Clopamide

ChemicalBook > CAS DataBase List > Clopamide

Product Name: Clopamide
CAS No.: 636-54-4
Chemical Name: Clopamide
Synonyms: Aquex;DT-327;Adurix;CLOPAMIDE;Brinaldix;CLOPAMIDUM;Clopamide CRS;ChlosudiMepriMyl;Clopamide (10mM in DMSO);N-(cis-2',6'-DiMethyl-1'-pip
CBNumber: CB0469173
Molecular Formula: C14H20ClN3O3S
Formula Weight: 345.84
MOL File: 636-54-4.mol

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Clopamide Property

Melting point:: 248-249℃
Density: 1.39±0.1 g/cm3(Predicted)
RTECS: CV2338875
storage temp.: 2-8°C
solubility: Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly)
pka: 9.41±0.60(Predicted)
form: Solid
color: Pale Yellow to Light Yellow
CAS DataBase Reference: 636-54-4(CAS DataBase Reference)
EPA Substance Registry System: Benzamide, 3-(aminosulfonyl)-4-chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]-, rel- (636-54-4)

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Safety

Hazard Codes: Xn
Risk Statements: 42/43
Safety Statements: 36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000848
Product name: Clopamide for system suitability
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000848
Price: $161
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0000833
Product name: Clopamide
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000833
Price: $153
Updated: 2024/03/01

Alfa Aesar

Product number: J67183
Product name: Clopamide, 98%
Packaging: 500mg
Price: $55.1
Updated: 2021/12/16

Cayman Chemical

Product number: 19356
Product name: Clopamide
Purity: ≥98%
Packaging: 500mg
Price: $46
Updated: 2024/03/01

TRC

Product number: C587160
Product name: Clopamide
Packaging: 10mg
Price: $180
Updated: 2021/12/16

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Clopamide Chemical Properties,Usage,Production

Chemical Properties

White or almost white, hygroscopic, crystalline powder

Originator

Brinaldix,Novartis

Uses

Antihypertensive; diuretic.

Uses

Antihypertensor;Gonad stimuling agent

Uses

Clopamide is a thiazide-like diuretic that inhibits sodium/chloride cotransporters in the proximal convoluted tubule of the kidney, which prevents the reabsorption of sodium and chloride. This compound is intended for research purposes only.

Definition

ChEBI: 4-chloro-N-[(2S,6R)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide is a sulfonamide.

Manufacturing Process

To a solution of 5.5 g of 3-chlorsulfonyl-4-chlorobenzoylchloride in 20 ml chlorobenzole 3.3 g of 1-amino-cis-2,6-dimethylpiperidin-hydrochloride slowly was added at room temperature. Reaction mixture was heated to 100°-105°C during 8 h, then it was cooled to room temperature. The precipitated crystals of N-[cis-2,6-dimethyl-piperidyl-(1)]-3-chlorsulfonyl-4-chlorobenzoylamide were filtered and dried at 100°C under vacuo, then was treated by ammonium at room temperature. The obtained product was chromatographed (aluminum oxide; eluent: chloroform-methanol 9:1 and methanol-ether) to give N-[cis- 2,6-dimethylpiperidyl-(1)]-3-sulfamyl-4-chlorbenzoylamide, melting point 235°-237°C.

brand name

Aquex (Novartis).

Therapeutic Function

Diuretic, Antihypertensive

Clopamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Clopamide manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Clopamide 636-54-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

636-54-4, ClopamideRelated Search:

N,N-Dimethyl-1,4-phenylenediamine Pamidronate disodium salt p-Aminobenzamide Chlorantraniliprole Chloroacetamide Cloperastine hydrochloride Loperamide hydrochloride Polyacrylamide Disodium pamidronate Trazodone Benzamide Difluorochloromethane PamidronicAcid cis-2,6-Dimethylpiperidine 2,6-Dimethylpiperidine Clopamide for system suitability Clopamide 4-t-Butylbenzamide

4-CHLORO-N-[2,6-DIMETHYLPIPERIDINYL]-3-SULFAMOYLBENZAMIDE

4-chloro-N-(2,6-dimethylpiperidino)-3-sulphamoylbenzamide

CLOPAMIDE

4-Chloro-N-[(2R,6S)-2,6-dimethylpiperidino)-3-sulfamoylbenzamide

Adurix

Aquex

Brinaldix

DT-327

CLOPAMIDUM

4-Chloro-N-(cis-2,6-dimethylpiperidino)-3-sulfamoylbenzamide

ChlosudiMepriMyl

N-(cis-2',6'-DiMethyl-1'-pip

rel-3-(AMinosulfonyl)-4-chloro-N-[(2R,6S)-2,6-diMethyl-1-piperidinyl]benzaMide

4-Chloro-N-[2,6-dimethylpiperidino]-3-sulfamolybenzamide

Clopamide CRS

Clopamide for system suitability CRS

Benzamide, 3-(aminosulfonyl)-4-chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]-, rel-

4-Chloro-N-[(2RS,6SR)-2,6-dimethylpiperidin-1-yl]-3-sulfamoylbenzamide

Clopamide (10mM in DMSO)

ClopamideQ: What is Clopamide Q: What is the CAS Number of Clopamide Q: What is the storage condition of Clopamide Q: What are the applications of Clopamide

636-54-4

C14H20ClN3O3S

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