PyBOP

Product Name: PyBOP
CAS No.: 128625-52-5
Chemical Name: PyBOP
Synonyms: PYBOP;BOPP;BOP REAGENT;((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tri(pyrrolidin-1-yl)phosphoniuM hexafluorophosphate(V);(BENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE;BENZOTRIAZOLE-1-YL-OXY-TRIS-PYRROLIDINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE;1H-BENZOTRIAZOL-1-YLOXYTRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE;[(1H-Benzotriazol-1-yl)oxy][tri(pyrrolidin-1-yl)]phosphonium hexafluorophosphate;BYPOP;PYBOP(R)
CBNumber: CB6434717
Molecular Formula: C18H28F6N6OP2
Formula Weight: 520.39
MOL File: 128625-52-5.mol

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PyBOP Property

Melting point:: 154-156 °C (dec.)(lit.)
Density: 1.438 at 20℃
vapor pressure: 0-0Pa at 20-50℃
storage temp.: 2-8°C
solubility: methanol: 25 mg/mL, clear
form: Fine Crystalline Powder
color: White to off-white
Sensitive: Moisture Sensitive
BRN: 3584612
InChI: InChI=1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1
InChIKey: BYCLGHOAELJLOF-UHFFFAOYSA-M
SMILES: [P+](ON1N=NC2C=CC=CC1=2)(N1CCCC1)(N1CCCC1)N1CCCC1.[P-](F)(F)(F)(F)(F)F
LogP: -0.3 at 26℃ and pH3.5-3.7
CAS DataBase Reference: 128625-52-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 37/38-44-36/37/38
Safety Statements: 26-36-24/25-37/39
RIDADR: UN 1325 4.1/PG 2
WGK Germany: 3
F: 8-10-21
Hazard Note: Irritant
HS Code: 29339980

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.51009
Product name: PyBOP
Purity: Novabiochem?
Packaging: 25g
Price: $123
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.51009
Product name: PyBOP
Purity: Novabiochem?
Packaging: 100g
Price: $367
Updated: 2024/03/01

Sigma-Aldrich

Product number: 12805
Product name: (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
Purity: purum, ≥97.0% (TLC)
Packaging: 1g
Price: $81.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 12805
Product name: (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
Purity: purum, ≥97.0% (TLC)
Packaging: 5G
Price: $96
Updated: 2024/03/01

Sigma-Aldrich

Product number: 12805
Product name: (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
Purity: purum, ≥97.0% (TLC)
Packaging: 25g
Price: $298
Updated: 2024/03/01

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PyBOP Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

One of the most convenient coupling reagents for peptide synthesis without carcinogenic by-products. It replaces BOP reagent. This is especially suitable for solid-phase peptide synthesis, avoids racemization.

Uses

1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl) phosphonium hexafluorophosphate (PyBOP) is a peptide coupling reagent utilized in solid phase peptide synthesis. It is also used as a substitute for the (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.

Uses

PyBOP is a reagent for: Synthesis of single labeled oligonucleotides that fluoresce upon matched hybridization
Generation of endocrine disruptor chemical binders
Cycloaddition to template-assembled multivalent peptide conjugates

Definition

PyBOP (benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate) coupling reagent was selected for the peptidic bond formation. This selection was because PyBOP is efficient and could generate less toxic byproducts. PyBOP is an efficient coupling reagent utilized in solid-phase peptide synthesis. It reacts similarly to BOP, but its byproduct is not highly carcinogenic. PyBOP was utilized in the solid-phase synthesis of the tetrapeptide H-Ile-Ala-Leu-Pro-OH on 2-chlorotrityl resin. In contrast to uronium-based coupling reagents, PyBOP does not form guanidinated byproducts when used in excess. This makes it useful in fragment condensation reactions and head-to-tail cyclizations[1].

General Description

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.

References

[1] Maharani, R. et al. “Good coupling performance of PyBOP in the solid-phase synthesis of tetrapeptide, OH-Pro-Leu-Ala-Ileu-NH2.” 2017. 0.

PyBOP Preparation Products And Raw materials

Raw materials

Preparation Products

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PyBOP Suppliers

Americas 1 Belgium 2 Canada 5 China 392 Europe 6 France 3 Germany 8 India 23 Israel 2 Italy 1 Japan 7 Poland 1 South Korea 1 Switzerland 5 Ukraine 1 United Kingdom 18 United States 73 Global 549

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-68311833 13962195826
Fax: 0512-68417696
Email: wuhao@highfine.com
Country: China
ProdList: 499
Advantage: 75

Shaoxing Jiufu New Material Technology Co., LTD

Tel: 0575-87095566 18067860628
Email: sales@sxjiufu.com
Country: China
ProdList: 19
Advantage: 58

Shanghai Jifeng Biotechnology Co., Ltd.

Tel: 021-61263377 15023907684
Fax: 021-61263399
Email: 15800684150@163.com
Country: China
ProdList: 8131
Advantage: 58

Gill polypeptide biopharmaceutical (dalian) co., LTD

Tel: 021-61263455 13167021076
Email: amy@glschina.com
Country: China
ProdList: 8745
Advantage: 58

Shanghai Medpep Co., Ltd

Tel: 021-65566949 13901795941
Fax: 86-21-51861665
Email: market@medpep.com
Country: China
ProdList: 177
Advantage: 66

Jiangsu Jitai Peptide Technology Co., Ltd.

Tel: 18801776727
Email: sales06@gtaipeptide.com
Country: China
ProdList: 2010
Advantage: 58

Binhai gill polypeptide co. LTD

Tel: 021-61263389 13524856427
Fax: WeChat630417570
Email: Joetang@glschina.com
Country: China
ProdList: 9976
Advantage: 58

Lianyungang Guanxin Pharmaceutical Technology Co., Ltd

Tel: 15351860687
Email: 1462699602@qq.com
Country: China
ProdList: 53
Advantage: 58

Aikon International Limited

Tel: 025-58851090 13611564524
Fax: (6)02557626880
Email: lwan@aikonchem.com
Country: China
ProdList: 15951
Advantage: 58

Suzhou Nordica Biopharma Co.,LTD

Tel: 15150674956
Email: dannilee@nordicabio.com
Country: China
ProdList: 88
Advantage: 58

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View Lastest Price from PyBOP manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate 128625-52-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-09

Watson Biotechnology Co.,Ltd

Product: PyBOP Benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate 128625-52-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20MT
Release date: 2024-09-23

Hebei Weibang Biotechnology Co., Ltd

Product: Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate 128625-52-5
Price: US $25.00/ASSAYS
Min. Order: 100ASSAYS
Purity: 99.5%
Supply Ability: 100 mt
Release date: 2024-11-20

128625-52-5, PyBOPRelated Search:

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride DEPBT TSTU 5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate Diphenylphosphoryl azide 1H-Benzotriazole Hexafluorophosphoric acid Potassium hexafluorophosphate Lithium hexafluorophosphate Sodium hexafluorophosphate Hexafluorophosphate TRIS(DIETHYLAMINO)PHOSPHINE 1-Hydroxybenzotriazole hydrate 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate Hexamethylphosphorous triamide Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate

pybop?/td>

BENZOTRIAZOLYL-N-OXYTRIS-(DIMETHYLAMINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE)

(BENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE

BENZOTRIAZOL-1-YL-OXYTRIPYRROLIDINPHOSPHONIUM HEXAFLUOROPHOSPHATE

Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate

BENZOTRIAZOLE-1-YL-OXY-TRIS-DIMETHYLAMINOPHOPHONIUM

BENZOTRIAZOL-1-YLOXYTRIS(PYRROLIDINO)PHOSPHONIUM HEXAFLUOROPHOSPHATE

BENZOTRIAZOLE-1-YL-OXY-TRIS-(DIMETHYLAMINO)-PHOPHONIUM HEXAFLUOROPHOSPHATE

BENZOTRIAZOLE-1-YL-OXY-TRIS-(DIMETHYLAMINO)-PHOSPHONIUM

BENZOTRIAZOLE-1-YL-OXY-TRIS-(DIMETHYLAMINO)-PHOSPHONIUM HEXAFLUOROPHOSPHATE

BENZOTRIAZOLE-1-YL-OXY-TRIS-PYRROLIDINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE

BENZOTRIAZOLE-1-YL-OXY-TRIS-PYRRORIDINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE

BOPP

BOP REAGENT

HEXAFLUOROPHOSPHATE BOP

CASTROS REAGENT

CASTRO'S REAGENT

1H-BENZOTRIAZOL-1-YLOXYTRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE

PYBOP

PYBOP(R)

Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluoroph

Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 98%

PYBOP(R),99%

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate,PyBOP

Benzotriazol-1-yl-ox

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium he

1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 98%

PyBOP (OR) Benzotriazol-1-yloxy tripyrrolidinophosphoniuM hexafluorophosphate

PYBOP, 99% 5GR

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tri(pyrrolidin-1-yl)phosphoniuM hexafluorophosphate(V)

[(1H-Benzotriazol-1-yl)oxy][tri(pyrrolidin-1-yl)]phosphonium hexafluorophosphate

(1H-Benzotriazol-1-yloxy)(diMethylaMino)di(pyrrolidin-1-yl)phosphoniuM

Phosphorus(1+),[1-(hydroxy-kO)-1H-benzotriazolato]tri-1-pyrrolidinyl-,(T-4)-, hexafluorophosphate(1-) (1:1)

(1H-1,2,3-benzotriazol-1-yloxy)tris(pyrrolidin-1-yl)phosphanium

BENZOTRIAZOL-1-YL-OXYTRIPYRROLIDINO-PHOS PHONIUM

(BENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUM F6 PHOSPHATE

PYBOP [BENZOTRIAZOL-1-YLOXYTRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE]

Benzotriazol-1-yloxytris(pyrrolidino)phosphoniumh

Benzotriazol-1-yloxytris-(pyrrolidino)-phosphonium

Benzotriazol-1-yloxytripyrroli

Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphateBenzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate

Benzotriazol-1-yloxytris(pyrrolidino)phosphonium Hexafluorophosphate (PyBOP)

Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphat

PYBOP ((1H-BENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUMHEXAFLUOROPHOSPHATE)

Benzotriazole-1-ly-oxy-tris-pyrrolidinophosphonium hexafluorphosphate

1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate [Coupling Reagent for Peptide]

Benzotriazol-1-yl-oxytrispyrrolidinophosphonium hexafluorophosphate, 97+%

Benzotriazole-1-yl-oxy-trispyrrolidinophosphonium hexafluorophosphate ,99%

(Benzotriazol-1-yloxy)tripyrrolidinophosphoniuM hexafluorophosphate 98%

1H-Benzotriazol-1-yloxytripyrrolidinophosphoniuM hexafluorophosphate, 98.0%(LC)

1 h benzotriazole - 1 - three pyrrole alkyl six fluoride phosphate PyBOP base oxygen

enzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate≥ 99% (HPLC)

PyBOP Novabiochem

1-Benzotriazolyloxytripyrrolidinylphosphonium hexafluorophosphate

Unable to generate chemical name

BENZOTRIAZOLYL-N-OXYTRIS-(DIMETHY

Benzotriazol-1-yloxytrispyrrolidinophosphonium hexafluorophosphate, 99%, for synthesis