4-(Trifluoromethoxy)benzyl bromide
Uses- Product Name
- 4-(Trifluoromethoxy)benzyl bromide
- CAS No.
- 50824-05-0
- Chemical Name
- 4-(Trifluoromethoxy)benzyl bromide
- Synonyms
- 1-(BROMOMETHYL)-4-(TRIFLUOROMETHOXY)BENZENE;TIMTEC-BB SBB006578;Pretomanid Impurity 4;4-(Trifluoromethoxy)benzyl;TrifluoroMethoxy BroMobenzyl;4-trifluoromethoxybromobenzyl;P-TritluromethoxybenzylBromide;4-trifluoromethoxylbenzylbromide;4-(TRIFLUOROMETHOXY)BENZYL BROMIDE;4-(Trifluoromethyloxy）benzylbromide
- CBNumber
- CB0452065
- Molecular Formula
- C8H6BrF3O
- Formula Weight
- 255.03
- MOL File
- 50824-05-0.mol
4-(Trifluoromethoxy)benzyl bromide Property
- Melting point:
- 22-24°C
- Boiling point:
- 82-84 °C10 mm Hg(lit.)
- Density
- 1.594 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.48(lit.)
- Flash point:
- 202 °F
- storage temp.
- Refrigerated.
- solubility
- soluble in Chloroform, Methanol
- form
- Liquid or Low Melting Solid
- Specific Gravity
- 1.594
- color
- Clear faintly yellow
- Sensitive
- Lachrymatory
- BRN
- 2521451
- InChI
- InChI=1S/C8H6BrF3O/c9-5-6-1-3-7(4-2-6)13-8(10,11)12/h1-4H,5H2
- InChIKey
- JDNPUJCKXLOHOW-UHFFFAOYSA-N
- SMILES
- C1(CBr)=CC=C(OC(F)(F)F)C=C1
- CAS DataBase Reference
- 50824-05-0(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-27-28-36/37/39-45
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- Hazard Note
- Corrosive/Lachrymatory
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29093090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 370622
- Product name
- 4-(Trifluoromethoxy)benzyl bromide
- Purity
- 97%
- Packaging
- 1g
- Price
- $82.55
- Updated
- 2025/07/31
- Product number
- 370622
- Product name
- 4-(Trifluoromethoxy)benzyl bromide
- Purity
- 97%
- Packaging
- 5g
- Price
- $131.1
- Updated
- 2025/07/31
- Product number
- T1781
- Product name
- 4-(Trifluoromethoxy)benzyl Bromide
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- T1781
- Product name
- 4-(Trifluoromethoxy)benzyl Bromide
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $102
- Updated
- 2025/07/31
- Product number
- T774440
- Product name
- 4-(Trifluoromethoxy)benzyl Bromide
- Packaging
- 25g
- Price
- $350
- Updated
- 2021/12/16
4-(Trifluoromethoxy)benzyl bromide Chemical Properties,Usage,Production
Uses
4-Trifluoromethoxybenzyl Bromide is a useful synthetic intermediate. It is used to prepare (nitro)[(trifluoromethoxy)benzyloxy]dihydroimidazo[2,1-b][1,3]oxazines with antitubercular activities. It is also used to synthesize tetrahydronaphthalenols with anti-allergic activities.
Chemical Properties
Colorless to light yellow liqui
Uses
4-(Trifluoromethoxy)benzyl bromide may be used in the synthesis of bioreductive drug, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
General Description
Polymerizations of 4-(trifluoromethoxy)benzyl bromide, via Friedel-Crafts polymerization using aluminum chloride as a catalyst has been reported.
Synthesis
1736-74-9
50824-05-0
Synthesis of 1-(bromomethyl)-4-(trifluoromethoxy)benzene: Phosphorus tribromide (6 g, 22.2 mmol) was slowly added dropwise to a solution of (4-(trifluoromethoxy)phenyl)methanol (3.6 g, 18.8 mmol) in dichloromethane (60 mL) at 0-10 °C and stirred for 30 min. The reaction mixture was then continued to stir at room temperature for 3 hours. Upon completion of the reaction, the reaction was terminated by the addition of water (30 mL) and the mixture was washed sequentially with aqueous sodium bicarbonate (2 x 30 mL) and brine (30 mL). The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 4-trifluoromethoxybenzyl bromide (3.5 g, 66% yield) as a yellow oil.
References
[1] Patent: US2007/270434, 2007, A1. Location in patent: Page/Page column 17
[2] J. Gen. Chem. USSR (Engl. Transl.), 1965, vol. 35, p. 1631 - 1637
[3] Zhurnal Obshchei Khimii, 1965, vol. 35, p. 1628 - 1636
[4] Journal of Medicinal Chemistry, 2005, vol. 48, # 2, p. 556 - 568
[5] Organometallics, 2014, vol. 33, # 21, p. 5940 - 5943
4-(Trifluoromethoxy)benzyl bromide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(Trifluoromethoxy)benzyl bromide manufacturers
- Product
- 4-(Trifluoromethoxy)benzyl bromide 50824-05-0
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-04
- Product
- 4-(Trifluoromethoxy)benzyl bromide 50824-05-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- 4-(Trifluoromethoxy)benzyl bromide 50824-05-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2020-01-16