BETA-AMANITIN

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Acute toxicity

Product Name: BETA-AMANITIN
CAS No.: 21150-22-1
Chemical Name: BETA-AMANITIN
Synonyms: b-Amanitin;β-Amanitin;B-Amanitine;β-Amanitine;BETA-AMANITIN;beta-amatoxin;beta-Amanitine;β-Amanitin DISCONTINUED;1-l-asparticacid-alpha-amaniti;α-Amanitin, 1-L-aspartic acid-
CBNumber: CB0383204
Molecular Formula: C39H53N9O15S
Formula Weight: 919.95
MOL File: 21150-22-1.mol

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BETA-AMANITIN Property

Melting point:: 300°
Boiling point:: 1599.6±65.0 °C(Predicted)
Density: 1.1725 (rough estimate)
refractive index: 1.7400 (estimate)
storage temp.: −20°C
solubility: Water: 1 mg/ml
pka: 4.02±0.10(Predicted)
form: White to off-white powder.
color: White to off-white

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Safety

Hazard Codes: T+
Risk Statements: 26/27/28
Safety Statements: 7-28-36/37/39-45
RIDADR: UN 3462 6.1/PG 1
WGK Germany: 3
RTECS: NJ8324000
HazardClass: 6.1(a)
PackingGroup: I
HS Code: 2934999090
Toxicity: LD50 i.p. in albino mice: 0.4 mg/kg (Wieland, Wieland)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A1304
Product name: β-Amanitin from Amanita phalloides
Purity: ~90% (HPLC)
Packaging: 1mg
Price: $865
Updated: 2024/03/01

Cayman Chemical

Product number: 18142
Product name: β-Amanitin
Purity: ≥95%
Packaging: 1mg
Price: $241
Updated: 2024/03/01

Biosynth Carbosynth

Product number: FA57612
Product name: b-Amanitin
Packaging: 1mg
Price: $300
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA57612
Product name: b-Amanitin
Packaging: 2mg
Price: $400
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA57612
Product name: b-Amanitin
Packaging: 5mg
Price: $600
Updated: 2021/12/16

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BETA-AMANITIN Chemical Properties,Usage,Production

Acute toxicity

peritoneal-mouse LD50: 0.4 mg/kg; unnamed-mouse LD50: 0.4 mg/kg

Mechanism of action

β-Amanitin is a cyclic peptide found in several species of the Amanita genus, as well as other poisonous fungi. It inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase, thus preventing mammalian protein synthesis. The biological activity of this toxin is similar to that of α-amanitin but differs structurally by the presence of a carboxyl group, which is useful for coupling reactions.

Uses

β-Amanitin from Amanita phalloides has been used:

as a calibration standard for the quantification of β-Amanitin using liquid chromatography-high resolution-mass spectrometry/mass spectrometry (LC-HR-MS/MS) method.
to determine its concentration in urine samples by capillary zone electrophoresis (CZE).
in the analysis of β-amanitin in toxic mushrooms by liquid chromatography coupled to time-of-flight mass spectrometry.

Uses

As a tool in molecular biology.

General Description

β-Amanitin belongs to the family of amatoxins. Amanitins are made of bicyclic octapeptides. β-Amanitin is composed of a carboxyl group and is acidic in nature.

Biochem/physiol Actions

Toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but not RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.

BETA-AMANITIN Preparation Products And Raw materials

Raw materials

Preparation Products

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21150-22-1, BETA-AMANITINRelated Search:

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beta-Amanitine

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b-Amanitin

beta-Amanitin from Amanita Phalloides

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β-Amanitin

β-Amanitin DISCONTINUED

β-Amanitine

β-Amanitin from Amanita phalloides

21150-22-1

C39H53N9O15S

DNA-RNA Transcription Regulators

Gene Regulation and Expression

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Cell Signaling and Neuroscience

DNA-RNA Transcription RegulatorsCell Signaling and Neuroscience

Gene Regulation and Expression

Mushroom

Toxins and Venoms