Isosorbide dimethyl ether
- Product Name
- Isosorbide dimethyl ether
- CAS No.
- 5306-85-4
- Chemical Name
- Isosorbide dimethyl ether
- Synonyms
- DIMETHYL ISOSORBIDE;DIMETHYL ISOBORBIDE;(3R,3aR,6S,6aR);2,5-dimethylisosorbide;O,O-DIMETHYLISOSORBIDE;DiMethyl Isosorbide(DMI);SOSORBIDE DIMETHYL ETHER;ISOSORBIDE DIMETHYL ETHER;lsosorbide dimethyl ether;IsosorbideDimethylEther>
- CBNumber
- CB0457121
- Molecular Formula
- C8H14O4
- Formula Weight
- 174.2
- MOL File
- 5306-85-4.mol
Isosorbide dimethyl ether Property
- Melting point:
- -70°C
- Boiling point:
- 93-95 °C0.1 mm Hg(lit.)
- Density
- 1.15 g/mL at 25 °C(lit.)
- vapor pressure
- 12.54Pa at 20℃
- refractive index
- n20/D 1.461(lit.)
- Flash point:
- 227 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- Liquid
- color
- Clear colorless to light yellow
- PH
- 7.0-8.0 (100g/l, H2O, 20℃)
- optical activity
- [α]21/D +96.1°, c = 2 in chloroform
- Water Solubility
- Soluble in water.
- BRN
- 80854
- InChIKey
- MEJYDZQQVZJMPP-ULAWRXDQSA-N
- LogP
- -1.62
- CAS DataBase Reference
- 5306-85-4(CAS DataBase Reference)
Safety
- Safety Statements
- 23-24/25
- WGK Germany
- 3
- HS Code
- 29092000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 906832
- Product name
- Dimethyl isosorbide
- Purity
- BioRenewable, ReagentPlus?, ≥99%
- Packaging
- 100ML
- Price
- $114
- Updated
- 2025/07/31
- Product number
- 906832
- Product name
- Dimethyl isosorbide
- Purity
- BioRenewable, ReagentPlus?, ≥99%
- Packaging
- 1L
- Price
- $164
- Updated
- 2025/07/31
- Product number
- 906832
- Product name
- Dimethyl isosorbide
- Purity
- BioRenewable, ReagentPlus?, ≥99%
- Packaging
- 2.5L
- Price
- $407
- Updated
- 2025/07/31
- Product number
- 906832
- Product name
- Dimethyl isosorbide
- Purity
- BioRenewable, ReagentPlus?, ≥99%
- Packaging
- 4L
- Price
- $567
- Updated
- 2025/07/31
- Product number
- 247898
- Product name
- Isosorbide dimethyl ether
- Purity
- 98%
- Packaging
- 25g
- Price
- $70.3
- Updated
- 2025/07/31
Isosorbide dimethyl ether Chemical Properties,Usage,Production
Chemical Properties
clear colorless to light yellow liquid. very stable under neutral conditions, hygroscopic and miscible with most organic solvents.
Uses
dimethyl isosorbide is a carrier, solvent, and viscosity controller. Its particular skin-penetrating ability opens the possibility of enhancing active substance efficacy in optical products. Its physical characteristics and solubility properties are superior to those of propylene glycol, glycerin, or ethyl alcohol.
Uses
Isosorbide dimethyl ether (DMI), a sustainable solvent, is widely used in various cosmetic and pharmaceutical formulations.
General applications:
DMI can be used as an alternative green solvent for epoxidation of cyclooctene, Baylis–Hillman reaction of isomaltulose-derived aldehydes with α,β-unsaturated ketones and also in solid-phase synthesis.
It can be used as a coalescent for water-borne paints, where it acts as a co-solvent during the water loss phase and as a coalescing agent during the film formation.
Preparation
Isosorbide dimethyl ether is synthesized from isosorbide by methylation.
Isosorbide dimethyl ether is obtained from stock like D-sorbitol, which is mainly derived from the hydrogenation of D-glucose.
Isosorbide dimethyl has a low level of toxicity and is referred to as a green solvent due to its production from renewable/raw material.
The boiling point of this solvent is high.
lt is used as a substitute to dimethyl sulfoxide,and dimethylformamide-like solvents.
General Description
Dimethyl isosorbide (DMI) is a biobased greener solvent and thus aligns with "Use of Renewable Feedstocks" and "Safer Solvents and Auxiliaries".
Flammability and Explosibility
Non flammable
Synthesis
110-71-4
652-67-5
162426-86-0
6941-54-4
5306-85-4
The general procedure for the synthesis of (3S,3aR,6R,6aR)-6-methoxyhexahydrofuro[3,2-b]furan-3-ol, (3R,3aR,6S,6aR)-6-methoxyhexahydrofuro[3,2-b]furan-3-ol, and isosorbide dimethylether using ethylene glycol dimethyl ether and isosorbide as raw materials is as follows: isosorbide, 1,2-dimethoxyethane ( ethylene glycol dimethyl ether) and heteropolyacid were sequentially added into a stainless steel high-pressure reactor and the reactor was sealed. The reaction mixture was magnetically stirred at 150°C for 5 hours. The molar ratio of 1,2-dimethoxyethane to isosorbide was 20:1, and the mass ratio of heteropolyacid to isosorbide was 0.2:1. After the reaction was completed, the reactor was cooled to room temperature. The reaction mixture was analyzed using gas chromatography, and the conversion and yield of the methylated product of isosorbide was calculated as molar percentage (mol%) by internal standard method.
References
[1] Patent: CN105646514, 2016, A. Location in patent: Paragraph 0041; 0042; 0043; 0044; 0045; 0046
[2] RSC Advances, 2015, vol. 5, # 31, p. 24139 - 24143
Isosorbide dimethyl ether Preparation Products And Raw materials
Raw materials
Preparation Products
Isosorbide dimethyl ether Suppliers
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View Lastest Price from Isosorbide dimethyl ether manufacturers
- Product
- 1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol 5306-85-4
- Price
- US $2.00-5.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons
- Release date
- 2025-07-10
- Product
- DIMETHYL ISOSORBIDE 5306-85-4
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100
- Release date
- 2024-10-30
- Product
- Dimethyl isosorbide 5306-85-4
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg/Month
- Release date
- 2024-04-28