Aceclofenac
Description Mechanism of Action Precautions- Product Name
- Aceclofenac
- CAS No.
- 89796-99-6
- Chemical Name
- Aceclofenac
- Synonyms
- Zerodol;Preservex;Gerbin;Falcol;Airtal;PR-82/3;Tresquim;Biofenac;Aceclofar;Acelofenac
- CBNumber
- CB0402570
- Molecular Formula
- C16H13Cl2NO4
- Formula Weight
- 354.18
- MOL File
- 89796-99-6.mol
Aceclofenac Property
- Melting point:
- 149-153°C
- Boiling point:
- 486.0±45.0 °C(Predicted)
- Density
- 1.455±0.06 g/cm3(Predicted)
- RTECS
- CY1577900
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO
- form
- powder
- pka
- 2.60±0.10(Predicted)
- color
- off-white to light tan
- Water Solubility
- 32mg/L(32 ºC)
- Merck
- 14,22
- InChIKey
- MNIPYSSQXLZQLJ-UHFFFAOYSA-N
- CAS DataBase Reference
- 89796-99-6(CAS DataBase Reference)
- EPA Substance Registry System
- Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, carboxymethyl ester (89796-99-6)
Safety
- Hazard Codes
- T,N
- Risk Statements
- 25-36-50/53
- Safety Statements
- 26-45-60-61
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29224999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A8861
- Product name
- Aceclofenac
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $31.12
- Updated
- 2024/03/01
- Product number
- PHR3166
- Product name
- Aceclofenac
- Purity
- pharmaceutical secondary standard, certified reference material
- Packaging
- 100MG
- Price
- $668
- Updated
- 2024/03/01
- Product number
- A8861
- Product name
- Aceclofenac
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $300
- Updated
- 2024/03/01
- Product number
- A2484
- Product name
- Aceclofenac
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $16
- Updated
- 2024/03/01
- Product number
- A2484
- Product name
- Aceclofenac
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $42
- Updated
- 2024/03/01
Aceclofenac Chemical Properties,Usage,Production
Description
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAIDs) that is commonly prescribed for people with painful rheumatic conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
The drug should not be given to children, breastfeeding mothers, and people with porphyria. Pregnant women should not also be given aceclofenac as they risk developing patent ductus arteriosus in the neonate.
Mechanism of Action
Aceclofenac acts by inhibiting the effect of natural substances known as cyclooxygenase (COX) enzymes. Notably, these enzymes are responsible for making other chemicals in the body, namely prostaglandins. The prostaglandins are normally produced at sites of damages or injury cause inflammation and pain. By blocking the influence of COX enzymes, production of prostaglandins is minimized, meaning that the swelling and pain is eased.
Precautions
Before taking aceclofenac, it is essential to tell the doctor if one has ever had an allergic reaction to any other NSAID, for instance, diclofenac, aspirin, indomethacin, and naproxen; whether one has allergic disorders such as asthma. It is important to alert the doctor if an individual has a heart condition or problem with circulation or blood vessels. Moreover, inform the physician if one has connective tissue disorder, for instance, lupus erythematosus. One should not take the drug if he/she has high blood pressure or has blood-clotting problems.
Description
Aceclofenac is a nonsteroidal antiinflammatory agent with analgesic and antipyretic properties. It is reported to be useful in the treatment of osteoarthritis, rheumatoid arthritis and pain associated with minor surgical procedures. Compared to ketoprofen in the treatment of rheumatoid arthritis, aceclofenac is substantially faster acting.
Chemical Properties
White Crystalline Solid
Originator
Prodes (Prodesfarma) (Spain)
Uses
Labeled Aceclofenac, intended for use as an internal standard for the quantification of Aceclofenac by GC- or LC-mass spectrometry.
Uses
Aceclofenac is a non-steroidal, anti-inflammatory drug (NSAID) with potent inhibitory activity in several models of inflammation. It is used for the treatment of osteoarthritis and rheumatoid arthritis. It is a Biopharmaceutics classification system class II (BCS class I) drug which has an intermediate half-life of 3-4h and undergoes substantial first pass metabolism. aceclofenac is available either in oral form (tablet) or in topical form (gel).
Definition
ChEBI: Aceclofenac is a monocarboxylic acid that is the carboxymethyl ester of diclofenac. A non-steroidal anti-inflammatory drug related to diclofenac, it is used in the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It has a role as an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a non-steroidal anti-inflammatory drug and a non-narcotic analgesic. It is a monocarboxylic acid, a carboxylic ester, a secondary amino compound, an amino acid and a dichlorobenzene. It derives from a diclofenac.
brand name
Airtal; Gerbin
Therapeutic Function
Analgesic, Antiinflammatory
Biochem/physiol Actions
Non-steroidal, anti-inflammatory drug (NSAID), with selectivity for COX-2 over COX-1.
Clinical Use
NSAID and analgesic
Drug interactions
Potentially hazardous interactions with other drugs
ACE inhibitors and angiotensin-II antagonists:
antagonism of hypotensive effect; increased risk of
nephrotoxicity and hyperkalaemia.
Analgesics: avoid concomitant use of 2 or more
NSAIDs, including aspirin (increased side effects);
avoid with ketorolac (increased risk of side effects
and haemorrhage).
Antibacterials: possible increased risk of convulsions
with quinolones.
Anticoagulants: effects of coumarins and
phenindione enhanced; possibly increased risk of
bleeding with heparins, dabigatran and edoxaban -
avoid long term use with edoxaban.
Antidepressants: increased risk of bleeding with
SSRIs and venlaflaxine.
Antidiabetic agents: effects of sulphonylureas enhanced.
Antiepileptics: possibly increased phenytoin
concentration.
Antivirals: increased risk of haematological toxicity
with zidovudine; concentration possibly increased by
ritonavir.
Ciclosporin: may potentiate nephrotoxicity
Cytotoxics: reduced excretion of methotrexate;
increased risk of bleeding with erlotinib.
Diuretics: increased risk of nephrotoxicity;
antagonism of diuretic effect, hyperkalaemia with
potassium-sparing diuretics.
Lithium: excretion decreased.
Pentoxifylline: increased risk of bleeding.
Tacrolimus: increased risk of nephrotoxicity.
Metabolism
About two-thirds of a dose is excreted in the urine, mainly as hydroxymetabolites, the principal one being 4-hydroxyaceclofenac. A small amount is converted to diclofenac.
Aceclofenac Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Aceclofenac manufacturers
- Product
- Aceclofenac 89796-99-6
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-04-24
- Product
- Aceclofenac 89796-99-6
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99.0%~101.0%; BP2018
- Supply Ability
- 15tons/month
- Release date
- 2021-06-05
- Product
- Aceclofenac 89796-99-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-13