BETA-AMANITIN
Acute toxicity- Product Name
- BETA-AMANITIN
- CAS No.
- 21150-22-1
- Chemical Name
- BETA-AMANITIN
- Synonyms
- b-Amanitin;β-Amanitin;B-Amanitine;β-Amanitine;BETA-AMANITIN;beta-amatoxin;beta-Amanitine;β-Amanitin DISCONTINUED;1-l-asparticacid-alpha-amaniti;α-Amanitin, 1-L-aspartic acid-
- CBNumber
- CB0383204
- Molecular Formula
- C39H53N9O15S
- Formula Weight
- 919.95
- MOL File
- 21150-22-1.mol
BETA-AMANITIN Property
- Melting point:
- 300°
- Boiling point:
- 1599.6±65.0 °C(Predicted)
- Density
- 1.1725 (rough estimate)
- refractive index
- 1.7400 (estimate)
- storage temp.
- −20°C
- solubility
- Water: 1 mg/ml
- pka
- 4.02±0.10(Predicted)
- form
- White to off-white powder.
Safety
- Hazard Codes
- T+
- Risk Statements
- 26/27/28
- Safety Statements
- 7-28-36/37/39-45
- RIDADR
- UN 3462 6.1/PG 1
- WGK Germany
- 3
- RTECS
- NJ8324000
- HazardClass
- 6.1(a)
- PackingGroup
- I
- HS Code
- 2934999090
- Toxicity
- LD50 i.p. in albino mice: 0.4 mg/kg (Wieland, Wieland)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- A1304
- Product name
- β-Amanitin from Amanita phalloides
- Purity
- ~90% (HPLC)
- Packaging
- 1mg
- Price
- $865
- Updated
- 2024/03/01
- Product number
- 18142
- Product name
- β-Amanitin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $241
- Updated
- 2024/03/01
- Product number
- FA57612
- Product name
- b-Amanitin
- Packaging
- 1mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FA57612
- Product name
- b-Amanitin
- Packaging
- 2mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- FA57612
- Product name
- b-Amanitin
- Packaging
- 5mg
- Price
- $600
- Updated
- 2021/12/16
BETA-AMANITIN Chemical Properties,Usage,Production
Acute toxicity
peritoneal-mouse LD50: 0.4 mg/kg; unnamed-mouse LD50: 0.4 mg/kg
Mechanism of action
β-Amanitin is a cyclic peptide found in several species of the Amanita genus, as well as other poisonous fungi. It inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase, thus preventing mammalian protein synthesis. The biological activity of this toxin is similar to that of α-amanitin but differs structurally by the presence of a carboxyl group, which is useful for coupling reactions.
Uses
β-Amanitin from Amanita phalloides has been used:
- as a calibration standard for the quantification of β-Amanitin using liquid chromatography-high resolution-mass spectrometry/mass spectrometry (LC-HR-MS/MS) method.
- to determine its concentration in urine samples by capillary zone electrophoresis (CZE).
- in the analysis of β-amanitin in toxic mushrooms by liquid chromatography coupled to time-of-flight mass spectrometry.
Uses
As a tool in molecular biology.
General Description
β-Amanitin belongs to the family of amatoxins. Amanitins are made of bicyclic octapeptides. β-Amanitin is composed of a carboxyl group and is acidic in nature.
Biochem/physiol Actions
Toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but not RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.