D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL-

Product Name: D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL-
CAS No.: 119567-63-4
Chemical Name: D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL-
Synonyms: DIMETHYLSPHINGOSINE;N-Dimethylsphingosine;N,N-dimethylsphingenine;N,N-DIMETHYLSPHINGOSINE;SPHINGOSINE, N,N-DIMETHYL;DIMETHYL SPHINGOSINE (D18:1);Dimethyl-D-erythro-sphingosine;N,N-Dimethylsphingosine (d18:1);D-ERYTHRO-N,N-DIMETHYLSPHINGOSINE;N,N-DIMETHYLSPHINGOSINE, D-ERYTHRO
CBNumber: CB0456649
Molecular Formula: C20H41NO2
Formula Weight: 327.55
MOL File: 119567-63-4.mol

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D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- Property

Boiling point:: 447.2±45.0 °C(Predicted)
Density: 0.921±0.06 g/cm3(Predicted)
Flash point:: 14 °C
storage temp.: -20°C
solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
pka: 13.72±0.20(Predicted)
form: Waxy solid/Clear oil
color: colorless
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
CAS DataBase Reference: 119567-63-4(CAS DataBase Reference)

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Safety

Hazard Codes: F
Risk Statements: 11
Safety Statements: 7-16
RIDADR: UN 1170 3/PG 2
WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P308+P313IF exposed or concerned: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0311
Product name: N,N-Dimethylsphingosine
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $110
Updated: 2024/03/01

Sigma-Aldrich

Product number: 310500
Product name: N,N-Dimethylsphingosine
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 62575
Product name: N,N-Dimethylsphingosine
Purity: ≥98%
Packaging: 5mg
Price: $70
Updated: 2024/03/01

Cayman Chemical

Product number: 62575
Product name: N,N-Dimethylsphingosine
Purity: ≥98%
Packaging: 10mg
Price: $131
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0311
Product name: N,N-Dimethylsphingosine
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $442
Updated: 2024/03/01

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D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- Chemical Properties,Usage,Production

Description

N,N-Dimethylsphingosine (119567-63-4) is a synthetic derivative of D-erythro-sphingosine (Cat.# 10-2287). Endogenous sphingolipid.1?Inhibits sphingosine kinase (IC50 = 5 μM).2?N,N-Dimethylsphingosine induces apoptosis in a variety of cell lines.3

Chemical Properties

Colourless to Light Yellow Oil

Uses

D-erythro-N,N-Dimethylsphingosine is general modulator of protein kinases . D-erythro-N,N-Dimethylsphingosine is implicated in neuropathic pain.

Uses

N,N-Dimethylsphingosine is an inhibitor of sphingosine kinase (SPHK). It is a natural metabolite of sphingosine in some cancer cell lines and tissues. N,N-Dimethylsphingosine inhibited U937 cell SPHK with a Ki value of 3.1 μM. N,N-Dimethylsphingosine induces apoptosis, but it is not an inhibitor of protein kinase C.

Uses

A general modulator of protein kinases.

Definition

ChEBI: N,N-dimethylsphingosine is a sphingoid that is sphingosine in which the two amino hydrogens are replaced by methyl groups. It has a role as a metabolite and an EC 2.7.1.91 (sphingosine kinase) inhibitor. It is an aminodiol, a sphingoid and a tertiary amino compound. It is functionally related to a sphingosine. It is a conjugate base of a N,N-dimethylsphingosine(1+).

General Description

Dimethyl Sphingosine (d18:1), also called as N,N-Dimethyl-d-erythro-sphingosine (DMS), is a natural sphingolipid metabolite. It is found in various tissues.

Biochem/physiol Actions

N,N-Dimethylsphingosine (DMS) is an endogenous metabolite of sphingosine produced in various tissues and tumor cell lines. N,N-Dimethylsphingosine is a potent inhbitor of sphingosine kinase. DMS levels are elevated in the spinal cord, and contributes to allodynia, in a transected-nerve model of neuropathic pain.

References

1) Igarashi et al. (1990), A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells; J. Biol. Chem., 265 5385 2) Yatomi et al. (1996), N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets; Biochemistry, 35 626 3) Gude et al. (2008), Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal; FASEB J., 22 2629

D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- Preparation Products And Raw materials

Raw materials

Preparation Products

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D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- Suppliers

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View Lastest Price from D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- 119567-63-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

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