D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL-
- Product Name
- D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL-
- CAS No.
- 119567-63-4
- Chemical Name
- D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL-
- Synonyms
- DIMETHYLSPHINGOSINE;N-Dimethylsphingosine;N,N-dimethylsphingenine;N,N-DIMETHYLSPHINGOSINE;SPHINGOSINE, N,N-DIMETHYL;DIMETHYL SPHINGOSINE (D18:1);Dimethyl-D-erythro-sphingosine;N,N-Dimethylsphingosine (d18:1);D-ERYTHRO-N,N-DIMETHYLSPHINGOSINE;N,N-DIMETHYLSPHINGOSINE, D-ERYTHRO
- CBNumber
- CB0456649
- Molecular Formula
- C20H41NO2
- Formula Weight
- 327.55
- MOL File
- 119567-63-4.mol
D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- Property
- Boiling point:
- 447.2±45.0 °C(Predicted)
- Density
- 0.921±0.06 g/cm3(Predicted)
- Flash point:
- 14 °C
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
- pka
- 13.72±0.20(Predicted)
- form
- Waxy solid/Clear oil
- color
- colorless
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- CAS DataBase Reference
- 119567-63-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H350May cause cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P308+P313IF exposed or concerned: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML0311
- Product name
- N,N-Dimethylsphingosine
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 310500
- Product name
- N,N-Dimethylsphingosine
- Packaging
- 5mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 62575
- Product name
- N,N-Dimethylsphingosine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 62575
- Product name
- N,N-Dimethylsphingosine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $131
- Updated
- 2024/03/01
- Product number
- SML0311
- Product name
- N,N-Dimethylsphingosine
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $442
- Updated
- 2024/03/01
D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- Chemical Properties,Usage,Production
Description
N,N-Dimethylsphingosine (119567-63-4) is a synthetic derivative of D-erythro-sphingosine (Cat.# 10-2287). Endogenous sphingolipid.1?Inhibits sphingosine kinase (IC50 = 5 μM).2?N,N-Dimethylsphingosine induces apoptosis in a variety of cell lines.3
Chemical Properties
Colourless to Light Yellow Oil
Uses
D-erythro-N,N-Dimethylsphingosine is general modulator of protein kinases . D-erythro-N,N-Dimethylsphingosine is implicated in neuropathic pain.
Uses
N,N-Dimethylsphingosine is an inhibitor of sphingosine kinase (SPHK). It is a natural metabolite of sphingosine in some cancer cell lines and tissues. N,N-Dimethylsphingosine inhibited U937 cell SPHK with a Ki value of 3.1 μM. N,N-Dimethylsphingosine induces apoptosis, but it is not an inhibitor of protein kinase C.
Uses
A general modulator of protein kinases.
Definition
ChEBI: N,N-dimethylsphingosine is a sphingoid that is sphingosine in which the two amino hydrogens are replaced by methyl groups. It has a role as a metabolite and an EC 2.7.1.91 (sphingosine kinase) inhibitor. It is an aminodiol, a sphingoid and a tertiary amino compound. It is functionally related to a sphingosine. It is a conjugate base of a N,N-dimethylsphingosine(1+).
General Description
Dimethyl Sphingosine (d18:1), also called as N,N-Dimethyl-d-erythro-sphingosine (DMS), is a natural sphingolipid metabolite. It is found in various tissues.
Biochem/physiol Actions
N,N-Dimethylsphingosine (DMS) is an endogenous metabolite of sphingosine produced in various tissues and tumor cell lines. N,N-Dimethylsphingosine is a potent inhbitor of sphingosine kinase. DMS levels are elevated in the spinal cord, and contributes to allodynia, in a transected-nerve model of neuropathic pain.
References
1) Igarashi et al. (1990), A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells; J. Biol. Chem., 265 5385 2) Yatomi et al. (1996), N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets; Biochemistry, 35 626 3) Gude et al. (2008), Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal; FASEB J., 22 2629
D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- manufacturers
- Product
- D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- 119567-63-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11