1-METHYL-1H-PYRAZOL-4-YLAMINE

Uses

Product Name: 1-METHYL-1H-PYRAZOL-4-YLAMINE
CAS No.: 69843-13-6
Chemical Name: 1-METHYL-1H-PYRAZOL-4-YLAMINE
Synonyms: 1-methyl-1H-pyrazol-4-amine hydrochloride;1-methylpyrazol-4-amine;1-Methyl-1H-pyrazole-4-ylaMine;AKOS B022860;AKOS PAO-0224;TIMTEC-BB SBB009607;ART-CHEM-BB B022860;4-Amino-1-methylpyrazole;ASINEX-REAG BAS 13529566;1-Methyl-4-amino-pyrazole
CBNumber: CB0432539
Molecular Formula: C4H7N3
Formula Weight: 97.12
MOL File: 69843-13-6.mol

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1-METHYL-1H-PYRAZOL-4-YLAMINE Property

Melting point:: 47-50℃
Density: 1.141 g/mL at 25 °C
refractive index: n20/D1.556
Flash point:: >110 °C
storage temp.: -20°C
pka: 3.70±0.10(Predicted)
form: liquid
color: Pale red
Sensitive: Air Sensitive
Boiling point:: 45-80°C/760 mmHg
InChI: InChI=1S/C4H7N3/c1-7-3-4(5)2-6-7/h2-3H,5H2,1H3
InChIKey: HEFHQCFTJGKPMD-UHFFFAOYSA-N
SMILES: N1(C)C=C(N)C=N1
CAS DataBase Reference: 69843-13-6

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Safety

Hazard Codes: Xi
Risk Statements: 36/38
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 772585
Product name: 4-Amino-1-methylpyrazole
Purity: 95%
Packaging: 1g
Price: $116
Updated: 2025/07/31

TRC

Product number: M320905
Product name: 1-Methyl-1H-pyrazol-4-amine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-1-B5
Product name: 4-Amino-1-methylpyrazole
Packaging: 5G
Price: $125
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-1-B5
Product name: 4-Amino-1-methylpyrazole
Packaging: 1g
Price: $75
Updated: 2021/12/16

Ark Pharm

Product number: P000723133
Product name: 1-Methyl-1H-pyrazol-4-amine
Purity: 98%
Packaging: 10g
Price: $48
Updated: 2021/12/16

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1-METHYL-1H-PYRAZOL-4-YLAMINE Chemical Properties,Usage,Production

Uses

1-Methyl-1H-pyrazole-4-amine is used as an organic and pharmaceutical intermediate.

Synthesis

3994-50-1

69843-13-6

1-Methyl-4-nitro-1H-pyrazole (1.62 g, 12.7 mmol) was used as the raw material, which was dissolved in methanol (250 mL) and hydrogenated on an H-Cube reactor at 60 bar hydrogen pressure and 70 °C to obtain 1-methyl-1H-pyrazol-4-amine (1.23 g, 99% yield). Subsequently, 1-methyl-1H-pyrazol-4-amine (700 mg, 7.0 mmol), 3-amino-6-bromopyridinecarboxylic acid (1.86 g, 8.5 mmol), PyBop (4.12 g, 8.0 mmol), dichloromethane (30 mL), and diisopropylethylamine (3.8 mL) were added to a 100 mL round-bottomed flask and the reaction mixture was stirred at room temperature for 24 h. The reaction progress was monitored by LCMS. Upon completion of the reaction, the solvent was removed by distillation and the crude product was purified by fast chromatography (eluent: heptane/ethyl acetate). A portion of the product was further purified by reversed-phase HPLC to afford the target compound 317.The product characterization data were as follows:1H NMR (400 MHz, DMSO) δ 10.25 (s, 1H), 8.03 (s, 1H), 7.70 (s, 1H), 7.43 (d, J = 8.7 Hz, 1H), 7.19 (d, J = 8.7 Hz, 1H), 7.02 (br, 2H), 3.81 (s, 3H); MS (ESI) m/z: 296.0/298.0 [M + H]+.

References

[1] Patent: US2011/251176, 2011, A1. Location in patent: Page/Page column 160-161
[2] Patent: WO2015/25197, 2015, A1. Location in patent: Paragraph 00077
[3] Patent: US2015/336982, 2015, A1. Location in patent: Paragraph 0179; 0181
[4] Patent: CN106432246, 2017, A. Location in patent: Paragraph 0453; 0806; 0807; 0808
[5] Patent: WO2015/161830, 2015, A1. Location in patent: Paragraph 00770

1-METHYL-1H-PYRAZOL-4-YLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-METHYL-1H-PYRAZOL-4-YLAMINE Suppliers

China 145 Finland 2 Germany 2 India 3 Russia 3 Ukraine 1 United Kingdom 3 United States 17 Global 176

Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd.

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View Lastest Price from 1-METHYL-1H-PYRAZOL-4-YLAMINE manufacturers

Career Henan Chemical Co

Product: 1-METHYL-1H-PYRAZOL-4-YLAMINE 69843-13-6
Price: US $8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-25

69843-13-6, 1-METHYL-1H-PYRAZOL-4-YLAMINERelated Search:

3-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-AMINE 1-ETHYL-5-METHYL-1H-PYRAZOL-4-YLAMINE 1,3-Dimethyl-1H-pyrazol-5-amine 1-METHYL-1H-PYRAZOL-5-YLAMINE N,1,3-TRIMETHYL-1H-PYRAZOL-5-AMINE 3-(4-Methoxyphenyl)-1-methyl-1H-pyrazol-5-amine 1,5-DIMETHYL-1 H-PYRAZOL-3-YLAMINE 4-(trifluoromethyl)-1H-pyrazol-5-amine 3-(4-Fluorophenyl)-1-methyl-1H-pyrazol-5-amine 1-METHYL-1H-PYRAZOL-3-YLAMINE 3-(2-Methoxyphenyl)-1-methyl-1H-pyrazol-5-amine 3-Amino-5-methylpyrazole 1H-PYRAZOL-4-YLAMINE 2-[4-(4-ISOPROPYL-BENZENESULFONYL)-PHENYL]-5-METHYL-2H-PYRAZOL-3-YLAMINE 1-(2,4-DICHLORO-BENZYL)-5-METHYL-1 H-PYRAZOL-3-YLAMINE 2-(1H-BENZOIMIDAZOL-2-YL)-5-METHYL-2H-PYRAZOL-3-YLAMINE 2-(2-DIMETHYLAMINO-ETHYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE 2-BENZOTHIAZOL-2-YL-5-METHYL-2H-PYRAZOL-3-YLAMINE

ART-CHEM-BB B022860

ASINEX-REAG BAS 13529566

1-METHYL-1H-PYRAZOL-4-YLAMINE

AKOS PAO-0224

AKOS B022860

TIMTEC-BB SBB009607

1-methyl-1H-pyrazol-4-amine hydrochloride

4-Amino-1-methylpyrazole

1-methyl-1H-pyrazol-4-amine(SALTDATA: 1.15HCl)

1-Methyl-4-amino-pyrazole

1-Methyl-1H-pyrazole-4-ylaMine

1-Methyl-4-AMinoMethy pyrazole

1-methylpyrazol-4-amine

1-methyl-1h-pyrazole-4-amine

1-Methyl-1H-pyrazol-4-amine 95%

1-Methyl-1H-pyrazol-4-ylamine .2Hcl

69843-13-6