Tolperisone Property

Melting point:

176.5°C

Boiling point:

388.33°C (rough estimate)

Density 

0.9672 (rough estimate)

refractive index 

1.5500 (estimate)

pka

8.47±0.10(Predicted)

CAS DataBase Reference

728-88-1(CAS DataBase Reference)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

Tolperisone Chemical Properties,Usage,Production

Originator

Tolperisone hydrochloride,Shanghai Abochem Chemical Co.

Definition

ChEBI: 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone is an aromatic ketone.

Manufacturing Process

To 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added an excess of thionyl chloride and the reaction mixture refluxed until completed. It was then taken to dryness under reduced pressure and the residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate. An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone was purified by distilling the base (boiling point 106-107°C/1 mm) and reconverting to the hydrochloride, melting point 216-217°C.

brand name

Tolperisone Hydrochloride is JAN.

Therapeutic Function

Muscle relaxant, Vasodilator

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 42, p. 1676, 1994 DOI: 10.1248/cpb.42.1676