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D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL-

Product Name
D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL-
CAS No.
119567-63-4
Chemical Name
D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL-
Synonyms
DIMETHYLSPHINGOSINE;N-Dimethylsphingosine;N,N-dimethylsphingenine;N,N-DIMETHYLSPHINGOSINE;SPHINGOSINE, N,N-DIMETHYL;DIMETHYL SPHINGOSINE (D18:1);Dimethyl-D-erythro-sphingosine;N,N-Dimethylsphingosine (d18:1);D-ERYTHRO-N,N-DIMETHYLSPHINGOSINE;N,N-DIMETHYLSPHINGOSINE, D-ERYTHRO
CBNumber
CB0456649
Molecular Formula
C20H41NO2
Formula Weight
327.55
MOL File
119567-63-4.mol
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D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- Property

Boiling point:
447.2±45.0 °C(Predicted)
Density 
0.921±0.06 g/cm3(Predicted)
Flash point:
14 °C
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
pka
13.72±0.20(Predicted)
form 
Waxy solid/Clear oil
color 
colorless
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
CAS DataBase Reference
119567-63-4(CAS DataBase Reference)
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Safety

Hazard Codes 
F
Risk Statements 
11
Safety Statements 
7-16
RIDADR 
UN 1170 3/PG 2
WGK Germany 
1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P308+P313IF exposed or concerned: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0311
Product name
N,N-Dimethylsphingosine
Purity
≥98% (HPLC)
Packaging
5mg
Price
$110
Updated
2024/03/01
Sigma-Aldrich
Product number
310500
Product name
N,N-Dimethylsphingosine
Packaging
5mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
62575
Product name
N,N-Dimethylsphingosine
Purity
≥98%
Packaging
5mg
Price
$70
Updated
2024/03/01
Cayman Chemical
Product number
62575
Product name
N,N-Dimethylsphingosine
Purity
≥98%
Packaging
10mg
Price
$131
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0311
Product name
N,N-Dimethylsphingosine
Purity
≥98% (HPLC)
Packaging
25mg
Price
$442
Updated
2024/03/01
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D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- Chemical Properties,Usage,Production

Description

N,N-Dimethylsphingosine (119567-63-4) is a synthetic derivative of D-erythro-sphingosine (Cat.# 10-2287). Endogenous sphingolipid.1?Inhibits sphingosine kinase (IC50 = 5 μM).2?N,N-Dimethylsphingosine induces apoptosis in a variety of cell lines.3

Chemical Properties

Colourless to Light Yellow Oil

Uses

D-erythro-N,N-Dimethylsphingosine is general modulator of protein kinases . D-erythro-N,N-Dimethylsphingosine is implicated in neuropathic pain.

Uses

N,N-Dimethylsphingosine is an inhibitor of sphingosine kinase (SPHK). It is a natural metabolite of sphingosine in some cancer cell lines and tissues. N,N-Dimethylsphingosine inhibited U937 cell SPHK with a Ki value of 3.1 μM. N,N-Dimethylsphingosine induces apoptosis, but it is not an inhibitor of protein kinase C.

Uses

A general modulator of protein kinases.

Definition

ChEBI: N,N-dimethylsphingosine is a sphingoid that is sphingosine in which the two amino hydrogens are replaced by methyl groups. It has a role as a metabolite and an EC 2.7.1.91 (sphingosine kinase) inhibitor. It is an aminodiol, a sphingoid and a tertiary amino compound. It is functionally related to a sphingosine. It is a conjugate base of a N,N-dimethylsphingosine(1+).

General Description

Dimethyl Sphingosine (d18:1), also called as N,N-Dimethyl-d-erythro-sphingosine (DMS), is a natural sphingolipid metabolite. It is found in various tissues.

Biochem/physiol Actions

N,N-Dimethylsphingosine (DMS) is an endogenous metabolite of sphingosine produced in various tissues and tumor cell lines. N,N-Dimethylsphingosine is a potent inhbitor of sphingosine kinase. DMS levels are elevated in the spinal cord, and contributes to allodynia, in a transected-nerve model of neuropathic pain.

References

1) Igarashi et al. (1990), A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells; J. Biol. Chem., 265 5385 2) Yatomi et al. (1996), N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets; Biochemistry, 35 626 3) Gude et al. (2008), Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal; FASEB J., 22 2629

D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- Preparation Products And Raw materials

Raw materials

Preparation Products

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D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- Suppliers

J & K SCIENTIFIC LTD.
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View Lastest Price from D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- 119567-63-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

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