ChemicalBook > CAS DataBase List > (2-Bromoethyl)benzene

(2-Bromoethyl)benzene

Product Name
(2-Bromoethyl)benzene
CAS No.
103-63-9
Chemical Name
(2-Bromoethyl)benzene
Synonyms
PHENETHYL BROMIDE;2-Phenethyl bromide;2-PHENYLETHYL BROMIDE;1-BROMO-2-PHENYLETHANE;1-phenyl-2-bromoethane;Tetrabomoethane;2-phenethylbromide;-Bromoethylbenzene;β-Bromophenylethane;2-bromoethy benzene
CBNumber
CB0427485
Molecular Formula
C8H9Br
Formula Weight
185.06
MOL File
103-63-9.mol
More
Less

(2-Bromoethyl)benzene Property

Melting point:
-56 °C
Boiling point:
220-221 °C(lit.)
Density 
1.355 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.556(lit.)
Flash point:
193 °F
storage temp. 
2-8°C
solubility 
0.039g/l
form 
Liquid
color 
Clear colorless to pale yellow
Water Solubility 
INSOLUBLE
BRN 
507487
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
WMPPDTMATNBGJN-UHFFFAOYSA-N
CAS DataBase Reference
103-63-9(CAS DataBase Reference)
NIST Chemistry Reference
1-Bromo-2-phenylethane(103-63-9)
EPA Substance Registry System
Benzene, (2-bromoethyl)- (103-63-9)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-36-36/37/38
Safety Statements 
26-37/39-39
RIDADR 
UN 1993 / PGIII
WGK Germany 
3
RTECS 
CY9032000
TSCA 
Yes
HS Code 
29036990
Hazardous Substances Data
103-63-9(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B65780
Product name
(2-Bromoethyl)benzene
Purity
98%
Packaging
5g
Price
$43.3
Updated
2024/03/01
Sigma-Aldrich
Product number
1269913
Product name
Fentanyl Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$520
Updated
2024/03/01
TCI Chemical
Product number
B0594
Product name
(2-Bromoethyl)benzene
Packaging
100G
Price
$38
Updated
2024/03/01
TCI Chemical
Product number
B0594
Product name
(2-Bromoethyl)benzene
Packaging
500G
Price
$98
Updated
2024/03/01
Alfa Aesar
Product number
A12528
Product name
(2-Bromoethyl)benzene, 98%
Packaging
100g
Price
$36.2
Updated
2024/03/01
More
Less

(2-Bromoethyl)benzene Chemical Properties,Usage,Production

Description

Phenethylbromide is an analytical reference material that is structurally categorized as an organobromide. It is used in the synthesis of a variety of compounds, including fentanyl. Phenethylbromide is combined with 4-piperidinone to produce N-phenethyl-4-piperidone, which, as a precursor in the synthesis of fentanyl, is scheduled as a List I chemical in the United States. Phenethylbromide may be found as in impurity in samples of fentanyl produced using this pathway.

Chemical Properties

colourless to yellow liquid. It is miscible with ether and benzene, but insoluble in water.

Uses

(2-Bromoethyl)benzene is used in the preparation of phenelzine by reacting with hydrazine. It is also used as a starting material to prepare various beta-phenethyl derivatives, active pharmaceutical ingredients, and fragrances. It finds application as a flame retardant.

Uses

(2-Bromoethyl)benzene is an important starting material for the production of various b-phenethyl derivatives, pharmaceuticals, fragrances, and other fine chemicals.

Preparation

(2-Bromoethyl)benzene is synthesized by the reaction of phenethyl alcohol with hydrogen bromide.
Reaction: The phenethyl alcohol was heated to 110°C, hydrogen bromide was slowly introduced, and the reaction was refluxed. The reaction was completed, cooled, washed with water, 10% sodium carbonate solution, and water in turn. After drying with anhydrous potassium carbonate, fractional distillation under reduced pressure was carried out to collect fractions at 97-99°C (2.0 kPa) with a yield of over 90%.

Synthesis Reference(s)

The Journal of Organic Chemistry, 29, p. 2317, 1964 DOI: 10.1021/jo01031a051
Synthetic Communications, 20, p. 2349, 1990 DOI: 10.1080/00397919008053179

Safety

Store at 2-8° C in a tightly closed container in a dry, well-ventilated place. Containers that are opened must be carefully resealed and kept upright to prevent leakage. (2-Bromoethyl)benzene is incompatible with strong oxidizing agents. This chemical is harmful if swallowed and causes severe eye irritation.

Synthesis

Phenethylbromide is commonly synthesized through the addition of HBr to styrene via a free-radical reaction. This process is typically carried out in a glasslined reactor by introducing gaseous HBr into a solution of styrene in an inert solvent that contains a free-radical initiator. The reaction, which is fast and releases a moderate amount of heat, can be managed by introducing HBr at a rate that matches its consumption. Once all the styrene has been converted, any remaining excess HBr can be reclaimed using different methods before the solvent and product are recovered through distillation.

Purification Methods

Wash the bromide with conc H2SO4, water, aqueous 10% Na2CO3 and water again, then dry it with CaCl2 and fractionally distil it just before use. [Beilstein 5 IV 907.]

Toxics Screening Level

The Initial Threshold Screening Level (ITSL) is 2.7 μg/m3 with an annual averaging time.

References

1. Shukla, P.; Sharma, A.; Pallavi, B.; Cheng, C. H. Nickel-catalyzed reductive Heck type coupling of saturated alkyl halides with acrylates and oxabenzonorbornadiene. Tetrahedron 2015, 71 (15), 2260-2266. DOI:10.1016/J.TET.2015.02.067
2. Huang, Y. B.; Yan, L.; Chen, M. Y.; Guo, Q. X.; Fu, Y. Selective hydrogenolysis of phenols and phenyl ethers to arenes through direct C-O cleavage over ruthenium-tungsten bifunctional catalysts. Green Chem. 2015, 17 (5), 3010-3017. DOI:10.1039/C5GC00326A
3. Justice, D.E.A.D.o. Control of a chemical precursor used in the illicit manufacture of fentanyl as a List I chemical. Final rule. Federal Register 73(144), 43355-43357 (2008). PMID: 18949877

(2-Bromoethyl)benzene Preparation Products And Raw materials

Raw materials

Potassium carbonate Phenethyl alcohol

Preparation Products

1-Phenyl-1,2-ethanediol 1-(2-PHENYLETHYL)PIPERAZINE 4-Vinylbenzyl chloride N-METHYLPHENETHYLAMINE
More
Less

(2-Bromoethyl)benzene Suppliers

Americas 1 Belgium 3 Canada 1 CHINA 441 Cyprus 1 Europe 4 France 3 Germany 8 India 30 Japan 8 Poland 1 Slovakia 1 South Korea 2 Switzerland 3 The Netherlands 2 Ukraine 2 United Kingdom 16 United States 53 Global 580
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
Morre-Tec Industries, Inc.
Tel
--
Fax
--
Email
sales@morretec.com
Country
United States
ProdList
169
Advantage
64
Anisyn, Inc.
Tel
--
Fax
--
Email
sales@anisyn.com
Country
United States
ProdList
863
Advantage
0
Accela ChemBio Inc.
Tel
--
Fax
--
Email
info@accelachem.com
Country
United States
ProdList
1054
Advantage
50
BromOrganics Corporation
Tel
--
Fax
--
Email
sales@bromorganics.com
Country
United States
ProdList
1065
Advantage
58
RSA Corporation
Tel
--
Fax
--
Email
media@RSAgroup.ca
Country
United States
ProdList
343
Advantage
58
Richman Chemical Inc
Tel
--
Fax
--
Email
clk@RichmanChemical.com
Country
United States
ProdList
238
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MORRE-TEC Industries, Inc.,
Tel
--
Fax
--
Country
United States
ProdList
20
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
TCI America, Inc. (Tokyo Chemical Industry Co., Ltd.)
Tel
--
Fax
--
Email
.Crew@tcichemicals.com
Country
United States
ProdList
3164
Advantage
58
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United States
ProdList
4583
Advantage
58
Tosoh USA, Inc.
Tel
--
Fax
--
Email
info@tosoh.com.sg
Country
United States
ProdList
68
Advantage
51
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Anvia Chemicals, LLC
Tel
--
Fax
--
Email
sales@anviachem.com
Country
United States
ProdList
3933
Advantage
0
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
NetQem
Tel
--
Fax
--
Email
sales@netqem.us
Country
United States
ProdList
1641
Advantage
38
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
ChemSampCo, Inc.
Tel
--
Fax
--
Email
sales@chemsampco.com
Country
United States
ProdList
3585
Advantage
60
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Narchem Corporation
Tel
--
Fax
--
Email
sales@narchem.com
Country
United States
ProdList
2813
Advantage
60
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
Dishman Europe Ltd
Tel
--
Fax
--
Email
info@dishman-europe.com
Country
United States
ProdList
622
Advantage
58
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
Acros Organics USA
Tel
--
Fax
--
Email
eveleth@fisherchem.com
Country
United States
ProdList
3846
Advantage
81
Fisher Scientific
Tel
--
Fax
--
Email
sales@fishersci.com
Country
United States
ProdList
2337
Advantage
86
Esprit Chemical Company
Tel
--
Fax
--
Email
admin@esprixtech.com
Country
United States
ProdList
1616
Advantage
55
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
Pechiney
Tel
--
Fax
--
Email
chemicals@pechiney.com
Country
United States
ProdList
606
Advantage
55
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67
Richman Chemical Inc.
Tel
--
Fax
--
Email
kac@richmanchemical.com
Country
United States
ProdList
692
Advantage
67
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
More
Less

View Lastest Price from (2-Bromoethyl)benzene manufacturers

Dorne Chemical Technology co. LTD
Product
(2-Bromoethyl)benzene 103-63-9
Price
US $10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
10 tons
Release date
2024-03-26
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
(2-Bromoethyl) Benzene 103-63-9
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-10
Hebei Junhua Import and Export Co., LTD
Product
(2-Bromoethyl)benzene 103-63-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000
Release date
2025-03-31

103-63-9, (2-Bromoethyl)benzeneRelated Search:

Bromoxynil octanoate Ethylbenzene 1,2-Dibromobenzene 2-Bromofluorobenzene Brompheniramine Styrene oxide Decabromodiphenyl Ethane 2-Bromoacetophenone Benzene Rocuronium bromide 4-Bromoanisole Ethidium bromide Allyl bromide Vecuronium bromide Bromobenzene 3-Bromoanisole Brompheniramine hydrogen maleate 2-Bromobenzonitrile Phenyl Ethyl Bromide

  • 1-BROMO-2-PHENYLETHANE
  • PHENYL ETHYL BROMIDE
  • PHENETHYL BROMIDE
  • (2-bromoethyl)-benzen
  • .beta.-Phenylethylbromide
  • 2-Phenethyl bromide
  • 2-phenethylbromide
  • 2-Phenyl-1-bromoethane
  • Benzene, (2-bromoethyl)-
  • Benzene,(2-bromoethyl)-
  • benzene,2-bromoethyl-
  • beta.-Phenylethylbromide
  • beta-Phenethyl bromide
  • beta-phenethylbromide
  • beta-Phenylethyl bromide
  • beta-phenylethylbromide
  • 2-Phenylethyl bromine
  • (2-Bromoethyl)benzene,98%
  • SS-BROMOETHYLBENZENE
  • (2-BROMOETHYL)BENZENESALMETEROL
  • β-Bromophenylethane
  • (2-BroMoethyl)benzene, 98% 100ML
  • Phenethyl Bromide 2-Phenylethyl Bromide
  • 2-PHENYLETHYL BROMIDE FOR SYNTHESIS
  • (2-Bromoethyl)benzene, 1-Bromo-2-phenylethane
  • Phenethyl bromide 98%
  • (2- Xiu Yiji)benzene
  • β- broMobenzene ethane
  • Beta broMine generation of ethyl benzene
  • 2-Phenylethyl bromide Phenethyl Bromide beta-Bromophenylethane
  • BROMOETHYLBENZENE(2-)
  • B-PHENYLETHYL BROMIDE
  • BETA-BROMOETHYL BENZENE
  • BETA-BROMOPHENYLETHANE
  • 2-PHENYLETHYL BROMIDE
  • -Bromoethylbenzene
  • (2-BROMOETHYL)BENZENE / PHENETHYL BROMIDE
  • (2-Bromoethyl)benzene
  • Tetrabomoethane
  • 2-PhenylethylBromide,>98%
  • 2-bromoethy benzene
  • Phenyl Ethyl Bromide / 2 – (Bromoethyl) Benzene
  • (2-Bromoethyl)benzene &gt
  • (2-Bromoethyl)benzene 2-Phenylethyl bromide CAS 103-63-9
  • (2-Bromoethyl)benzene cas 103-63-9
  • gbl (2-Bromoethyl)benzene
  • Benzene, (bromoethyl)-
  • β-BroMoethyl-benzene
  • 1-phenyl-2-bromoethane
  • Beta bromophenyletha
  • (2-Bromoethyl)benzene Basic information
  • CAS 103-63-9 with best priceFactory direct sale CAS NO.103-63-9
  • Β-PHENETHYL BROMIDE
  • (2-Bromoethyl)benzene ISO 9001：2015 REACH
  • 1-Brom-2-phenylethan
  • (2-Bromoethyl)benzene / 2-Phenylethyl bromide
  • best (2-Bromoethyl)benzene
  • Colorless Liquid (2-Bromoethyl) Benzene with Fast Delivery CAS 103-63-9