Clopamide Property

Melting point:

248-249℃

Density 

1.39±0.1 g/cm3(Predicted)

RTECS 

CV2338875

storage temp. 

2-8°C

solubility 

Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly)

pka

9.41±0.60(Predicted)

form 

Solid

color 

Pale Yellow to Light Yellow

CAS DataBase Reference

636-54-4(CAS DataBase Reference)

EPA Substance Registry System

Benzamide, 3-(aminosulfonyl)-4-chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]-, rel- (636-54-4)

Safety

Hazard Codes 

Xn

Risk Statements 

42/43

Safety Statements 

36

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

Clopamide Chemical Properties,Usage,Production

Chemical Properties

White or almost white, hygroscopic, crystalline powder

Originator

Brinaldix,Novartis

Uses

Antihypertensive; diuretic.

Uses

Antihypertensor;Gonad stimuling agent

Uses

Clopamide is a thiazide-like diuretic that inhibits sodium/chloride cotransporters in the proximal convoluted tubule of the kidney, which prevents the reabsorption of sodium and chloride. This compound is intended for research purposes only.

Definition

ChEBI: 4-chloro-N-[(2S,6R)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide is a sulfonamide.

Manufacturing Process

To a solution of 5.5 g of 3-chlorsulfonyl-4-chlorobenzoylchloride in 20 ml chlorobenzole 3.3 g of 1-amino-cis-2,6-dimethylpiperidin-hydrochloride slowly was added at room temperature. Reaction mixture was heated to 100°-105°C during 8 h, then it was cooled to room temperature. The precipitated crystals of N-[cis-2,6-dimethyl-piperidyl-(1)]-3-chlorsulfonyl-4-chlorobenzoylamide were filtered and dried at 100°C under vacuo, then was treated by ammonium at room temperature. The obtained product was chromatographed (aluminum oxide; eluent: chloroform-methanol 9:1 and methanol-ether) to give N-[cis- 2,6-dimethylpiperidyl-(1)]-3-sulfamyl-4-chlorbenzoylamide, melting point 235°-237°C.

brand name

Aquex (Novartis).

Therapeutic Function

Diuretic, Antihypertensive