O-Phospho-L-serine
- Product Name
- O-Phospho-L-serine
- CAS No.
- 407-41-0
- Chemical Name
- O-Phospho-L-serine
- Synonyms
- L O;P-ser;L-SOP;L-O-(RG);Seriphos;P-serine;Fosforina;3-P-SERINE;Phospho Ser;Phospho?Ser
- CBNumber
- CB0456205
- Molecular Formula
- C3H8NO6P
- Formula Weight
- 185.07
- MOL File
- 407-41-0.mol
O-Phospho-L-serine Property
- Melting point:
- 190 °C(lit.)
- alpha
- [α]D20 +14～+18°(c=5,dil.HCl)
- Boiling point:
- 475.4±55.0 °C(Predicted)
- Density
- 1.809±0.06 g/cm3(Predicted)
- vapor pressure
- 0Pa at 20℃
- storage temp.
- under inert gas
- solubility
- H2O: 50 mg/mL hot, clear, colorless to slightly yellow
- form
- Crystalline Powder
- pka
- pK1:2.08;pK2:5.65;pK3:9.74 (25°C)
- color
- White
- biological source
- mouse
- optical activity
- +16.221 (2 mol dm-3 HCl)
- Water Solubility
- 28.34g/L at 20℃
- Merck
- 14,7363
- BRN
- 1726826
- InChIKey
- BZQFBWGGLXLEPQ-UWTATZPHSA-N
- CAS DataBase Reference
- 407-41-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P0878
- Product name
- O-Phospho-L-serine
- Packaging
- 1g
- Price
- $33.6
- Updated
- 2025/07/31
- Product number
- P3430
- Product name
- Monoclonal Anti-Phosphoserine antibody produced in mouse
- Purity
- clone PSR-45, ascites fluid
- Packaging
- 100μL
- Price
- $536
- Updated
- 2025/07/31
- Product number
- P3430
- Product name
- Monoclonal Anti-Phosphoserine antibody produced in mouse
- Purity
- clone PSR-45, ascites fluid
- Packaging
- 0.2mL
- Price
- $732
- Updated
- 2025/07/31
- Product number
- 72983
- Product name
- O-Phospho-L-serine
- Purity
- certified reference material, TraceCERT
- Packaging
- 100mg
- Price
- $185
- Updated
- 2025/07/31
- Product number
- 5.09705
- Product name
- L-Serine-O-phosphate - CAS 407-41-0 - Calbiochem
- Packaging
- 1g
- Price
- $63.1
- Updated
- 2022/05/15
O-Phospho-L-serine Chemical Properties,Usage,Production
Description
O-
Chemical Properties
White powder
Uses
roborant
Uses
O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.
Uses
L-O-Phosphoserine is the catalytic domain of human protein kinase C β II when complexed with a malemide inhibitor. It is also used in the purification of the Epstein-Barr virus nuclear antigen 2A.
Definition
ChEBI: O-phospho-L-serine is the L-enantiomer of O-phosphoserine. It has a role as an EC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitor, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, an EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitor, an EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor and a mouse metabolite. It is a conjugate acid of an O-phosphonato-L-serine(2-). It is an enantiomer of an O-phospho-D-serine.
General Description
Monoclonal Anti-Phosphoserine (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
Flammability and Explosibility
Not classified
Biological Activity
Group III metabotropic glutamate receptor agonist; analog of L-AP4 (L-(+)-2-Amino-4-phosphonobutyric acid ). Inhibits proliferation and enhances neuronal differentiation in progenitor cells.
Biochem/physiol Actions
Protein phosphorylation and dephosphorylation are basic signaling mechanisms that modify protein function in eukaryotic cells. Phosphorylation is a rare posttranslational event in normal tissues, however, the abundance of phosphorylated cellular proteins increases several folds following various activation processes. The main amino acids that are phosphorylated are tyrosine, serine, or threonine (pTyr/pSer/pThr), each having specific kinases that phosphorylate them and specific phosphatases that dephosphorylate them. Mono and polyclonal antibodies directed against phosphorylated residues were generated and found useful as analytical and preparative tools by enabling the identification, quantification, and immunoaffinity isolation of phosphorylated cellular proteins.
storage
Room temperature
Purification Methods
Recrystallise the phospho-serine by dissolving 10g in H2O (150mL) at 25o, stirring for up to 20minutes. Undissolved material is filtered off (Büchner), and 95% EtOH (85mL) is added dropwise during 4minutes, and set aside at 25o for 3hours, then at 3o overnight. The crystals are washed with 95% EtOH (100mL), then dry Et2O (50mL), and dried in a vacuum (yield 6.5g). A further quantity (1.5g) can be obtained by keeping the mother liquors and washings at -10o for 1 week. The DL-isomer has m 167-170o(dec) after recrystallisation from H2O/EtOH or MeOH. [Neuhaus & Korkes Biochemical Preparations 6 75 1958, Neuhaus & Byrne J Biol Chem 234 113 1959, IR: F.lsch & Mellander Acta Chem Scand 11 1232 1957, Beilstein 4 IV 3120.]
References
[1] L ERIKSEN C T. [3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a.[J]. British Journal of Pharmacology, 1995, 116 8: 3279-3287. DOI: 10.1111/j.1476-5381.1995.tb15136.x
[2] P J CONN J P P. Pharmacology and functions of metabotropic glutamate receptors.[J]. Annual review of pharmacology and toxicology, 1997, 37: 205-237. DOI: 10.1146/annurev.pharmtox.37.1.205
[3] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[4] TRAVIS J. BAILEY. The inhibitor of phagocytosis, O-phospho-l-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina[J]. Experimental eye research, 2010, 91 5: Pages 601-612. DOI: 10.1016/j.exer.2010.07.017
[5] JONATHAN P SAXE. A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation.[J]. Chemistry & biology, 2007, 14 9: 1019-1030. DOI: 10.1016/j.chembiol.2007.07.016
O-Phospho-L-serine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from O-Phospho-L-serine manufacturers
- Product
- O-Phospho-L-serine 407-41-0
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1000kg
- Release date
- 2021-12-08
- Product
- O-Phospho-L-serine 407-41-0
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-08-08
- Product
- O-Phospho-L-serine 407-41-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-19