Tolperisone

Application

Product Name: Tolperisone
CAS No.: 728-88-1
Chemical Name: Tolperisone
Synonyms: mydeton;Mideton;Mydetone;AKOS 91983;NSC 107321;TOLPERISONE;dl-Tolperisone;Atmosgen free base;Besnoline free base;Tolperisone USP/EP/BP
CBNumber: CB0393580
Molecular Formula: C16H23NO
Formula Weight: 245.36
MOL File: 728-88-1.mol

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Tolperisone Property

Melting point:: 176.5°C
Boiling point:: 388.33°C (rough estimate)
Density: 0.9672 (rough estimate)
refractive index: 1.5500 (estimate)
pka: 8.47±0.10(Predicted)
CAS DataBase Reference: 728-88-1(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0008765
Product name: TOLPERISONE
Purity: 95.00%
Packaging: 1KG
Price: $6985.44
Updated: 2021/12/16

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Tolperisone Chemical Properties,Usage,Production

Application

It dilates blood vessels and centrally relaxes muscles. It directly dilates vascular smooth muscle and inhibits polysynaptic reflexes, reduces skeletal muscle tone, relieves muscle rigidity and clonus caused by brain and spinal cord injuries, and increases peripheral blood flow. It is rapidly absorbed orally, reaching peak absorption in 1-2 hours. Clinically, it is used to treat occlusive vascular diseases such as atherosclerosis and endovascular inflammation; it is also used to treat post-stroke sequelae, cerebral palsy, and spinal cord and peripheral nerve diseases. It has a certain therapeutic effect on symptoms such as headache, dizziness, insomnia, limb numbness, memory loss, and tinnitus caused by cerebrovascular diseases.

Originator

Tolperisone hydrochloride,Shanghai Abochem Chemical Co.

Definition

ChEBI: 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone is an aromatic ketone.

Manufacturing Process

To 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added an excess of thionyl chloride and the reaction mixture refluxed until completed. It was then taken to dryness under reduced pressure and the residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate. An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone was purified by distilling the base (boiling point 106-107°C/1 mm) and reconverting to the hydrochloride, melting point 216-217°C.

brand name

Tolperisone Hydrochloride is JAN.

Therapeutic Function

Muscle relaxant, Vasodilator

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 42, p. 1676, 1994 DOI: 10.1248/cpb.42.1676

Tolperisone Preparation Products And Raw materials

Raw materials

Preparation Products

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Tolperisone Suppliers

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View Lastest Price from Tolperisone manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Tolperisone 728-88-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

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AKOS 91983

1-piperidino-2-methyl-3-(p-tolyl)-3-propanone

2,4’-dimethyl-3-piperidino-propiophenon

2-methyl-3-piperidino-1-p-tolylpropan-1-one

mydeton

TOLPERISONE

α,4'-Dimethyl-β-piperidinopropiophenone

2-methyl-1-(4-methylphenyl)-3-piperidin-1-yl-propan-1-one

2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one

2-methyl-1-(4-methylphenyl)-3-piperidino-propan-1-one

1-Propanone, 2-Methyl-1-(4-Methylphenyl)-3-(1-piperidinyl)-

2'4-Dimethyl-3-PiperidylPropiophenone

1-Propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)- (9CI)

dl-Tolperisone

Mideton

Mydetone

NSC 107321

Propiophenone, 2,4'-dimethyl-3-piperidino- (7CI, 8CI)

Tolperisone (base and/or unspecified salts)

2,4'-Dimethyl-3-piperidinopropiophenone

2-Methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone

Tolperisone USP/EP/BP

TolperisoneQ: What is Tolperisone Q: What is the CAS Number of Tolperisone Q: What is the storage condition of Tolperisone Q: What are the applications of Tolperisone

728-88-1 Tolperisone C16H23NO

Atmosgen free base

Besnoline free base

Tolperisone free base

2-methyl-3-(piperidin-1-yl)-1-(p-tolyl)propan-1-one

728-88-1