ChemicalBook > CAS DataBase List > 1-(4-METHYLPHENYLSULFONYL)-1,2,4-TRIAZOLE

1-(4-METHYLPHENYLSULFONYL)-1,2,4-TRIAZOLE

Product Name
1-(4-METHYLPHENYLSULFONYL)-1,2,4-TRIAZOLE
CAS No.
13578-51-3
Chemical Name
1-(4-METHYLPHENYLSULFONYL)-1,2,4-TRIAZOLE
Synonyms
1-Tosyl-1,2,4-triazole;Posaconazole Impurity 153;1-Tosyl-1H-1,2,4-triazole;1-(4-Toluenesulfonyl)-1,2,4-triazole;1-(p-Toluenesulfonyl)-1,2,4-triazole;1-(4-METHYLPHENYLSULFONYL)-1,2,4-TRIAZOLE;1-(p-Toluenesulfonyl)-1,2,4-triazole;MPST 1-(4-Methylphenylsulfonyl)-1,2,4-triazole;1-(p-Toluenesulfonyl)-1,2,4-triazole≥ 98%(HPLC);1H-1,2,4-Triazole, 1-[(4-methylphenyl)sulfonyl]-
CBNumber
CB0419794
Molecular Formula
C9H9N3O2S
Formula Weight
223.25
MOL File
13578-51-3.mol
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1-(4-METHYLPHENYLSULFONYL)-1,2,4-TRIAZOLE Property

Melting point:
106-108℃
Boiling point:
417.2±38.0 °C(Predicted)
Density 
1.39
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
-0.84±0.12(Predicted)
color 
White to Almost white
CAS DataBase Reference
13578-51-3
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Safety

HS Code 
2935.90.9500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
T3187
Product name
1-(p-Toluenesulfonyl)-1,2,4-triazole
Purity
>98.0%(HPLC)
Packaging
1g
Price
$34
Updated
2025/07/31
TCI Chemical
Product number
T3187
Product name
1-(p-Toluenesulfonyl)-1,2,4-triazole
Purity
>98.0%(HPLC)
Packaging
5g
Price
$96
Updated
2021/12/16
TRC
Product number
T686955
Product name
1-Tosyl-1H-1,2,4-triazole
Packaging
50mg
Price
$45
Updated
2021/12/16
Ark Pharm
Product number
P000223888
Product name
1-Tosyl-1H-1,2,4-triazole
Purity
97%
Packaging
25g
Price
$50
Updated
2021/12/16
Chem-Impex
Product number
31226
Product name
1-(p-Toluenesulfonyl)-1,2,4-triazole,≥99%(HPLC)
Purity
≥99%(HPLC)
Packaging
5G
Price
$52.42
Updated
2021/12/16
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1-(4-METHYLPHENYLSULFONYL)-1,2,4-TRIAZOLE Chemical Properties,Usage,Production

Chemical Properties

White to almost white crystals or powder

Synthesis

288-88-0

98-59-9

13578-51-3

1,2,4-Triazole (9.28 g) was suspended in dichloromethane (110 mL) and dried by adding molecular sieves. Subsequently, triethylamine (13.6 g) was added to the suspension to completely dissolve 1,2,4-triazole. Under stirring, p-toluenesulfonyl chloride (25.62 g) was slowly added, taking about 1 hour. After addition, the reaction mixture was continued to be stirred for 30 minutes and then stirred overnight at room temperature. After completion of the reaction, the precipitated salt was removed by filtration. The filtrate was sequentially washed with water and dried with anhydrous sodium sulfate. After filtration to remove the desiccant, the filtrate was concentrated by rotary evaporator. Cyclohexane (300 mL) was added to the concentrated residue and left overnight to crystallize the product. The white crystals were collected by filtration, washed with cyclohexane (50 mL) and dried in an oven at 50 °C to give 1-(4-methylbenzenesulfonyl)-1,2,4-triazole 25.1 g in 83.7% yield, melting point 105-107 °C.

References

[1] Carbohydrate Research, 2003, vol. 338, # 5, p. 451 - 453
[2] Journal of Organic Chemistry, 2010, vol. 75, # 8, p. 2722 - 2725
[3] Patent: US2008/76933, 2008, A1. Location in patent: Page/Page column 3-5
[4] Patent: EP1258480, 2002, A1. Location in patent: Page 37
[5] Journal of Chemical Research, 2016, vol. 40, # 2, p. 101 - 106

1-(4-METHYLPHENYLSULFONYL)-1,2,4-TRIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-METHYLPHENYLSULFONYL)-1,2,4-TRIAZOLE Suppliers

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View Lastest Price from 1-(4-METHYLPHENYLSULFONYL)-1,2,4-TRIAZOLE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
1-(4-METHYLPHENYLSULFONYL)-1,2,4-TRIAZOLE 13578-51-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-26
Honest Joy Holdings Limited
Product
1-(4-Methylphenylsulfonyl)-1,2,4-triazole 13578-51-3
Price
US $0.00/KG
Min. Order
1KG
Purity
98.7%
Supply Ability
100 tons
Release date
2022-01-25
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-(4-METHYLPHENYLSULFONYL)-1,2,4-TRIAZOLE 13578-51-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

13578-51-3, 1-(4-METHYLPHENYLSULFONYL)-1,2,4-TRIAZOLERelated Search:

Tungsten p-Toluenesulfonamide Mesitylene-2-sulfonyl chloride 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate N-(3-(DIMETHYLAMINO)-1-[(4-METHYLPHENYL)SULFONYL]-1H-1,2,4-TRIAZOL-5-YL)-N,N-DIMETHYLAMINE 1-MESITYLENESULFONYL-1,2,4-TRIAZOLE 1-[[2,4,6-Tris(isopropyl)phenyl]sulphonyl]-1H-1,2,4-triazole 1-(2,4,6-TRIISOPROPYLBENZENESULFONYL)-3-NITRO-1H-1,2,4-TRIAZOLE 1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole 1-(4-METHYLPHENYLSULFONYL)-1,2,4-TRIAZOLE 1-(p-Toluenesulfonyl)-3-nitro-1,2,4-triazole

  • 1-(4-METHYLPHENYLSULFONYL)-1,2,4-TRIAZOLE
  • 1-Tosyl-1H-1,2,4-triazole
  • 1-(p-Toluenesulfonyl)-1,2,4-triazole
  • 1-(<i>p</i>-Toluenesulfonyl)-1,2,4-triazole
  • MPST 1-(4-Methylphenylsulfonyl)-1,2,4-triazole
  • 1-(4-Toluenesulfonyl)-1,2,4-triazole
  • 1-(p-Toluenesulfonyl)-1,2,4-triazole≥ 98%(HPLC)
  • 1-Tosyl-1,2,4-triazole
  • 1H-1,2,4-Triazole, 1-[(4-methylphenyl)sulfonyl]-
  • Posaconazole Impurity 153
  • 13578-51-3