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Boc-L-Tyr(tBu)-OH

Product Name
Boc-L-Tyr(tBu)-OH
CAS No.
47375-34-8
Chemical Name
Boc-L-Tyr(tBu)-OH
Synonyms
BOC-TYR(TBU)-OH;Boc-Tyr(tBu);BOC-L-TYR(TBU)-OH;BOC-TYR(BUT)-OH;Boc-Tyr(tBul)-OH;TIMTEC-BB SBB006926;BOC-TYROSINE(TBU)-OH;Boc-Tyr(tBu)-OH 100g;Boc-Tyr(tBu)-OH, 99.0%;BOC-O-T-BUTYL-L-TYROSINE
CBNumber
CB0434634
Molecular Formula
C18H27NO5
Formula Weight
337.41
MOL File
47375-34-8.mol
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Boc-L-Tyr(tBu)-OH Property

Melting point:
113-118 °C
alpha 
-15 º (C=1% IN DMF)
Boiling point:
484.0±40.0 °C(Predicted)
Density 
1.116±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
powder to crystal
pka
3.00±0.10(Predicted)
color 
White to Almost white
optical activity
[α]20/D 15.0±1.0°, c = 1% in DMF
Water Solubility 
Soluble in DMF. Insoluble in water.
BRN 
4327336
InChI
InChI=1S/C18H27NO5/c1-17(2,3)23-13-9-7-12(8-10-13)11-14(15(20)21)19-16(22)24-18(4,5)6/h7-10,14H,11H2,1-6H3,(H,19,22)(H,20,21)/t14-/m0/s1
InChIKey
ZEQLLMOXFVKKCN-AWEZNQCLSA-N
SMILES
C(O)(=O)[C@H](CC1=CC=C(OC(C)(C)C)C=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference
47375-34-8(CAS DataBase Reference)
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Safety

WGK Germany 
3
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53023
Product name
Boc-Tyr(tBu)-OH
Purity
Novabiochem?
Packaging
5G
Price
$199
Updated
2025/07/31
Sigma-Aldrich
Product number
8.53023
Product name
Boc-Tyr(tBu)-OH
Purity
Novabiochem?
Packaging
25g
Price
$785
Updated
2025/07/31
TCI Chemical
Product number
B3485
Product name
N-(tert-Butoxycarbonyl)-O-tert-butyl-L-tyrosine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$29
Updated
2025/07/31
TCI Chemical
Product number
B3485
Product name
N-(tert-Butoxycarbonyl)-O-tert-butyl-L-tyrosine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$86
Updated
2025/07/31
Sigma-Aldrich
Product number
15434
Product name
Boc-Tyr(tBu)-OH
Purity
≥99.0% (sum of enantiomers, TLC)
Packaging
5g
Price
$238
Updated
2025/07/31
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Boc-L-Tyr(tBu)-OH Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

N-Boc-O-tert-butyl-L-tyrosine (Boc-L-Tyr(tBu)-OH) is used as pharmaceutical intermediate.

Application

Boc-Tyr(tBu)-OH is an important organic reagent that can be used as a building block for the synthesis of many organic compounds. This compound could be used as a starting material to synthesize TPE-Tyr. TPE-Tyr can undergo covalent crosslinking via the formation of dityrosine linkages by exploiting horseradish peroxidase (HRP)-catalyzed phenol polymerization in the presence of H2O2, thereby activating the AIE process and switching on fluorescence emission of TPE core motif[1].

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

O-tert-butyl-L-tyrosine (2.00 g, 8.42 mmol, 1.0 equiv.) and di-tert-butyl dicarbonate (2.20 g, 10.10 mmol, 1.2 equiv.) were dissolved in a mixture of THF (15 mL) and NaOH (1 N, 30 mL) and stirred at room temperature for 10 h. THF was removed under reduced pressure, and the pH of residual solution was adjusted to 3.0 with dilute hydrochloric acid and the crude product was extracted by ethyl acetate. The combined organic phases was washed with saturated brine (pH 3.0) and dried over anhydrous Na2SO4. The organic solvent was removed under reduced pressure and dried in a vacuum oven at room temperature overnight, affording (N-Boc-O-tert-butyl)-L-Tyr (Boc-O-tert-butyl-L-tyrosine) as a yellowish solid (2.64 g, 93%)[1].

References

[1] Wang X, et al. Highly Selective Fluorogenic Multianalyte Biosensors Constructed via Enzyme-Catalyzed Coupling and Aggregation-Induced Emission. Journal of the American Chemical Society, 2014; 136: 9890–9893.

Boc-L-Tyr(tBu)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-L-Tyr(tBu)-OH Suppliers

Americas 1 China 215 Europe 3 Germany 5 India 4 Japan 3 Switzerland 2 United Kingdom 9 United States 30 Global 272
Chengdu Tachem Co., Ltd
Tel
19983060238
Email
sales@tachem.cn
Country
China
ProdList
103
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58
Shanghai Jifeng Biotechnology Co., Ltd.
Tel
021-61263377 15023907684
Fax
021-61263399
Email
15800684150@163.com
Country
China
ProdList
8131
Advantage
58
Shandong fen Boyu Biotechnology Co.,LTD
Tel
13356310019 13356310019;
Email
boyu2024@163.com
Country
China
ProdList
3247
Advantage
58
Sichuan HongRi Pharma-Tech Co., Ltd
Tel
02888457210; 18380436509
Fax
0838-2822568
Email
2065506070@qq.com
Country
China
ProdList
2025
Advantage
58
Chengdu ZY Biochemical Technology Co., Ltd.
Tel
88680086 13398185735
Email
fengzilong@zybiochem.com
Country
China
ProdList
177
Advantage
58
Tiantai Yisheng Biochemical Technology Co., Ltd
Tel
0576-83869808 18958639818
Email
156697457@qq.com
Country
China
ProdList
84
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Sichuan Tongsheng Amino acids Co.,Ltd.
Tel
0838-2274206 13908101207
Fax
+86-838-2274207
Email
sales@biots.cn
Country
China
ProdList
279
Advantage
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View Lastest Price from Boc-L-Tyr(tBu)-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-L-Tyr(tBu)-OH 47375-34-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-09-27
Zhuozhou Wenxi import and Export Co., Ltd
Product
Boc-O-tert-butyl-L-tyrosine 47375-34-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
Boc-O-tert-butyl-L-tyrosine 47375-34-8
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
500KG
Release date
2018-08-19

47375-34-8, Boc-L-Tyr(tBu)-OHRelated Search:

tert-Butanol tert-Butyl hydroperoxide tert-Butyl methyl ether BUTYL OLEATE 4-tert-Butylcatechol L-Tyrosine Cyhalofop-butyl 4-tert-Butylphenol Boc-Aib-OH Boc-D-Tyr-OH tert-Butyldimethylsilyl chloride Buprofezin Methyl 4-tert-butylbenzoate TYROSINASE Dibutyl phthalate BOC-GLY-LEU-OH Boc-Tyr(Me)-OH O-METHYL-D-TYROSINE

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