1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID
- Product Name
- 1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID
- CAS No.
- 181955-79-3
- Chemical Name
- 1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID
- Synonyms
- 1,4-Bis(N-boc)piperazine-2-carboxylicaci;1,4-Bis(Boc)-2-piperazinecarboxylic Acid;1,4-bis-Boc-piperazine-2-carboxylic acid;1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID;1,4-Di-Boc-piperazine-2-carboxylic acid 97%;1-N-Boc-4-N-Boc-piperazine-2-carboxylic acid;1,4-DI-BOC-PIPERAZINE-2-(+/-)-CARBOXYLIC ACID;1,4-Di-Boc-piperazine-2-carboxylic acid, 97.5%;Piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester;1,2,4-Piperazinetricarboxylic acid 1,4-bis(tert-butyl) ester
- CBNumber
- CB0443847
- Molecular Formula
- C15H26N2O6
- Formula Weight
- 330.38
- MOL File
- 181955-79-3.mol
1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID Property
- Melting point:
- 142-148°C
- Boiling point:
- 443.9±40.0 °C(Predicted)
- Density
- 1.200±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.70±0.20(Predicted)
- form
- solid
- Appearance
- White to off-white Solid
- InChIKey
- IIZGWFQKLVCLLA-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 756350
- Product name
- 1,4-Di-Boc-piperazine-2-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $253.65
- Updated
- 2025/07/31
- Product number
- D422810
- Product name
- 1,4-Di-Boc-piperazine-2-carboxylic acid
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- D422810
- Product name
- 1,4-Di-Boc-piperazine-2-carboxylic acid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB147579
- Product name
- 1,4-Bis(N-boc)piperazine-2-carboxylicacid
- Packaging
- 250mg
- Price
- $72.5
- Updated
- 2021/12/16
- Product number
- W3950
- Product name
- 1,4-Di-Boc-piperazine-2-carboxylic acid
- Packaging
- 5g
- Price
- $242
- Updated
- 2021/12/16
1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Chemical Properties
White powder
Synthesis
2762-32-5
24424-99-5
181955-79-3
General procedure for the synthesis of 1,4-bis-BOC-2-piperazinecarboxylic acid from 2-piperazinecarboxylic acid and di-tert-butyl dicarbonate: In a 1 L round bottom flask, 15.76 g NaOH (394 mmol) was dissolved in 390 mL of water, followed by the addition of 20 g of 2-piperazinecarboxylic acid (98 mmol) in batches to obtain a colorless solution. A solution of 50 mL of Boc2O (215 mmol) dissolved in 1,4-dioxane was added slowly and dropwise while the temperature was maintained below +5 °C. Upon completion of the reaction, the mixture was cooled to +5 °C and the pH was subsequently adjusted to 3 with 3N HCl. The suspension was extracted with 300 mL of ethyl acetate (AcOEt), the organic phases were combined and dried over sodium sulfate. After vacuum evaporation, 22.7 g of white solid product was obtained. The aqueous phase was acidified with 3N HCl to pH=3 and then extracted with 2×100mL ethyl acetate (AcOEt), and the organic phases were similarly dried with sodium sulfate and then vacuum evaporated to give a second batch of 7.9g of product. The two batches of product were combined to give the final 1,4-bis-BOC-2-piperazinecarboxylic acid (30.6 g, 94% yield). The product was confirmed by 1H-NMR (400 MHz, DMSO-d6): δ 1.33 (18H, m), 2.70-4.50 (8H, m), 12.9 (1H, s); the mass spectrum (ES) showed m/z 330 [M+H]+.
References
[1] Patent: WO2008/148853, 2008, A1. Location in patent: Page/Page column 157-158
[2] Patent: US2014/288045, 2014, A1. Location in patent: Paragraph 0531
[3] Angewandte Chemie - International Edition, 2018,
[4] Angew. Chem., 2018, vol. 130, # 44, p. 14768 - 14773,6
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 23, p. 4241 - 4244
1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID manufacturers
- Product
- 1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID 181955-79-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98.0%
- Supply Ability
- 10000kg
- Release date
- 2023-03-29