2,4-Difluorophenylboronic acid
- Product Name
- 2,4-Difluorophenylboronic acid
- CAS No.
- 144025-03-6
- Chemical Name
- 2,4-Difluorophenylboronic acid
- Synonyms
- Difluorophenylboronic acid;B-(2,4-Difluorophenyl)boronic acid;AKOS BRN-0089;CAS:144025-03-6;2,4-difluoroborate;RARECHEM AH PB 0168;2,4-Difluorophenylbo;2,4-Difluorophenylboric acid;2,4-difluorophenylboroic acid;2,4-FLUOROBENZENE BORONIC ACID
- CBNumber
- CB0385637
- Molecular Formula
- C6H5BF2O2
- Formula Weight
- 157.91
- MOL File
- 144025-03-6.mol
2,4-Difluorophenylboronic acid Property
- Melting point:
- 247-250 °C (lit.)
- Boiling point:
- 251.0±50.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
- pka
- 8.47±0.58(Predicted)
- form
- Powder
- color
- Off-white to light beige or yellow
- BRN
- 8616257
- InChI
- InChI=1S/C6H5BF2O2/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,10-11H
- InChIKey
- QQLRSCZSKQTFGY-UHFFFAOYSA-N
- SMILES
- B(C1=CC=C(F)C=C1F)(O)O
- CAS DataBase Reference
- 144025-03-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-22
- Safety Statements
- 37/39-26-36
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 465070
- Product name
- 2,4-Difluorophenylboronic acid
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $82.5
- Updated
- 2023/06/20
- Product number
- 465070
- Product name
- 2,4-Difluorophenylboronic acid
- Purity
- ≥95%
- Packaging
- 25g
- Price
- $250
- Updated
- 2023/06/20
- Product number
- D3391
- Product name
- 2,4-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $34
- Updated
- 2025/07/31
- Product number
- D3391
- Product name
- 2,4-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 25g
- Price
- $136
- Updated
- 2025/07/31
- Product number
- D447295
- Product name
- 2,4-Difluorophenylboronic acid
- Packaging
- 50g
- Price
- $275
- Updated
- 2021/12/16
2,4-Difluorophenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
off-white to light beige or yellow powder
Uses
suzuki reaction
Uses
2,4-Difluorophenylboronic Acid is used as a reagent in suzuki-miyaura coupling reactions such as in the synthesis of enantiomerically pure 3,3''-bis-arylated BINOL derivatives. Also used in the synthesis of highly efficient phospherescent iridium (III) complexes which are used for light-emiiting diodes.
Synthesis
121-43-7
144025-04-7
144025-03-6
(B) A solution of trimethyl borate (25.98 g, 0.25 mol, Fluka) and 2,4-difluorophenylmagnesium bromide (0.25 mol) in tetrahydrofuran (200 mL) was added dropwise simultaneously to a reactor containing tetrahydrofuran (125 mL) over a period of 1 h under nitrogen protection, maintaining the reaction temperature at -15 °C. The reaction was carried out by stirring the reaction mixture for 15 min. After the dropwise addition, the reaction mixture was continued to be stirred at -15°C for 15 minutes. Subsequently, the temperature of the reaction system was raised to 0 °C and water (17.5 mL) and 10% sulfuric acid solution (125 mL) were slowly added over 10 and 15 min, respectively. After the reaction was complete, water (250 mL) was added to ensure complete dissolution of the product, which was subsequently extracted with ether (3 x 150 mL). The organic phases were combined and concentrated to dryness under reduced pressure to afford the crude 2,4-difluorophenylboronic acid (36.98 g, 90% purity, 84.3% yield), which was used directly in the subsequent cross-coupling reaction without further purification.
References
[1] Patent: US5312975, 1994, A
[2] Patent: EP494419, 1992, A2
[3] Patent: US5312975, 1994, A
[4] Patent: EP494419, 1992, A2
[5] Patent: US2012/309971, 2012, A1. Location in patent: Page/Page column 2-3
2,4-Difluorophenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-Difluorophenylboronic acid Suppliers
- Tel
- 022-83719186 13212251377
- Fax
- 086-022-8789 9925
- 18522618860@163.com
- Country
- China
- ProdList
- 79
- Advantage
- 55
- Tel
- 0556-5032306 18917961636
- wtx@bayeebio.com
- Country
- China
- ProdList
- 239
- Advantage
- 61
- Tel
- 13052376889 13681663468
- 2851911691@qq.com
- Country
- China
- ProdList
- 824
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
View Lastest Price from 2,4-Difluorophenylboronic acid manufacturers
- Product
- 2,4-Difluorophenylboronic acid 144025-03-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%Min
- Supply Ability
- 1000kg
- Release date
- 2023-03-13
- Product
- Difluorophenylboronic acid 144025-03-6
- Price
- US $40.00/KG
- Min. Order
- 1KG
- Purity
- 99
- Supply Ability
- 10 tons
- Release date
- 2021-08-12
- Product
- 2,4-Difluorophenylboronic acid 144025-03-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10