PyBOP
- Product Name
- PyBOP
- CAS No.
- 128625-52-5
- Chemical Name
- PyBOP
- Synonyms
- PYBOP;BOPP;BOP REAGENT;((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tri(pyrrolidin-1-yl)phosphoniuM hexafluorophosphate(V);(BENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE;BENZOTRIAZOLE-1-YL-OXY-TRIS-PYRROLIDINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE;1H-BENZOTRIAZOL-1-YLOXYTRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE;[(1H-Benzotriazol-1-yl)oxy][tri(pyrrolidin-1-yl)]phosphonium hexafluorophosphate;BYPOP;PYBOP(R)
- CBNumber
- CB6434717
- Molecular Formula
- C18H28F6N6OP2
- Formula Weight
- 520.39
- MOL File
- 128625-52-5.mol
PyBOP Property
- Melting point:
- 154-156 °C (dec.)(lit.)
- Density
- 1.438 at 20℃
- vapor pressure
- 0-0Pa at 20-50℃
- storage temp.
- 2-8°C
- solubility
- methanol: 25 mg/mL, clear
- form
- Fine Crystalline Powder
- color
- White to off-white
- Sensitive
- Moisture Sensitive
- BRN
- 3584612
- InChI
- InChI=1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1
- InChIKey
- BYCLGHOAELJLOF-UHFFFAOYSA-M
- SMILES
- [P+](ON1N=NC2C=CC=CC1=2)(N1CCCC1)(N1CCCC1)N1CCCC1.[P-](F)(F)(F)(F)(F)F
- LogP
- -0.3 at 26℃ and pH3.5-3.7
- CAS DataBase Reference
- 128625-52-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 37/38-44-36/37/38
- Safety Statements
- 26-36-24/25-37/39
- RIDADR
- UN 1325 4.1/PG 2
- WGK Germany
- 3
- F
- 8-10-21
- Hazard Note
- Irritant
- HS Code
- 29339980
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 8.51009
- Product name
- PyBOP
- Purity
- Novabiochem?
- Packaging
- 25g
- Price
- $123
- Updated
- 2024/03/01
- Product number
- 8.51009
- Product name
- PyBOP
- Purity
- Novabiochem?
- Packaging
- 100g
- Price
- $367
- Updated
- 2024/03/01
- Product number
- 12805
- Product name
- (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
- Purity
- purum, ≥97.0% (TLC)
- Packaging
- 1g
- Price
- $81.9
- Updated
- 2024/03/01
- Product number
- 12805
- Product name
- (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
- Purity
- purum, ≥97.0% (TLC)
- Packaging
- 5G
- Price
- $96
- Updated
- 2024/03/01
- Product number
- 12805
- Product name
- (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
- Purity
- purum, ≥97.0% (TLC)
- Packaging
- 25g
- Price
- $298
- Updated
- 2024/03/01
PyBOP Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
One of the most convenient coupling reagents for peptide synthesis without carcinogenic by-products. It replaces BOP reagent. This is especially suitable for solid-phase peptide synthesis, avoids racemization.
Uses
1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl) phosphonium hexafluorophosphate (PyBOP) is a peptide coupling reagent utilized in solid phase peptide synthesis. It is also used as a substitute for the (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.
Uses
PyBOP is a reagent for:
Synthesis of single labeled oligonucleotides that fluoresce upon matched hybridization
Generation of endocrine disruptor chemical binders
Cycloaddition to template-assembled multivalent peptide conjugates
Definition
PyBOP (benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate) coupling reagent was selected for the peptidic bond formation. This selection was because PyBOP is efficient and could generate less toxic byproducts. PyBOP is an efficient coupling reagent utilized in solid-phase peptide synthesis. It reacts similarly to BOP, but its byproduct is not highly carcinogenic. PyBOP was utilized in the solid-phase synthesis of the tetrapeptide H-Ile-Ala-Leu-Pro-OH on 2-chlorotrityl resin. In contrast to uronium-based coupling reagents, PyBOP does not form guanidinated byproducts when used in excess. This makes it useful in fragment condensation reactions and head-to-tail cyclizations[1].
General Description
(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.
References
[1] Maharani, R. et al. “Good coupling performance of PyBOP in the solid-phase synthesis of tetrapeptide, OH-Pro-Leu-Ala-Ileu-NH2.” 2017. 0.
PyBOP Preparation Products And Raw materials
Raw materials
Preparation Products
PyBOP Suppliers
- Tel
- +49 3493/605464
- Fax
- +49 3493/605470
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- Germany
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View Lastest Price from PyBOP manufacturers
- Product
- Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate 128625-52-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-09
- Product
- PyBOP Benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate 128625-52-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20MT
- Release date
- 2024-09-23
- Product
- Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate 128625-52-5
- Price
- US $25.00/ASSAYS
- Min. Order
- 100ASSAYS
- Purity
- 99.5%
- Supply Ability
- 100 mt
- Release date
- 2024-11-20