1-Methyl-4-pyrazole boronic acid pinacol ester

Product Name: 1-Methyl-4-pyrazole boronic acid pinacol ester
CAS No.: 761446-44-0
Chemical Name: 1-Methyl-4-pyrazole boronic acid pinacol ester
Synonyms: 1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE;1-METHYLPYRAZOLE-4-BORONIC ACID PINACOL ESTER;1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-METHYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER;1H-Pyrazole, 1-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;1-Methyl-4-(4;Angelica oil 8015-64-3;e-4-boronic acid pinacoL;1-Methylpyrazole-4-boroni...;1-Methyl-4-(4,4,5,5-Tetramethy
CBNumber: CB0414153
Molecular Formula: C10H17BN2O2
Formula Weight: 208.07
MOL File: 761446-44-0.mol

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1-Methyl-4-pyrazole boronic acid pinacol ester Property

Melting point:: 59-64 °C(lit.)
Boiling point:: 308.3±15.0 °C(Predicted)
Density: 1.05±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (slightly), Methanol (Slightly)
pka: 2.09±0.10(Predicted)
form: Crystals
color: Off-white to yellow
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-12-13(5)7-8/h6-7H,1-5H3
InChIKey: UCNGGGYMLHAMJG-UHFFFAOYSA-N
SMILES: N1(C)C=C(B2OC(C)(C)C(C)(C)O2)C=N1
CAS DataBase Reference: 761446-44-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,F,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Irritant/Flammable
TSCA: No
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 595314
Product name: 1-Methylpyrazole-4-boronic acid pinacol ester
Purity: 95%
Packaging: 1g
Price: $33.88
Updated: 2024/03/01

Sigma-Aldrich

Product number: 595314
Product name: 1-Methylpyrazole-4-boronic acid pinacol ester
Purity: 95%
Packaging: 5g
Price: $114.6
Updated: 2024/03/01

TCI Chemical

Product number: M2339
Product name: 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity: >98.0%(GC)
Packaging: 1g
Price: $52
Updated: 2024/03/01

TCI Chemical

Product number: M2339
Product name: 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity: >98.0%(GC)
Packaging: 5g
Price: $66
Updated: 2024/03/01

Alfa Aesar

Product number: H53139
Product name: 1-Methyl-1H-pyrazole-4-boronic acid pinacol ester, 97%
Packaging: 1g
Price: $108.65
Updated: 2024/03/01

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1-Methyl-4-pyrazole boronic acid pinacol ester Chemical Properties,Usage,Production

Chemical Properties

White to light yellow crystal powde

Uses

suzuki reaction

Uses

1-Methyl-4-pyrazole boronic acid pinacol ester is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.

Synthesis

To the solution of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (0.40 g, 2.06 mmol) in THF (10 mL) was added NaH (0.1.00 g, 4.12 mmol) followed by methyl iodide (0.25 mL, 4.12 mmol) at 0° C and the reaction mixture was stirred at ambient temperature for 4 hr. The reaction was quenched with saturated NH4Cl solution (20 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic layers were washed with brine (20 mL), dried over sodium sulfate, and distilled under reduced pressure to obtain 1-Methyl-4-pyrazole boronic acid pinacol ester.

1-Methyl-4-pyrazole boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Trimethyl borate Pinacol Potassium hydroxide 4-Bromopyrazole Tetrahydrofuran 5A molecular sieve Methyl bromide Iodomethane n-Butyllithium

Preparation Products

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1-Methyl-4-pyrazole boronic acid pinacol ester Suppliers

Americas 1 Belgium 1 China 352 Europe 1 France 1 Germany 6 India 13 Italy 1 Japan 3 Switzerland 3 United Kingdom 8 United States 35 Global 425

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

Junsei Chemical Co.,Ltd.

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Email: eihon@junsei.co.jp
Country: Japan
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Wako Pure Chemical Industries, Ltd.

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Email: labchem-tec@wako-chem.co.jp
Country: Japan
ProdList: 6819
Advantage: 80

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View Lastest Price from 1-Methyl-4-pyrazole boronic acid pinacol ester manufacturers

Henan Fengda Chemical Co., Ltd

Product: 1-Methylpyrazole-4-boronic acid pinacol ester 761446-44-0
Price: US $30.00-2.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: g-kg-tons,free sample is available
Release date: 2024-01-03

Henan Aochuang Chemical Co.,Ltd.

Product: 1-Methyl-4-pyrazole boronic acid pinacol ester 761446-44-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-16

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 761446-44-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

761446-44-0, 1-Methyl-4-pyrazole boronic acid pinacol esterRelated Search:

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1-METHYL- 4-PYRAZOLEBORONIC ACID PINACOL ESTER

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4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methylpyrazole

1-Methyl-4-(4,4,5,5-Tetramethy

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1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 2-(1-Methyl-1H-pyrazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1-Methylpyrazole-4-boronic acid pinacol ester 95%

1-Methylpyrazole-4-boronic acid pinacol ester 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Methyl-1H-pyrazole-4-boronic acid, pinacol ester 99%

1-Methyl-1H-pyrazole-4-boronic acid pinacol

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3-hydroxy-2,3-diMethylbutan-2-yl hydrogen 1-Methyl-1H-pyrazol-4-ylboronate

1-METHYL-4-1H-PYRAZOLEBORONIC ACID, PINACOL ESTER

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1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE

1-METHYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER

1-METHYLPYRAZOLE-4-BORONIC ACID PINACOL ESTER

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1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole ,95%

1-Methylpyrazole-4-boronic acid pinacol ester ,98%

1-Methylpyrazole-4-boroni...

1-Methyl-4-(4

1-Methy-4-(4,4,5,5,-tertamethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Methylpyrazole-4-boronic acid pinacol ester (Related Reference)

1-MethylPyrazole-4-Boronic acid Pinacolate

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1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole&gt

e-4-boronic acid pinacoL

(1-METHYL-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER

2-(1-Methyl-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1- methylpyrazole -4- boracic acid methyl alcohol ester

Angelica oil 8015-64-3

Tranexamic Acid Impurity 27-13C2

N-Methylpyrazole-4-boronicacidpinacolester

761446-44-0

761446-18-6

76146-44-0

C10H17BN2O2

C10H19BN2O3

Boronate Esters

Boronic Acids and Derivatives

Chemical Synthesis

Heteroaryl Boronate Esters

Organometallic Reagents

Heterocyclic Building Blocks

Organoborons

Pyrazole

Boronic acid