3-BROMOINDOLE-2-CARBOXYLIC ACID
- Product Name
- 3-BROMOINDOLE-2-CARBOXYLIC ACID
- CAS No.
- 28737-33-9
- Chemical Name
- 3-BROMOINDOLE-2-CARBOXYLIC ACID
- Synonyms
- 3-BROMOINDOLE-2-CARBOXYLIC ACID;3-bromo-1H-indole-2-carboxylate;3-BroMoindole-2-carboxylic Acid, 97+%;1H-Indole-2-carboxylic acid, 3-broMo-;3-BROMOINDOLE-2-CARBOXYLIC ACID, 96+%
- CBNumber
- CB0413459
- Molecular Formula
- C9H6BrNO2
- Formula Weight
- 240.05
- MOL File
- 28737-33-9.mol
3-BROMOINDOLE-2-CARBOXYLIC ACID Property
- Melting point:
- 185-188 °C
- Boiling point:
- 452.1±30.0 °C(Predicted)
- Density
- 1.838±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 3.09±0.30(Predicted)
- color
- Off-white
- CAS DataBase Reference
- 28737-33-9
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-21/22-36-22
- Safety Statements
- 36/37/39-26
- HazardClass
- IRRITANT
- HS Code
- 29339980
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B688978
- Product name
- 3-Bromoindole-2-carboxylicacid
- Packaging
- 2.5g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 047396
- Product name
- 3-Bromo-1H-indole-2-carboxylic acid
- Purity
- >95%
- Packaging
- 500mg
- Price
- $244
- Updated
- 2021/12/16
- Product number
- W5138
- Product name
- 3-Bromo-1H-indole-2-carboxylicacid
- Packaging
- 5g
- Price
- $251
- Updated
- 2021/12/16
- Product number
- FB165054
- Product name
- 3-Bromo-1H-indole-2-carboxylic acid
- Packaging
- 5G
- Price
- $300
- Updated
- 2021/12/16
- Product number
- 047396
- Product name
- 3-Bromo-1H-indole-2-carboxylic acid
- Purity
- >95%
- Packaging
- 1g
- Price
- $304
- Updated
- 2021/12/16
3-BROMOINDOLE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Chemical Properties
Pinkish-beige crystalline powder
Uses
3-Bromoindole-2-carboxylic acid has been used to study the ?effect of Mimetic CDK9 Inhibitors on HIV-1-Activated Transcription.
Synthesis
91348-45-7
28737-33-9
General procedure for the synthesis of 3-bromoindole-2-carboxylic acid from ethyl 3-bromoindole-2-carboxylate: ethyl 3-bromoindole-2-carboxylate (54.40 g, 203 mmol) was dissolved in ethanol (600 mL), and a solution of water (50 mL) and sodium hydroxide (20.20 g, 505 mmol) was added, and the reaction was carried out at reflux for 1 hour. After completion of the reaction, the mixture was cooled and the sodium salt of the title compound was collected by filtration. The sodium salt was dissolved in water, acidified with aqueous 3N hydrochloric acid to pH < 7 and then extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting crude product was recrystallized with ethyl acetate to give the white solid product 3-bromoindole-2-carboxylic acid (47.1 g, 88% yield). Melting point 201-203°C.
References
[1] Patent: US5684032, 1997, A
[2] Patent: WO2008/154271, 2008, A1. Location in patent: Page/Page column 88
[3] Nippon Kagaku Zasshi, 1957, vol. 78, p. 1798
[4] Chem.Abstr., 1960, p. 1487
[5] Chemische Berichte, 1923, vol. 56, p. 1024
3-BROMOINDOLE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-BROMOINDOLE-2-CARBOXYLIC ACID manufacturers
- Product
- 3-BROMOINDOLE-2-CARBOXYLIC ACID 28737-33-9
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%;99%
- Supply Ability
- 500g; 1kg; 10kg; 25kg
- Release date
- 2020-01-08
- Product
- 4-BROMO-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE 28737-33-9
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%;99%
- Supply Ability
- 500g; 1kg; 10kg; 25kg
- Release date
- 2020-01-08