3-(4-IODOPHENYL)PROPIONIC ACID
Uses- Product Name
- 3-(4-IODOPHENYL)PROPIONIC ACID
- CAS No.
- 1643-29-4
- Chemical Name
- 3-(4-IODOPHENYL)PROPIONIC ACID
- Synonyms
- 4-Iodohydrocinnamic acid;3-(4-Iodphenyl)propionsSre;4-Iodo-benzenepropanoic acid;3-(4-Iodphenyl)propionicacid;Benzenepropanoic acid, 4-iodo-;3-(4-IODOPHENYL)PROPIONIC ACID;3-(4-IODOPHENYL)PROPANOIC ACID
- CBNumber
- CB0433006
- Molecular Formula
- C9H9IO2
- Formula Weight
- 276.07
- MOL File
- 1643-29-4.mol
3-(4-IODOPHENYL)PROPIONIC ACID Property
- Melting point:
- 140-142°C
- Boiling point:
- 335.4±17.0 °C(Predicted)
- Density
- 1.775±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 4.61±0.10(Predicted)
- form
- solid
- color
- White to off-white
- CAS DataBase Reference
- 1643-29-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B448780
- Product name
- 3-(4-Iodophenyl)propanoicAcid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR6478
- Product name
- 3-(4-Iodophenyl)propanoicacid
- Packaging
- 250mg
- Price
- $24
- Updated
- 2021/12/16
- Product number
- 2721-H-X2
- Product name
- 3-(4-Iodophenyl)propanoic acid
- Packaging
- 250mg
- Price
- $26
- Updated
- 2021/12/16
- Product number
- OR6478
- Product name
- 3-(4-Iodophenyl)propanoicacid
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- 2721-H-X2
- Product name
- 3-(4-Iodophenyl)propanoic acid
- Packaging
- 1g
- Price
- $58
- Updated
- 2021/12/16
3-(4-IODOPHENYL)PROPIONIC ACID Chemical Properties,Usage,Production
Uses
p-Iodophenylpropionic acid is a carboxylic acid derivative and can be used as a biochemical reagent.
Synthesis
501-52-0
1643-29-4
The general procedure for the synthesis of 3-(4-iodophenyl)propionic acid from hydrogenated cinnamic acid is as follows: 1. Preparation of Intermediate 1: A mixture of H2SO4 (1.25 mL), water (12.5 mL) and AcOH (25 mL) was added to a 250 mL flask. Subsequently 3-phenylpropionic acid (3.00 g, 20.0 mmol), iodine (1.40 g, 5.5 mmol) and KIO3 (0.98 g, 4.6 mmol) were added. 2. the reaction mixture was heated to reflux and a solution of AcOH (25 mL) with iodine (1.40 g, 5.5 mmol) was added in portions, 5 mL at a time. the color of the solution gradually changed from purple to orange during the reaction. 3. After the reaction was carried out for 3 hours, when the color no longer changed, the reaction mixture was cooled to room temperature and the reaction was subsequently quenched with 1 M NaHSO3 solution. 4. Water was added to the reaction mixture and extracted with EtOAc. The organic phases were combined, washed with brine, dried over MgSO4 and concentrated in vacuum. 5. The crude product (4.15 g, 75% yield) containing a small amount of starting material and by-products was recrystallized by petroleum ether to give 1.83 g of pure white crystalline product (33% yield). Rf value: 0.10 (EtOAc:hexane, 1:4); 1H NMR (CDCl3) δ 7.62-7.59 (m, 2H), 6.97-6.95 (m, 2H), 2.92-2.87 (t, 2H, J = 7.5 Hz), 2.68-2.63 (t, 2H, J = 7.5 Hz); 13C NMR (CDCl3) δ 178.5, 139.7, 137.6, 130.4, 91.6, 35.2, 30.0.
References
[1] Patent: WO2010/12650, 2010, A1. Location in patent: Page/Page column 38
[2] Chemistry - A European Journal, 2009, vol. 15, # 10, p. 2278 - 2288
[3] Journal of the American Chemical Society, 2009, vol. 131, # 47, p. 17500 - 17521
[4] European Journal of Organic Chemistry, 2015, vol. 2015, # 27, p. 5919 - 5924
[5] Patent: WO2016/201125, 2016, A1. Location in patent: Page/Page column 19
3-(4-IODOPHENYL)PROPIONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(4-IODOPHENYL)PROPIONIC ACID manufacturers
- Product
- 3-(4-IODOPHENYL)PROPIONIC ACID 1643-29-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 3-(4-IODOPHENYL)PROPIONIC ACID 1643-29-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-12-19