7-METHYL (1H)INDAZOLE

Product Name: 7-METHYL (1H)INDAZOLE
CAS No.: 3176-66-7
Chemical Name: 7-METHYL (1H)INDAZOLE
Synonyms: 7-Methylindazole;7-Methyl-1H-indazol;7-METHYL (1H)INDAZOLE;1H-Indazole, 7-methyl-;7-methyl-1H-indazole(SALTDATA: FREE)
CBNumber: CB0453370
Molecular Formula: C8H8N2
Formula Weight: 132.16
MOL File: 3176-66-7.mol

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7-METHYL (1H)INDAZOLE Property

Melting point:: 158 °C
Boiling point:: 285.1±9.0 °C(Predicted)
Density: 1.186±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder
pka: 14.39±0.40(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C8H8N2/c1-6-3-2-4-7-5-9-10-8(6)7/h2-5H,1H3,(H,9,10)
InChIKey: RLAZPAQEVQDPHR-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC=C2C)C=N1

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CBR00226
Product name: 7-Methyl-1H-indazole
Purity: Aldrich
Packaging: 1g
Price: $179
Updated: 2025/07/31

TRC

Product number: M313440
Product name: 7-Methyl-1H-indazole
Packaging: 1g
Price: $195
Updated: 2021/12/16

TRC

Product number: M313440
Product name: 7-Methyl-1H-indazole
Packaging: 2.5g
Price: $275
Updated: 2021/12/16

Apolloscientific

Product number: OR928851
Product name: 7-Methyl-1H-indazole
Purity: 98%
Packaging: 5g
Price: $355
Updated: 2021/12/16

Matrix Scientific

Product number: 037675
Product name: 7-Methyl-1H-indazole
Packaging: 500mg
Price: $62
Updated: 2021/12/16

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7-METHYL (1H)INDAZOLE Chemical Properties,Usage,Production

Uses

7-Methyl-1H-indazole, can be used for the synthesis of 2-[(Heteroaryl)methyl]imidazolines, having activities at α1- and α2-adrenoceptors.

Synthesis

87-62-7

3176-66-7

General procedure for the synthesis of 7-methyl-1H-indazole from 2,6-dimethylaniline: tert-butyl nitrite (52 mL) was slowly added to a solution of chloroform (750 mL) of 2,6-dimethylaniline (25 g, 206 mmol) at room temperature and protected by nitrogen, stirred for 20 min, then potassium acetate (40 g, 412 mmol) and 18-crown-6 ( 5.4 g, 20.6 mmol). The reaction mixture was heated to reflux for 3 hours, followed by cooling to room temperature and continued stirring for 15 hours. Upon completion of the reaction, the solids in the mixture were removed by vacuum filtration and the solids were washed with chloroform (400 mL). The filtrates were combined, washed with water (2 x 250 mL), dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The residue was purified by fast column chromatography on silica gel, using hexane/ethyl acetate (9:1) as eluent to afford 7-methyl-1H-indazole as an orange solid (23 g, 85% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 2.60 (s, 3H), 7.10 (m, 2H), 7.70 (d, 1H), 8.10 (s, 1H).

References

[1] Patent: WO2005/66136, 2005, A1. Location in patent: Page/Page column 108-109
[2] Liebigs Annalen der Chemie, 1980, # 6, p. 908 - 927
[3] ChemMedChem, 2017, vol. 12, # 3, p. 257 - 270

7-METHYL (1H)INDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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7-METHYL (1H)INDAZOLE Suppliers

China 89 Germany 1 India 3 The Netherlands 1 United Kingdom 2 United States 11 Global 107

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View Lastest Price from 7-METHYL (1H)INDAZOLE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 7-METHYL (1H)INDAZOLE 3176-66-7
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-08

Career Henan Chemical Co

Product: 7-METHYL (1H)INDAZOLE 3176-66-7
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-04

3176-66-7, 7-METHYL (1H)INDAZOLERelated Search:

Pigment Red 195 7-METHYL (1H)INDAZOLE Vat Black 8 5-BROMO-7-METHYL-1H-INDAZOLE 3-METHYL-1H-INDAZOLE 3-Methyl-6-nitroindazole 3-(PHENYLMETHYL)-1H-INDAZOLE 6-BROMO-1-METHYL-1H-INDAZOLE 7-BROMO-1-METHYL-1H-INDAZOLE 7-BROMO-2-METHYL-2H-INDAZOLE (5-Chloro-1H-indazol-3-yl)-methanol ,97% 6-Chloro-1-methyl-1H-indazole 4-Iodo-2-methyl-2H-indazole 5-Fluoro-2-methyl-2H-indazole 5-METHYL-1H-INDAZOLE-3-CARBONITRILE 4-Fluoro-1-methylindazole 5-BROMO-1-METHYL-1H-INDAZOLE 4-BROMO-2-METHYL-2H-INDAZOLE

7-METHYL (1H)INDAZOLE

7-Methylindazole

1H-Indazole, 7-methyl-

7-methyl-1H-indazole(SALTDATA: FREE)

7-Methyl-1H-indazol

3176-66-7

pharmacetical