LIAROZOLE DIHYDROCHLORIDE

Product Name: LIAROZOLE DIHYDROCHLORIDE
CAS No.: 1883548-96-6
Chemical Name: LIAROZOLE DIHYDROCHLORIDE
Synonyms: R75251 dihydrochloride;LIAROZOLE DIHYDROCHLORIDE;Liarozole dihydrochloride >=98% (HPLC)
CBNumber: CB04740469
Molecular Formula: C17H14Cl2N4
Formula Weight: 345.23
MOL File: 1883548-96-6.mol

More

Less

LIAROZOLE DIHYDROCHLORIDE Property

storage temp.: room temp
solubility: Water: ≥ 50 mg/mL (131.00 mM); DMSO: 50 mg/mL (131.00 mM)
form: powder
color: white to beige
Water Solubility: H2O: 2mg/mL, clear

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Tocris

Product number: 2705
Product name: Liarozole dihydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $205
Updated: 2021/12/16

ChemScene

Product number: CS-0033188
Product name: Liarozole dihydrochloride
Purity: ≥99.0%
Packaging: 5mg
Price: $280
Updated: 2021/12/16

More

Less

LIAROZOLE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Biological Activity

Liarozole (R 75251, R75,251) is an orally active benzimidazole-based retinoic acid (RA) metabolism blocking agent (RAMBA) th at targets multiple P450 enzymes, including aromatase (CYP19), 17-hydroxylase/17,20-lyase (CYP17A1), 11-hydroxylase (CYP11B1), and RA 4-hydroxylase (CYP26). Liarozole is more effective than ketoconazole in vivo (plasma RA enhancement = 2.5 ng/mL vs. 1.3 ng/mL 2 hr after respective oral dosage of 40 mg/kg in rats) and, in contrast to ketoconazole, Liarozole does not significantly affect circulating adrenal androgen levels. Liarozole is shown to effectively suppress androgen-dependent tumor expansion of R3327G Dunning prostate adenocarcinoma xenografts in rats (by 66% and 81% with 80 and 120 mg/kg/day p.o., respectively) independent of its androgen biosynthesis inhibition.

storage

Desiccate at RT

LIAROZOLE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

LIAROZOLE DIHYDROCHLORIDE Suppliers

China 14 Japan 1 United States 4 USA 1 Global 20

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 5960
Advantage: 55

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988968278
Fax: QQ：3283937693
Email: sales@ubiochem.com
Country: China
ProdList: 4297
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44807
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Shanghai Tachizaki Biomedical Research Center

Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Country: China
ProdList: 2619
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9266
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 028-81700200 13308200041
Email: 2851167782@qq.com
Country: China
ProdList: 11183
Advantage: 58

R&D Systems, Inc

Tel: 18003437475
Email: rdname@qq.com
Country: CHINA
ProdList: 35705
Advantage: 58

Guangzhou Weijia Technology Co., Ltd.

Tel: --
Fax: --
Email: WHIGA22@126.COM
Country: CHINA
ProdList: 6748
Advantage: 58

Beijing Bolide Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1985563437@qq.com
Country: CHINA
ProdList: 6158
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

1883548-96-6, LIAROZOLE DIHYDROCHLORIDERelated Search:

LIAROZOLE DIHYDROCHLORIDE

R75251 dihydrochloride

Liarozole dihydrochloride >=98% (HPLC)

1883548-96-6