ChemicalBook > CAS DataBase List > 7-METHYL (1H)INDAZOLE
7-METHYL (1H)INDAZOLE
- Product Name
- 7-METHYL (1H)INDAZOLE
- CAS No.
- 3176-66-7
- Chemical Name
- 7-METHYL (1H)INDAZOLE
- Synonyms
- 7-Methylindazole;7-Methyl-1H-indazol;7-METHYL (1H)INDAZOLE;1H-Indazole, 7-methyl-;7-methyl-1H-indazole(SALTDATA: FREE)
- CBNumber
- CB0453370
- Molecular Formula
- C8H8N2
- Formula Weight
- 132.16
- MOL File
- 3176-66-7.mol
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7-METHYL (1H)INDAZOLE Property
- Melting point:
- 158 °C
- Boiling point:
- 285.1±9.0 °C(Predicted)
- Density
- 1.186±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder
- pka
- 14.39±0.40(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C8H8N2/c1-6-3-2-4-7-5-9-10-8(6)7/h2-5H,1H3,(H,9,10)
- InChIKey
- RLAZPAQEVQDPHR-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2C)C=N1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- CBR00226
- Product name
- 7-Methyl-1H-indazole
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $179
- Updated
- 2025/07/31
TRC
- Product number
- M313440
- Product name
- 7-Methyl-1H-indazole
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
TRC
- Product number
- M313440
- Product name
- 7-Methyl-1H-indazole
- Packaging
- 2.5g
- Price
- $275
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR928851
- Product name
- 7-Methyl-1H-indazole
- Purity
- 98%
- Packaging
- 5g
- Price
- $355
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 037675
- Product name
- 7-Methyl-1H-indazole
- Packaging
- 500mg
- Price
- $62
- Updated
- 2021/12/16
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7-METHYL (1H)INDAZOLE Chemical Properties,Usage,Production
Uses
7-Methyl-1H-indazole, can be used for the synthesis of 2-[(Heteroaryl)methyl]imidazolines, having activities at α1- and α2-adrenoceptors.
Synthesis
87-62-7
3176-66-7
General procedure for the synthesis of 7-methyl-1H-indazole from 2,6-dimethylaniline: tert-butyl nitrite (52 mL) was slowly added to a solution of chloroform (750 mL) of 2,6-dimethylaniline (25 g, 206 mmol) at room temperature and protected by nitrogen, stirred for 20 min, then potassium acetate (40 g, 412 mmol) and 18-crown-6 ( 5.4 g, 20.6 mmol). The reaction mixture was heated to reflux for 3 hours, followed by cooling to room temperature and continued stirring for 15 hours. Upon completion of the reaction, the solids in the mixture were removed by vacuum filtration and the solids were washed with chloroform (400 mL). The filtrates were combined, washed with water (2 x 250 mL), dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The residue was purified by fast column chromatography on silica gel, using hexane/ethyl acetate (9:1) as eluent to afford 7-methyl-1H-indazole as an orange solid (23 g, 85% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 2.60 (s, 3H), 7.10 (m, 2H), 7.70 (d, 1H), 8.10 (s, 1H).
References
[1] Patent: WO2005/66136, 2005, A1. Location in patent: Page/Page column 108-109
[2] Liebigs Annalen der Chemie, 1980, # 6, p. 908 - 927
[3] ChemMedChem, 2017, vol. 12, # 3, p. 257 - 270
7-METHYL (1H)INDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-METHYL (1H)INDAZOLE manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- 7-METHYL (1H)INDAZOLE 3176-66-7
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-08
Career Henan Chemical Co
- Product
- 7-METHYL (1H)INDAZOLE 3176-66-7
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04
3176-66-7, 7-METHYL (1H)INDAZOLERelated Search:
Pigment Red 195
7-METHYL (1H)INDAZOLE
Vat Black 8
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7-BROMO-2-METHYL-2H-INDAZOLE
(5-Chloro-1H-indazol-3-yl)-methanol ,97%
6-Chloro-1-methyl-1H-indazole
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