrile play an important role in both soil and herbicidal activity and selectivity (8).

ISOXAFLUTOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ISOXAFLUTOLE manufacturers

Career Henan Chemical Co
Product
ISOXAFLUTOLE 141112-29-0
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-23

141112-29-0, ISOXAFLUTOLERelated Search:


  • MERLIN
  • BALANCE
  • ISOXAFLUTOLE
  • ISOXAFLUTOLE 45% SOLUTION
  • 5-cyclopropyl-4-[2-(methylsulfonyl)-4-(trifluoromethyl)benzoyl]isoxazole
  • isoxaflutole (bsi, pa iso)
  • isoxaflutole (ISO) 5-cyclopropyl-1,2-oxazol-4-yl α,α,α-trifluoro-2-mesyl-p-tolyl ketone
  • Isoxaflutole 0
  • Isoxautole
  • (5-Cyclopropyl-4-isoxazolyl)[2-(methylsulfonyl)-4-(trifluoromethyl)phenyl]methanone
  • Einecs annex I index 606-054-00-7
  • Exp 31130a
  • Hsdb 7275
  • Ift cpd
  • Isoxaflutole [iso]
  • Isoxaflutole 100mg [141112-29-0]
  • (5-Cyclopropylisoxazol-4-yl)(2-(methylsulfonyl)-4-(trifluoromethyl)phenyl)methanone
  • Isoxaflutole 97% TC
  • Isoxaflutole pesticide
  • Isoxautole Solution,100ppm
  • SOXAFLUTOLE
  • Isoxaflutole@100 μg/mL in AcCN
  • Methanone, (5-cyclopropyl-4-isoxazolyl)[2-(methylsulfonyl)-4-(trifluoromethyl)phenyl]-
  • 5-cyclopropyl-4-[2-methanesulfonyl-4-(trifluorome thyl)benzoyl]-1,2-oxazole
  • Isoxaflutole Solution in Acetonitrile, 1000μg/mL
  • Isoxaflutole Solution in Methanol
  • Isoxaflutole Solution in Acetonitrile
  • 141112-29-0